Search Results - "Whitley, Guy S."

Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces by James, Joanna L, Whitley, Guy S, Cartwright, Judith E

“…The success of pregnancy is a result of countless ongoing interactions between the placenta and the maternal immune and cardiovascular systems. Pre-eclampsia…”
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Biomarkers in Painful Symptomatic Knee OA Demonstrate That MRI Assessed Joint Damage and Type II Collagen Degradation Products Are Linked to Disease Progression by Sofat, Nidhi, Ejindu, Vivian, Heron, Christine, Harrison, Abiola, Koushesh, Soraya, Assi, Lena, Kuttapitiya, Anasuya, Whitley, Guy S, Howe, Franklyn A

“…Osteoarthritis (OA) is the most prevalent arthritis worldwide, but the evolution of pain in relation to joint damage and biochemical markers are not well…”
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Stanniocalcin-1 in the female reproductive system and pregnancy by Bishop, Alexa, Cartwright, Judith E, Whitley, Guy S

“…Abstract BACKGROUND Stanniocalcin-1 (STC-1) is a widely expressed glycoprotein hormone involved in a diverse spectrum of physiological and pathophysiological…”
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Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice by Vasilopoulou, Elisavet, Loubière, Laurence S, Heuer, Heike, Trajkovic-Arsic, Marija, Darras, Veerle M, Visser, Theo J, Lash, Gendie E, Whitley, Guy S, McCabe, Christopher J, Franklyn, Jayne A, Kilby, Mark D, Chan, Shiao Y

“…Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH…”
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Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre‐eclampsia by Wallace, Alison E., Whitley, Guy S., Thilaganathan, Baskaran, Cartwright, Judith E.

“…HLA‐interacting cell surface receptors are altered on decidual natural killer cells in pregnancy, potentially altering interactions with fetal cells via…”
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Decidual Natural Killer Cell Interactions with Trophoblasts Are Impaired in Pregnancies at Increased Risk of Preeclampsia by Wallace, Alison E, Host, Amanda J, Whitley, Guy S, Cartwright, Judith E

“…Transformation of the uterine spiral arteries (SAs) during pregnancy is critical to support the developing fetus, and is impaired in some pregnancy disorders,…”
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Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia by Nonn, Olivia, Fischer, Cornelius, Geisberger, Sabrina, El-Heliebi, Amin, Kroneis, Thomas, Forstner, Désirée, Desoye, Gernot, Staff, Anne Cathrine, Sugulle, Meryam, Dechend, Ralf, Pecks, Ulrich, Kollmann, Martina, Stern, Christina, Cartwright, Judith E., Whitley, Guy S., Thilaganathan, Basky, Wadsack, Christian, Huppertz, Berthold, Herse, Florian, Gauster, Martin

“…Various studies found an association of different renin-angiotensin system (RAS) components with gestational duration and preterm birth, as well as with…”
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Regulation of stanniocalcin‐1 secretion by BeWo cells and first trimester human placental tissue from normal pregnancies and those at increased risk of developing preeclampsia by Abid, Naila, Embola, Joan, Tryfonos, Zoe, Bercher, Julia, Ashton, Sandra V., Khalil, Asma, Thilaganathan, Baskaran, Cartwright, Judith E., Whitley, Guy S.

“…Stanniocalcin‐1 (STC‐1) is a multi‐functional glycosylated peptide present in the plasma of healthy women postpartum and increased further in pregnancies…”
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Investigating the role of tumour cell derived iNOS on tumour growth and vasculature in vivo using a tetracycline regulated expression system by Papaevangelou, Efthymia, Whitley, Guy S., Johnstone, Alan P., Robinson, Simon P., Howe, Franklyn A.

“…Nitric oxide (NO) is a free radical signalling molecule involved in various physiological and pathological processes, including cancer. Both tumouricidal and…”
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The phenotype of decidual CD56+ lymphocytes is influenced by secreted factors from decidual stromal cells but not macrophages in the first trimester of pregnancy by James-Allan, Laura B., Buckley, Rebecca J., Whitley, Guy S., Cartwright, Judith E.

“…•The unique phenotype of dNK cells results from the decidual environment.•DSC secreted factors stimulate the secretion of cytokines IL-6 and IL-8 from first…”
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First trimester placental endothelial cells from pregnancies with abnormal uterine artery Doppler are more sensitive to apoptotic stimuli by Charolidi, Nicoletta, Host, Amanda J., Ashton, Sandra, Tryfonos, Zoe, Leslie, Karin, Thilaganathan, Baskaran, Cartwright, Judith E., Whitley, Guy S.

“…Failure of the placental capillary network to develop normally is associated with early onset fetal growth restriction (FGR) and pre-eclampsia (PE). Although…”
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Trophoblast-Induced Changes in C-X-C Motif Chemokine 10 Expression Contribute to Vascular Smooth Muscle Cell Dedifferentiation During Spiral Artery Remodeling by Wallace, Alison E, Cartwright, Judith E, Begum, Runa, Laing, Ken, Thilaganathan, Baskaran, Whitley, Guy S

“…OBJECTIVE—During pregnancy, fetal trophoblast disrupt endothelial cell and vascular smooth muscle cell (VSMC) interactions in spiral arteries of the maternal…”
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Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo by Papaevangelou, Efthymia, Boult, Jessica K. R., Whitley, Guy S., Robinson, Simon P., Howe, Franklyn A.

“…Nitric oxide (NO) has been strongly implicated in glioma progression and angiogenesis. The endogenous inhibitors of NO synthesis, asymmetric dimethylarginine…”
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Shear stress and spiral artery remodelling: the effects of low shear stress on trophoblast-induced endothelial cell apoptosis by JAMES, Joanna L, WHITLEY, Guy S, CARTWRIGHT, Judith E

“…In the first trimester of pregnancy, placental trophoblasts migrate along uterine spiral arteries (SA) and replace endothelial cells (EC) lining these vessels…”
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Oxygen modulates human decidual natural killer cell surface receptor expression and interactions with trophoblasts by Wallace, Alison E, Goulwara, Sonu S, Whitley, Guy S, Cartwright, Judith E

“…Decidual natural killer (dNK) cells have been shown to both promote and inhibit trophoblast behavior important for decidual remodeling in pregnancy and have a…”
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The regulation of trophoblast migration across endothelial cells by low shear stress: consequences for vascular remodelling in pregnancy by James, Joanna L., Cartwright, Judith E., Whitley, Guy S., Greenhill, Darrel R., Hoppe, Andreas

“…Aims In early human pregnancy placental trophoblasts migrate along uterine spiral arteries (SAs) and remodel these vessels into wide-bore conduits in a process…”
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Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction by Gunatillake, Tilini, Yong, Hannah E J, Dunk, Caroline E, Keogh, Rosemary J, Borg, Anthony J, Cartwright, Judith E, Whitley, Guy S, Murthi, Padma

“…Aberrant placental angiogenesis is associated with fetal growth restriction (FGR). In mice, targeted disruption of the homeobox gene, transforming growth…”
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Oxygen Modulates Human Decidual Natural Killer Cell Surface Receptor Expression and Interactions with Trophoblasts1 by Wallace, Alison E, Goulwara, Sonu S, Whitley, Guy S, Cartwright, Judith E

“…Decidual natural killer (dNK) cells have been shown to both promote and inhibit trophoblast behavior important for decidual remodeling in pregnancy and have a…”
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Caffeine Inhibits EGF-Stimulated Trophoblast Cell Motility through the Inhibition of mTORC2 and Akt by Grant, Isobelle, Cartwright, Judith E, Lumicisi, Brooke, Wallace, Alison E, Whitley, Guy S

“…Impaired trophoblast invasion is associated with pregnancy disorders such as early pregnancy loss and preeclampsia. There is evidence to suggest that the…”
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Abstract 422: DUSP2 Dysregulation By TSP1-CD47 Signaling May Contribute To Maladaptive Aortic Remodeling In Hypertension And Hypertensive Heart Disease Progression by Haines, Zoe H, Sun, Patrick, Whitley, Guy S, Meijles, Daniel, Khomtchouk, Bohdan B

“…Abstract only Hypertensive remodeling involves upregulation of fibrotic players, such as the thrombospondin-1 (TSP1). TSP1, via CD47, is anti-angiogenic;…”
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