Search Results - "Whitley, G S"

The in Vitro Effects of Triiodothyronine on Epidermal Growth Factor-Induced Trophoblast Function by Barber, K. J., Franklyn, J. A., McCabe, C. J., Khanim, F. L., Bulmer, J. N., Whitley, G. S. J., Kilby, M. D.

“…The development of the human placenta involves a complex process of tightly regulated proliferation and invasion by extravillous trophoblast into the uterine…”
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Expression of voltage-dependent potassium channels in first trimester human placentae by Mistry, H.D, Kurlak, L.O, Whitley, G.S, Cartwright, J.E, Broughton Pipkin, F, Tribe, R.M

“…Abstract Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV 7), modulated by KCNE1-5 encoded accessory proteins. The aim…”
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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase by MacAllister, Raymond J., Parry, Heather, Kimoto, Masumi, Ogawa, Tadashi, Russell, Rachel J., Hodson, Harold, Whitley, Guy St.J., Vallance, Patrick

“…1 Dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes the endogenous nitric oxide synthase inhibitors NG‐monomethyl‐L‐arginine and NG,…”
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BeWo cells stimulate smooth muscle cell apoptosis and elastin breakdown in a model of spiral artery transformation by Harris, L.K., Keogh, R.J., Wareing, M., Baker, P.N., Cartwright, J.E., Whitley, G.S., Aplin, J.D.

“…BACKGROUND During pregnancy, extravillous trophoblast invades the uterine wall and enters the spiral arteries. Remodelling ensues, with loss of vascular smooth…”
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First‐trimester uterine artery resistance and maternal serum concentration of asymmetric dimethylarginine by Prefumo, F., Thilaganathan, B., Whitley, G. S.

“…Objective Maternal serum levels of asymmetric dimethyl‐ arginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase, are known to be…”
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Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia by Holden, Desmond P., Fickling, Sara A., Whitley, Guy St.J., Nussey, Stephen S.

“…OBJECTIVE: We investigated the change in the plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in early-,…”
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Decidual cell regulation of trophoblast is altered in pregnancies at risk of pre-eclampsia by James-Allan, L B, Whitley, G S, Leslie, K, Wallace, A E, Cartwright, J E

“…Successful implantation and placentation are dependent on the interaction between decidual stromal cells (DSC) and extravillous trophoblast (EVT) cells. The…”
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Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function by Wallace, A.E., Fraser, R., Gurung, S., Goulwara, S.S., Whitley, G.S., Johnstone, A.P., Cartwright, J.E.

“…STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery…”
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Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide by Cartwright, Judith E, Holden, Desmond P, Whitley, Guy St J

“…The expression of hepatocyte growth factor (HGF) is essential for normal placental development although its function is unknown. In this study we examined the…”
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Macrophage polarisation affects their regulation of trophoblast behaviour by Buckley, R.J, Whitley, G.S, Dumitriu, I.E, Cartwright, J.E

“…Abstract Introduction During the first trimester of human pregnancy, fetally-derived extravillous trophoblast (EVT) cells invade into uterine decidua and…”
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Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis by MacAllister, Raymond J., Fickling, Sara A., Whitley, Guy St. J., Vallance, Patrick

“…1 The metabolism of methylarginines by human cultured endothelial cells and human saphenous vein was studied in vitro. The human endothelial cell line…”
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Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL by Lumicisi, B.A., Cartwright, J.E., Leslie, K., Wallace, A.E., Whitley, G.S.

“…STUDY QUESTION Does inhibition of dimethylarginine dimethylaminohydrolase (DDAH) increase the sensitivity of trophoblasts to TRAIL-induced apoptosis? SUMMARY…”
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Endogenously produced nitric oxide inhibits endothelial cell growth as demonstrated using novel antisense cell lines by Cartwright, Judith E, Johnstone, Alan P, Whitley, Guy St J

“…Proliferation of endothelial cells is a vital component of vascular repair and angiogenesis. The endothelial cell mediator, nitric oxide (NO) has been reported…”
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The Effects of Angiogenic Growth Factors on Extravillous Trophoblast Invasion and Motility by Lash, G.E, Cartwright, J.E, Whitley, G.St J, Trew, A.J, Baker, P.N

“…There is accumulating evidence that deficient trophoblast invasion of the placental bed spiral arteries is crucial to the pathogenesis of pre-eclampsia and…”
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P41.03: Uterine artery Doppler at 10–14 weeks and maternal serum concentrations of asymmetric dimethylarginine by Prefumo, F., Whitley, G. S., Thilaganathan, B.

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Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine by HOLDEN, Desmond P, CARTWRIGHT, Judith E, NUSSEY, Stephen S, WHITLEY, Guy St J

“…Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial cells. This effect has been attributed to…”
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Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension by MILLATT, Lesley J, WHITLEY, Guy Stj, LI, Dechun, LEIPER, James M, SIRAGY, Helmy M, CAREY, Robert M, JOHNS, Roger A

“…Chronic hypoxia-induced pulmonary hypertension is associated with increased pulmonary expression of nitric oxide synthase (NOS) enzymes. Nevertheless, some…”
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Effect of anti‐fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase by Bogle, R.G., Whitley, G.St.J., Soo, S.‐C., Johnstone, A.P., Vallance, P.

“…1 Experiments were performed to examine the effects of anti‐fungal imidazole compounds (clotrimazole, econazole and miconazole) on the induction of nitric…”
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Effect of heparin and fractionated heparin on trophoblast invasion by Ganapathy, R., Whitley, G. St J., Cartwright, J.E., Dash, P.R., Thilaganathan, B.

“…BACKGROUND Heparin can significantly reduce pregnancy complications in women with certain thrombophilias, such as antiphospholipid syndrome. Recent reports…”
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Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP by MILLATT, L. J, JOHNSTONE, A. P, NUSSEY, S. S, WHITLEY, G. S

“…The thyroid gland produces and responds to the signalling molecule nitric oxide (NO). The activity of NO synthase (NOS) may be regulated by endogenous NOS…”
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