Search Results - "Whitham, R"

Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial by Lovera, JF, Frohman, E., Brown, TR, Bandari, D., Nguyen, L., Yadav, V., Stuve, O., Karman, J., Bogardus, K., Heimburger, G., Cua, L., Remingon, G., Fowler, J., Monahan, T., Kilcup, S., Courtney, Y., McAleenan, J., Butler, K., Wild, K., Whitham, R., Bourdette, D.

“…Background: Memantine, an NMDA antagonist, is effective for moderate to severe Alzheimer’s disease. Objective: Determine whether memantine improves cognitive…”
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American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study by Kim, E, Cameron, M, Lovera, J, Schaben, L, Bourdette, D, Whitham, R

“…This study examined the safety and efficacy of an escalating dose (100 mg, 200 mg, 400 mg/day) of American ginseng over 6 weeks in a single-center, randomized,…”
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Inappropriate measurement of postoperative c-reactive protein in trauma and orthopaedic surgery: A quality improvement project by Glasbey, J, Galloway, L, Whitham, R, Parker, S, Blocker, O, Ghandour, A

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Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial by Lovera, J., Bagert, B., Smoot, K., Morris, C.D., Frank, R., Bogardus, K., Wild, K., Oken, B., Whitham, R., Bourdette, D.

“…Objectives To determine if Ginkgo biloba (GB) improves the cognitive performance of subjects with multiple sclerosis (MS). Methods Randomized, double-blind,…”
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Enhanced recovery programmes for lower limb arthroplasty in the UK by Nagra, N S, Hamilton, T W, Strickland, L, Murray, D W, Pandit, H

“…Enhanced recovery programmes (ERPs) reduce patient morbidity and mortality, and provide significant cost savings by reducing length of stay. Currently, no…”
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Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis by RUDICK, R. A, GOODKIN, D. E, ALAM, J. J, SIMONIAN, N. A, CAMPION, M. K, BARTOSZAK, D. M, BOURDETTE, D. N, BRAIMAN, J, BROWNSCHEIDLE, C. M, COATS, M. E, COHAN, S. L, DOUGHERTY, D. S, JACOBS, L. D, KINKEL, R. P, MASS, M. K, MUNSCHAUER, F. E, PRIORE, R. L, PULLICINO, P. M, SCHEROKMAN, B. J, WEISTOCK-GUTTMAN, B, WHITHAM, R. H, COOKFAIR, D. L, HERNDON, R. M, RICHERT, J. R, SALAZAR, A. M, FISCHER, J. S, GRANGER, C. V, SIMON, J. H

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A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis by Bourdette, D N, Edmonds, E, Smith, C, Bowen, J D, Guttmann, C RG, Nagy, Z P, Simon, J, Whitham, R, Lovera, J, Yadav, V, Mass, M, Spencer, L, Culbertson, N, Bartholomew, R M, Theofan, G, Milano, J, Offner, H, Vandenbark, A A

“…Background: T cell receptor (TCR) peptide vaccination is a novel approach to treating multiple sclerosis (MS). The low immunogenicity of previous vaccines has…”
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Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis by Weinberg, Andrew D, Wegmann3, Keith W, Funatake, Castle, Whitham, Ruth H

“…The OX-40R is a member of the TNF receptor family and is expressed primarily on activated CD4+ T cells. When the OX-40R is engaged by the OX-40 ligand…”
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Expression of a functional antibody fragment in the gut of Rhodnius prolixus via transgenic bacterial symbiont Rhodococcus rhodnii by Durvasula, R.V, Gumbs, A, Panackal, A, Kruglov, O, Taneja, J, Kang, A.S, Cordon-Rosales, C, Richards, F.F, Whitham, R.G, Beard, C.B

“…Expression within insects of foreign antiparasitic gene products via microbial symbionts could be used to prevent transmission of vector-borne pathogens to…”
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Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis by WHITHAM, R. H, BOURDETTE, D. N, HASHIM, G. A, HERNDON, R. M, ILG, R. C, VANDENBARK, A. A, OFFNER, H

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) can be induced in SJL/J mice by immunization with spinal cord homogenate and adjuvant. The specific…”
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Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis: Multiple sclerosis by RUDICK, R. A, GOODKIN, D. E, ALAM, J. J, SIMONIAN, N. A, CAMPION, M. K, BARTOSZAK, D. M, BOURDETTE, D. N, BRAIMAN, J, BROWNSCHEIDLE, C. M, COATS, M. E, COHAN, S. L, DOUGHERTY, D. S, JACOBS, L. D, KINKEL, R. P, MASS, M. K, MUNSCHAUER, F. E, PRIORE, R. L, PULLICINO, P. M, SCHEROKMAN, B. J, WEISTOCK-GUTTMAN, B, WHITHAM, R. H, COOKFAIR, D. L, HERNDON, R. M, RICHERT, J. R, SALAZAR, A. M, FISCHER, J. S, GRANGER, C. V, SIMON, J. H

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Immunity to TCR peptides in multiple sclerosis. II: T cell recognition of Vβ5.2 and Vβ6.1 CDR2 peptides by CHOU, Y. K, MORRISON, W. J, WEINBERG, A. D, DEDRICK, R, WHITHAM, R, BOURDETTE, D. N, HASHIM, G, OFFNER, H, VANDENBARK, A. A

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Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice by Whitham, RH, Jones, RE, Hashim, GA, Hoy, CM, Wang, RY, Vandenbark, AA, Offner, H

“…Synthetic peptides of proteolipid protein (PLP) were screened for their ability to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J, PL/J, and…”
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Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study by Panitch, Hillel, Miller, Aaron, Paty, Donald, Weinshenker, Brian

“…To evaluate the efficacy and safety of interferon beta-1b (IFNbeta-1b) in subjects with secondary progressive multiple sclerosis (SPMS). This 3-year,…”
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Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides by Whitham, R H, Kotzin, B L, Buenafe, A C, Weinberg, A D, Jones, R E, Hashim, G A, Hoy, C M, Vandenbark, A A, Offner, H

“…Restricted T cell receptor (TCR) VB gene usage by T cells for recognition of antigens involved in the production of experimental autoimmune encephalomyelitis…”
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The Effects of Dalfampridine on Walking Speed, Endurance, and Community Participation in a Veteran Population: A Retrospective Cohort Study (P04.123) by Overs, S., Fitzpatrick, M., Dryden, J., Whitham, R., Cameron, M.

“…Abstract only…”
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Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells by Jones, RE, Bourdette, DN, Whitham, RH, Offner, H, Vandenbark, AA

“…Severe combined immunodeficient (SCID) C.B-17-scid/scid (H-2d) strain mice are deficient for T and B lymphocytes and lack all of the immune functions…”
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Response of human T lymphocyte lines to myelin basic protein: association of dominant epitopes with HLA class II restriction molecules by Chou, Y K, Vainiene, M, Whitham, R, Bourdette, D, Chou, C H, Hashim, G, Offner, H, Vandenbark, A A

“…In animals, the selection in vitro of T cell lines to myelin basic protein (MBP) can define immunodominant and encephalitogenic epitopes which are…”
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MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR Vβ CDR2 peptides: Comparison with myelin basic protein-specific T cells by Chou, Y.K., Weinberg, A.D., Buenafe, A., Bourdette, D.N., Whitham, R., Kaleeba, J.A.R., Robey, I.F., Kavanagh, D.G., Offner, H., Vandenbark, A.A.

“…HLA‐DR2+ patients with multiple sclerosis (MS) that respond to vaccination with TCR Vβ5.2‐38‐58 peptides have increased frequencies of TCR peptide‐specific T…”
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Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein by Chou, Y K, Henderikx, P, Vainiene, M, Whitham, R, Bourdette, D, Chou, C H, Hashim, G, Offner, H, Vandenbark, A A

“…Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify…”
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