Communication skills in children aged 6–8 years, without cerebral palsy cooled for neonatal hypoxic-ischemic encephalopathy

We assessed communication skills of 48 children without cerebral palsy (CP) treated with therapeutic hypothermia (TH) for neonatal hypoxic-ischemic encephalopathy (HIE) (cases) compared to 42 controls at early school-age and examined their association with white matter diffusion properties in both g...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; pp. 17757 - 10
Main Authors:	Robb, Thomas J., Tonks, James, Spencer, Arthur P. C., Jary, Sally, Whitfield, Charlotte K., Thoresen, Marianne, Cowan, Frances M., Chakkarapani, Ela
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22-10-2022 Nature Publishing Group Nature Portfolio
Subjects:	631/378/2649/1594 692/308/3187 692/617/375/1345/3190 692/617/375/2764/3195 692/617/375/3183 Anisotropy Autism Brain Brain damage Cerebral palsy Cerebral Palsy - therapy Child Children Cingulum Communication Corpus callosum Diffusion Tensor Imaging Encephalopathy Humanities and Social Sciences Humans Hypothermia Hypoxia Hypoxia-Ischemia, Brain - therapy Infant, Newborn Ischemia Language multidisciplinary Neonates Paralysis Science Science (multidisciplinary) Substantia alba White Matter - diagnostic imaging
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Summary:	We assessed communication skills of 48 children without cerebral palsy (CP) treated with therapeutic hypothermia (TH) for neonatal hypoxic-ischemic encephalopathy (HIE) (cases) compared to 42 controls at early school-age and examined their association with white matter diffusion properties in both groups and 18-month Bayley-III developmental assessments in cases. Parents completed a Children’s Communication Checklist (CCC-2) yielding a General Communication Composite (GCC), structural and pragmatic language scores and autistic-type behavior score. GCC ≤ 54 and thresholds of structural and pragmatic language score differences defined language impairment. Using tract-based spatial statistics (TBSS), fractional anisotropy (FA) was compared between 31 cases and 35 controls. Compared to controls, cases had lower GCC ( p = 0.02), structural ( p = 0.03) and pragmatic language score ( p = 0.04) and higher language impairments ( p = 0.03). GCC correlated with FA in the mid-body of the corpus callosum, the cingulum and the superior longitudinal fasciculus ( p < 0.05) in cases. Bayley-III Language Composite correlated with GCC (r = 0.34, p = 0.017), structural (r = 0.34, p = 0.02) and pragmatic (r = 0.32, p = 0.03) language scores and autistic-type behaviors (r = 0.36, p = 0.01).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-21723-1