Search Results - "Whiteside, T. L"

The tumor microenvironment and its role in promoting tumor growth by Whiteside, T L

“…The tumor microenvironment is created by the tumor and dominated by tumor-induced interactions. Although various immune effector cells are recruited to the…”
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Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients by Jie, H-B, Gildener-Leapman, N, Li, J, Srivastava, R M, Gibson, S P, Whiteside, T L, Ferris, R L

“…Background: Although regulatory T cells (Treg) are highly enriched in human tumours compared with peripheral blood, expression of the immune-checkpoint…”
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The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg) by Whiteside, T L, Mandapathil, M, Schuler, P

“…Tumor-induced dysfunction of immune cells is a common problem in cancer. Tumors induce immune suppression by many different mechanisms, including accumulation…”
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TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer by Szajnik, M, Szczepanski, M J, Czystowska, M, Elishaev, E, Mandapathil, M, Nowak-Markwitz, E, Spaczynski, M, Whiteside, T L

“…Toll-like receptors (TLRs) expressed on immune cells trigger inflammatory responses. TLRs are also expressed on ovarian cancer (OvCa) cells, but the…”
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Exosomes carrying immunoinhibitory proteins and their role in cancer by Whiteside, T. L.

“…Summary Recent emergence of exosomes as information carriers between cells has introduced us to a new previously unknown biological communication system…”
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Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer by SCHAEFER, C, KIM, G. G, ALBERS, A, HOERMANN, K, MYERS, E. N, WHITESIDE, T. L

“…Patients with squamous cell carcinoma of the head and neck (SCCHN) have depressed antitumour immunity. The presence of CD4+CD25+ (Treg) cells in these patients…”
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The emerging roles of tumor-derived exosomes in hematological malignancies by Boyiadzis, M, Whiteside, T L

“…Exosomes are small (30–150 nm) membranous vesicles of endocytic origin produced by all cells under physiological and pathological conditions. They have…”
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Tumour-derived exosomes or microvesicles: another mechanism of tumour escape from the host immune system? by Whiteside, T L

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Separation of plasma‐derived exosomes into CD3(+) and CD3(–) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients by Theodoraki, M.‐N., Hoffmann, T. K., Whiteside, T. L.

“…Summary Head and neck squamous cell carcinoma (HNSCC) is a highly immunosuppressive malignancy. Exosomes in HNSCC patients' plasma are enriched in inhibitory…”
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IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death by Czystowska, M, Han, J, Szczepanski, M J, Szajnik, M, Quadrini, K, Brandwein, H, Hadden, J W, Signorelli, K, Whiteside, T L

“…IRX-2 is a cytokine-based biologic agent that has the potential to enhance antitumor immune responses. We investigated whether IRX-2 can protect T cells from…”
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IRX-2, a novel immunotherapeutic, enhances and protects NK-cell functions in cancer patients by Schilling, B., Halstead, E. S., Schuler, P., Harasymczuk, M., Egan, J. E., Whiteside, T. L.

“…Background IRX-2 is a primary biologic which has been used for the therapy of head and neck squamous cell cancer (HNSCC) with promising clinical results. Since…”
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Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence by Theodoraki, M.‐N., Hoffmann, T. K., Jackson, E. K., Whiteside, T. L.

“…Summary Exosomes in plasma of head and neck squamous cell carcinoma (HNSCC) patients comprise subsets of vesicles derived from various cells. Recently, we…”
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Prolactin receptor is a negative prognostic factor in patients with squamous cell carcinoma of the head and neck by Bauernhofer, T, Pichler, M, Wieckowski, E, Stanson, J, Aigelsreiter, A, Griesbacher, A, Groselj-Strele, A, Linecker, A, Samonigg, H, Langner, C, Whiteside, T L

“…Background: The influence of human prolactin (hPRL) on the development of breast and other types of cancer is well established. Little information, however,…”
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Inhibition of apoptosis in human tumour cells by the tumour-associated serpin, SCC antigen-1 by SUMINAMI, Y, NAGASHIMA, S, VUJANOVIC, N. L, HIRABAYASHI, K, KATO, H, WHITESIDE, T. L

“…The squamous cell carcinoma antigen (SCC Ag) is a tumour-associated protein and a member of the serine protease inhibitor (serpin) family. The SCC Ag has been…”
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Human CD4+CD39+ regulatory T cells produce adenosine upon co‐expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells by Schuler, P. J., Saze, Z., Hong, C.‐S., Muller, L., Gillespie, D. G., Cheng, D., Harasymczuk, M., Mandapathil, M., Lang, S., Jackson, E. K., Whiteside, T. L.

“…Summary While murine CD4+CD39+ regulatory T cells (Treg) co‐express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive…”
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Signaling defects in T lymphocytes of patients with malignancy by WHITESIDE, T. L

“…In patients with cancer, alterations in the expression of T-cell receptor-associated molecules in tumor-infiltrating lymphocytes (TIL) as well as in…”
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Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients by Theodoraki, M.-N., Laban, S., Jackson, E. K., Lotfi, R., Schuler, P. J., Brunner, C., Hoffmann, T. K., Whiteside, T. L., Hofmann, L.

“…Background Head and neck cancers (HNSCC) are highly immunosuppressive. Plasma-derived exosomes of HNSCC patients carry immunomodulatory molecules, and their…”
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Generation of tumor-specific T lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells by HOFFMANN, T. K, MEIDENBAUER, N, DWORACKI, G, KANAYA, H, WHITESIDE, T. L

“…It has been suggested that dendritic cells (DCs) are capable of ingesting apoptotic tumor cells (ATCs) and presenting tumor-associated antigens to immune…”
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Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity by de Bono, J. S., Rha, S. Y., Stephenson, J., Schultes, B. C., Monroe, P., Eckhardt, G. S., Hammond, L. A., Whiteside, T. L., Nicodemus, C. F., Cermak, J. M., Rowinsky, E. K., Tolcher, A. W.

“…Background: BrevaRex® mAb-AR20.5 is a murine anti-MUC1 monoclonal antibody generated to induce MUC1 antigen-specific immune responses through the formation of…”
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Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes by GASTMAN, B. R, ATARASHI, Y, REICHERT, T. E, SAITO, T, BALKIR, L, RABINOWICH, H, WHITESIDE, T. L

“…Recent reports have variously described expression of Fas ligand (FasL) or its absence in human tumors. The importance of the Fas-FasL mechanism for the immune…”
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