Search Results - "Whiteley, J. M."

Antibacterial Agents that Inhibit Two-Component Signal Transduction Systems by Barrett, J. F., Goldschmidt, R. M., Lawrence, L. E., Foleno, B., Chen, R., Demers, J. P., Johnson, S., Kanojia, R., Fernandez, J., Bernstein, J., Licata, L., Donetz, A., Huang, S., Hlasta, D. J., Macielag, M. J., Ohemeng, K., Frechette, R., Frosco, M. B., Klaubert, D. H., Whiteley, J. M., Wang, L., Hoch, J. A.

“…A class of antibacterials has been discovered that inhibits the growth of Gram-positive pathogenic bacteria. RWJ-49815, a representative of a family of…”
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Crystal Structure of Rat Liver Dihydropteridine Reductase by Varughese, Kottayil I., Skinner, Matthew M., Whiteley, John M., Matthews, David A., Xuong, Nguyen H.

“…The structure of a binary complex of dihydropteridine reductase [DHPR; NAD(P)H:6,7-dihydropteridine oxidoreductase, EC 1.6.99.7] with its cofactor, NADH, has…”
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Structural and Mechanistic Characteristics of Dihydropteridine Reductase: A Member of the Tyr-(Xaa)3-Lys-Containing Family of Reductases and Dehydrogenases by Varughese, K. I., Xuong, N. H., Kiefer, P. M., Matthews, D. A., Whiteley, J. M.

“…Dihydropteridine reductase (EC 1.6.99.7) is a member of the recently identified family of proteins known as short-chain dehydrogenases. When the x-ray…”
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Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis by GRIMSLEY, J. K, TJALKENS, R. B, STRAUCH, M. A, BIRD, T. H, SPIEGELMAN, G. B, HOSTOMSKY, Z, WHITELEY, J. M, HOCH, J. A

“…The Spo0A transcription factor is responsible for the initiation of sporulation and is active in transcription only after phosphorylation by a specific signal…”
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Devonian marine incursions into the Orcadian Basin, Scotland by Marshall, J. E. A, Rogers, D. A, Whiteley, M. J

“…BP/Chevron well 14/6-1 drilled in the East Orkney Basin has penetrated Devonian sedimentary rocks which can be dated palynologically as within the latest…”
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The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue by Su, Y, Varughese, K I, Xuong, N H, Bray, T L, Roche, D J, Whiteley, J M

“…A human dihydropteridine reductase (EC 1.6.99.10) has been created from a rat cDNA clone by a single five-oligonucleotide mutagenesis reaction and expressed in…”
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Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement by GRIMSHAW, C. E, MATTHEWS, D. A, VARUGHESE, K. I, SKINNER, M, XUONG, N. H, BRAY, T, HOCH, J, WHITELEY, J. M

“…Kinetic constants for the interaction of NADH and NADPH with native rat dihydropteridine reductase (DHPR) and an Escherichia coli expressed mutant (D-37-I)…”
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Purification and preliminary crystallographic studies on the sporulation response regulatory phosphotransferase protein, spo0B, from Bacillus subtilis by Zhou, Xiao Zhen, Whiteley, J.M., Hoch, J.A., Varughese, K.I.

“…The phosphotransferase protein Spo0B, a component of the sporulation signal transduction system in Bacillus subtilis was expressed from the Escherichia coli…”
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Altered Structural and Mechanistic Properties of Mutant Dihydropteridine Reductases (∗) by Kiefer, Philip M., Varughese, Kottayil I., Su, Ying, Xuong, Nguyen-H., Chang, Chi-F., Gupta, Poonam, Bray, Tom, Whiteley, John M.

“…Nine single genetic mutants of rat dihydropteridine reductase (EC 1.6.99.7), D37I, W86I, Y146F, Y146H, K150Q, K150I, K150M, N186A, and A133S and one double…”
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Formation of a Novel Four-Helix Bundle and Molecular Recognition Sites by Dimerization of a Response Regulator Phosphotransferase by Varughese, Kottayil I., Madhusudan, Zhou, Xiao Zhen, Whiteley, John M., Hoch, James A.

“…A basis for understanding specificity of molecular recognition between phosphorelay proteins has been deduced from the 2.6 Å structure of the Spo0B…”
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Comparative properties of three pteridine reductases by Chang, C F, Bray, T, Varughese, K I, Whiteley, J M

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Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase by Shahbaz, M, Hoch, JA, Trach, KA, Hural, JA, Webber, S, Whiteley, JM

“…The cleavage of reductively alkylated rat liver dihydropteridine reductase with cyanogen bromide afforded a mixture of peptides, six of which (CB-1 to CB-6)…”
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Preliminary x-ray diffraction characterization of crystalline rat liver dihydropteridine reductase by Matthews, D A, Webber, S, Whiteley, J M

“…The pyridine dinucleotide-dependent dihydropteridine reductase from rat liver has been crystallized from various inorganic salts and from polyethylene…”
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Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase by Matthews, D A, Varughese, K I, Skinner, M, Xuong, N H, Hoch, J, Trach, K, Schneider, M, Bray, T, Whiteley, J M

“…Full-length rat dihydropteridine reductase (DHPR) cDNAs have been combined with a prokaryotic expression vector and introduced into Escherichia coli…”
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Is dihydropteridine reductase an anomalous dihydrofolate reductase, a flavin-like enzyme, or a short-chain dehydrogenase? by Whiteley, J M, Xuong, N H, Varughese, K I

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Synergistic Kinetic Interactions between Components of the Phosphorelay Controlling Sporulation in Bacillus subtilis by Grimshaw, Charles E, Huang, Shaoming, Hanstein, Conrad G, Strauch, Mark A, Burbulys, David, Wang, Ling, Hoch, James A, Whiteley, John M

“…The four individual phosphotransfer steps in the multicomponent phosphorelay system controlling sporulation in Bacillus subtilis have been characterized…”
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Aspartyl phosphates in the regulatory control of bacterial response by Cavanagh, J, Zapf, J, Hoch, J A, Feher, V, Dahlquist, F W, Whiteley, J M

“…Acyl phosphates represent a mixed anhydride class of compounds whose lability allows the phosphorylation of an aspartyl carboxyl contained in a protein to…”
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Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate by Balinska, M, Rhee, M, Whiteley, J M, Priest, D G, Galivan, J

“…Reduced derivatives of 10-formylfolate have been evaluated as inhibitors of mammalian thymidylate synthase (EC 2.1.1.45) from H35 hepatoma cells. With…”
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A phosphotransferase activity of the Bacillus subtilis sporulation protein SpoOF that employs phosphoramidate substrates by Zapf, J W, Hoch, JA, Whiteley, J M

“…Transient phosphorylation at an aspartate residue on the SpoOF protein is a central step in the phosphorelay signal transduction pathway controlling…”
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Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines by Webber, S, Whiteley, J M

“…The various interactions of rat liver dihydrofolate reductase with two unconjugated 7,8-dihydropteridines, 7,8-dihydrobiopterin and…”
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