Search Results - "Whiteley, Aaron T"

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance by Zhou, Wen, Whiteley, Aaron T., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Mekalanos, John J., Kranzusch, Philip J.

“…Cyclic GMP–AMP synthase (cGAS) recognition of cytosolic DNA is critical for immune responses to pathogen replication, cellular stress, and cancer. Existing…”
Get full text

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp by Whiteley, Aaron T., Pollock, Alex J., Portnoy, Daniel A.

“…Cyclic di-adenosine monophosphate (c-di-AMP) is a widely distributed second messenger that appears to be essential in multiple bacterial species, including the…”
Get full text

An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression by Reniere, Michelle L, Whiteley, Aaron T, Portnoy, Daniel A

“…Listeria monocytogenes is an environmental saprophyte and facultative intracellular bacterial pathogen with a well-defined life-cycle that involves escape from…”
Get full text

Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection by Witte, Chelsea E, Whiteley, Aaron T, Burke, Thomas P, Sauer, John-Demian, Portnoy, Daniel A, Woodward, Joshua J

“…Listeria monocytogenes infection leads to robust induction of an innate immune signaling pathway referred to as the cytosolic surveillance pathway (CSP),…”
Get full text

A Redox-Responsive Transcription Factor Is Critical for Pathogenesis and Aerobic Growth of Listeria monocytogenes by Whiteley, Aaron T, Ruhland, Brittany R, Edrozo, Mauna B, Reniere, Michelle L

“…Bacterial pathogens have evolved sophisticated mechanisms to sense and adapt to redox stress in nature and within the host. However, deciphering the redox…”
Get full text

(p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes by Peterson, Bret N, Young, Megan K M, Luo, Shukun, Wang, Jeffrey, Whiteley, Aaron T, Woodward, Joshua J, Tong, Liang, Wang, Jue D, Portnoy, Daniel A

“…The facultative intracellular pathogen , like many related , uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient…”
Get full text

Conservation and similarity of bacterial and eukaryotic innate immunity by Ledvina, Hannah E., Whiteley, Aaron T.

“…Pathogens are ubiquitous and a constant threat to their hosts, which has led to the evolution of sophisticated immune systems in bacteria, archaea and…”
Get full text

Author Correction: Conservation and similarity of bacterial and eukaryotic innate immunity by Ledvina, Hannah E., Whiteley, Aaron T.

Get full text

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals by Whiteley, Aaron T., Eaglesham, James B., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Lowey, Brianna, Nieminen, Eric A., Danilchanka, Olga, King, David S., Lee, Amy S. Y., Mekalanos, John J., Kranzusch, Philip J.

“…Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit…”
Get full text

Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity by Lau, Rebecca K., Ye, Qiaozhen, Birkholz, Erica A., Berg, Kyle R., Patel, Lucas, Mathews, Ian T., Watrous, Jeramie D., Ego, Kaori, Whiteley, Aaron T., Lowey, Brianna, Mekalanos, John J., Kranzusch, Philip J., Jain, Mohit, Pogliano, Joe, Corbett, Kevin D.

“…Bacteria possess an array of defenses against foreign invaders, including a broadly distributed bacteriophage defense system termed CBASS (cyclic…”
Get full text

Glutathione activates virulence gene expression of an intracellular pathogen by Reniere, Michelle L., Whiteley, Aaron T., Hamilton, Keri L., John, Sonya M., Lauer, Peter, Brennan, Richard G., Portnoy, Daniel A.

“…Intracellular pathogens are responsible for much of the world-wide morbidity and mortality due to infectious diseases. To colonize their hosts successfully,…”
Get full text

CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection by Lowey, Brianna, Whiteley, Aaron T., Keszei, Alexander F.A., Morehouse, Benjamin R., Mathews, Ian T., Antine, Sadie P., Cabrera, Victor J., Kashin, Dmitry, Niemann, Percy, Jain, Mohit, Schwede, Frank, Mekalanos, John J., Shao, Sichen, Lee, Amy S.Y., Kranzusch, Philip J.

“…cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral responses in…”
Get full text

An E1–E2 fusion protein primes antiviral immune signalling in bacteria by Ledvina, Hannah E., Ye, Qiaozhen, Gu, Yajie, Sullivan, Ashley E., Quan, Yun, Lau, Rebecca K., Zhou, Huilin, Corbett, Kevin D., Whiteley, Aaron T.

“…In all organisms, innate immune pathways sense infection and rapidly activate potent immune responses while avoiding inappropriate activation (autoimmunity)…”
Get full text

Bacterial NLR-related proteins protect against phage by Kibby, Emily M., Conte, Amy N., Burroughs, A. Maxwell, Nagy, Toni A., Vargas, Jose A., Whalen, Lindsay A., Aravind, L., Whiteley, Aaron T.

“…Bacteria use a wide range of immune pathways to counter phage infection. A subset of these genes shares homology with components of eukaryotic immune systems,…”
Get full text

c‐di‐AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation by Whiteley, Aaron T., Garelis, Nicholas E., Peterson, Bret N., Choi, Philip H., Tong, Liang, Woodward, Joshua J., Portnoy, Daniel A.

“…Summary Cyclic diadenosine monophosphate (c‐di‐AMP) is a conserved nucleotide second messenger critical for bacterial growth and resistance to cell wall‐active…”
Get full text

The Linguistics of Bacterial Conflict Systems Reveal Ancient Origins of Eukaryotic Innate Immunity by Kibby, Emily M, Whiteley, Aaron T

“…The arms race between bacteria and their competitors has produced an astounding variety of conflict systems that are shared via horizontal gene transfer across…”
Get full text

Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense by Govande, Apurva A., Duncan-Lowey, Brianna, Eaglesham, James B., Whiteley, Aaron T., Kranzusch, Philip J.

“…cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are signaling proteins that initiate antiviral immunity in animal cells and…”
Get full text

A eukaryotic-like ubiquitination system in bacterial antiviral defence by Chambers, Lydia R., Ye, Qiaozhen, Cai, Jiaxi, Gong, Minheng, Ledvina, Hannah E., Zhou, Huilin, Whiteley, Aaron T., Suhandynata, Raymond T., Corbett, Kevin D.

“…Ubiquitination pathways have crucial roles in protein homeostasis, signalling and innate immunity 1 – 3 . In these pathways, an enzymatic cascade of E1, E2 and…”
Get full text

Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy by Mitchell, Gabriel, Cheng, Mandy I., Chen, Chen, Nguyen, Brittney N., Whiteley, Aaron T., Kianian, Sara, Cox, Jeffery S., Green, Douglas R., McDonald, Kent L., Portnoy, Daniel A.

“…Xenophagy is a selective macroautophagic process that protects the host cytosol by entrapping and delivering microbes to a degradative compartment. Both…”
Get full text

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling by Chang, Denis, Whiteley, Aaron T., Gwilt, Katlynn Bugda, Lencer, Wayne I., Mekalanos, John J., Thiagarajah, Jay R.

“…Cyclic dinucleotides (CDNs) are secondary messengers used by prokaryotic and eukaryotic cells. In mammalian cells, cytosolic CDNs bind STING (stimulator of IFN…”
Get full text