Search Results - "Whitehouse, Darren"

Discovery of N‑Substituted 3‑Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II by Van Zandt, Michael C, Jagdmann, G. Erik, Whitehouse, Darren L, Ji, Minkoo, Savoy, Jennifer, Potapova, Olga, Cousido-Siah, Alexandra, Mitschler, Andre, Howard, Eduardo I, Pyle, Anna Marie, Podjarny, Alberto D

“…Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of…”
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Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury by Van Zandt, Michael C, Whitehouse, Darren L, Golebiowski, Adam, Ji, Min Koo, Zhang, Mingbao, Beckett, R. Paul, Jagdmann, G. Erik, Ryder, Todd R, Sheeler, Ryan, Andreoli, Monica, Conway, Bruce, Mahboubi, Keyvan, D’Angelo, Gerard, Mitschler, Andre, Cousido-Siah, Alexandra, Ruiz, Francesc X, Howard, Eduardo I, Podjarny, Alberto D, Schroeter, Hagen

“…Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent…”
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Vibrotactile thresholds at the fingertip, volar forearm, large toe, and heel by Morioka, Miyuki, Whitehouse, Darren J., Griffin, Michael J.

“…Thresholds for the perception of vibration vary with location on the body due to the organization of tactile channels in hairy and non-hairy skin, and…”
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P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis by TAYLOR, Simon R. J, TURNER, Clare M, PUSEY, Charles D, UNWIN, Robert J, TAM, Frederick W. K, ELLIOTT, James I, MCDAID, John, HEWITT, Reiko, SMITH, Jennifer, PICKERING, Matthew C, WHITEHOUSE, Darren L, TERENCE COOK, H, BURNSTOCK, Geoffrey

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P2X7 deficiency attenuates renal injury in experimental glomerulonephritis by Taylor, Simon R J, Turner, Clare M, Elliott, James I, McDaid, John, Hewitt, Reiko, Smith, Jennifer, Pickering, Matthew C, Whitehouse, Darren L, Cook, H Terence, Burnstock, Geoffrey, Pusey, Charles D, Unwin, Robert J, Tam, Frederick W K

“…The P2X7 receptor is a ligand-gated cation channel that is normally expressed by a variety of immune cells, including macrophages and lymphocytes. Because it…”
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Effect of contact location on vibrotactile thresholds at the fingertip by Whitehouse, Darren J., Morioka, Miyuki, Griffin, Michael J.

“…Vibrotactile thresholds depend on the characteristics of the vibration, the location of contact with the skin, and the geometry of the contact with the skin…”
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A comparison of vibrotactile thresholds obtained using different diagnostic equipment: the effect of contact conditions by WHITEHOUSE, Darren J, GRIFFIN, Michael J

“…Vibrotactile thresholds on the fingers were compared using two alternative methods of controlling contact with a vibrating probe: control of the force of…”
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Transition-metal-mediated reactions in combinatorial synthesis by Andres, CJ, Whitehouse, Darren L, Deshpande, Milind S

“…Transition-metal-mediated reactions have played an important role in expanding the scope of combinatorial chemistry from synthesis of peptidic libraries to…”
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Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction by Golebiowski, Adam, Whitehouse, Darren, Beckett, R. Paul, Van Zandt, Michael, Ji, Min Koo, Ryder, Todd R., Jagdmann, Erik, Andreoli, Monica, Lee, Yung, Sheeler, Ryan, Conway, Bruce, Olczak, Jacek, Mazur, Marzena, Czestkowski, Wojciech, Piotrowska, Wieslawa, Cousido-Siah, Alexandra, Ruiz, Francesc X., Mitschler, Andre, Podjarny, Alberto, Schroeter, Hagen

“…The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the…”
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An improved synthesis and selective coupling of a hydroxy based photolabile linker for solid phase organic synthesis by Whitehouse, Darren L., Savinov, Sergey N., Austin, David J.

“…Photolabile linkers have become an important orthogonal technique for substrate cleavage off the resin in solid-phase organic synthesis. Herein, we report an…”
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2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors by Golebiowski, Adam, Paul Beckett, R., Van Zandt, Michael, Ji, Min Koo, Whitehouse, Darren, Ryder, Todd R., Jagdmann, Erik, Andreoli, Monica, Mazur, Adam, Padmanilayam, Manyian, Cousido-Siah, Alexandra, Mitschler, Andre, Ruiz, Francesc X., Podjarny, Alberto, Schroeter, Hagen

“…Substitution at the alpha center of the known human arginase inhibitor 2-amino-6-boronohexanoic acid (ABH) is acceptable in the active site pockets of both…”
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Synthesis of quaternary I--amino acid-based arginase inhibitors via the Ugi reaction by Golebiowski, Adam, Whitehouse, Darren, Beckett, R, Zandt, Michael, Ji, Min, Ryder, Todd, Jagdmann, Erik, Andreoli, Monica, Lee, Yung, Sheeler, Ryan, Conway, Bruce, Olczak, Jacek, Mazur, Marzena, Czestkowski, Wojciech, Piotrowska, Wieslawa, Cousido-Siah, Alexandra, Ruiz, Francesc, Mitschler, Andre, Podjarny, Alberto, Schroeter, Hagen

“…The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the…”
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Time and Tissue Specific Insulin Sensitization in Response to a PPAR-[alpha] Agonist, a PPAR-[gamma] Agonist, and a PTP-1b Inhibitor in High Fat Fed Rats after 1 and 10 Day Treatments by Dean, David, Fan, John, Whitehouse, Darren, Balkan, Börk

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Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74 by Mahboubi, Keyvan, Witman-Jones, Terri, Adamus, Jean E., Letsinger, Jack T., Whitehouse, Darren, Moorman, Allan R., Sawicki, Diane, Bergenhem, Nils, Ross, Stuart A.

“…Niacin is known to exert profound beneficial effects on cholesterol levels in humans, although its use is somewhat hampered by the gram quantities necessary to…”
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A chemoselective rhodium(II) mediated solid phase 1,3-dipolar cycloaddition and its application to a thermally self-cleaving furan scaffold by Whitehouse, Darren L., Nelson, Kingsley H., Savinov, Sergey N., Austin, David J.

“…A chemoselective rhodium(II) mediated 1,3-dipolar cycloaddition reaction on solid-phase for the construction of a template-directed scaffold is described. In…”
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A metathetical cycloaddition–cycloreversion approach to the formation of furan scaffold libraries by Whitehouse, Darren L., Nelson, Kingsley H., Savinov, Jr., Sergey N., Löwe, Ralf S., Austin, David J.

“…A general cycloaddition–cycloreversion metathesis procedure for the selective formation of a furan-based template-directed scaffold is described. In addition,…”
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Approaches to the Total Synthesis of Wilfordine by Whitehouse, Darren L

“…(2RS,3SR,4RS,4aRS,8aRS)-3-Diphenylmethylsily1-4a-hydroxymethy1-7-methyl-1-oxo-3,4,4a,5,8,8a-hexahydro-2H-naphthalen-4-diol was prepared from…”
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