Search Results - "Whiteheart, S W"

Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy by Matveeva, E.A, Price, D.A, Whiteheart, S.W, Vanaman, T.C, Gerhardt, G.A, Slevin, J.T

“…Abstract Our previous work has correlated permanent alterations in the rat neurosecretory machinery with epileptogenesis. Such findings highlighted the need…”
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N-Ethylmaleimide-Sensitive Fusion Protein: A Trimeric ATPase Whose Hydrolysis of ATP Is Required for Membrane Fusion by Whiteheart, Sidney W., Rossnagel, Karin, Buhrow, Susan A., Brunner, Michael, Jaenicke, Rainer, Rothman, James E.

“…The NEM-sensitive fusion protein, NSF, together with SNAPs (soluble NSF attachment proteins) and the SNAREs (SNAP receptors), is thought to be generally used…”
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SNAP-23 Is a Target for Calpain Cleavage in Activated Platelets by Rutledge, Tara W., Whiteheart, S.W.

“…The role of calpain in platelet function is generally associated with aggregation and clot retraction. In this report, data are presented to show that one…”
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A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion by Söllner, T, Bennett, M K, Whiteheart, S W, Scheller, R H, Rothman, J E

“…The SNARE hypothesis holds that a transport vesicle chooses its target for fusion when a soluble NSF attachment protein (SNAP) receptor on the vesicle…”
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Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 in dense core granule release by Chen, Dong, Bernstein, Audrey M., Lemons, Paula P., Whiteheart, Sidney W.

“…To characterize the molecular mechanisms of platelet secretion, we focused on the calcium-induced exocytosis of dense core granules. Platelets contain several…”
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VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA by KONDKAR, A. A., BRAY, M. S., LEAL, S. M., NAGALLA, S., LIU, D. J., JIN, Y., DONG, J. F., REN, Q., WHITEHEART, S. W., SHAW, C., BRAY, P. F.

“…Background: Variation in platelet reactivity contributes to disorders of hemostasis and thrombosis, but the molecular mechanisms are not well understood…”
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Regulated secretion in platelets : Identification of elements of the platelet exocytosis machinery by LEMONS, P. P, CHEN, D, BERNSTEIN, A. M, BENNETT, M. K, WHITEHEART, S. W

“…To further characterize the molecular mechanisms of platelet function, we have sought to identify some of the proteins that mediate the secretory events of the…”
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Accumulation of 7S SNARE complexes in hippocampal synaptosomes from chronically kindled rats by Matveeva, E. A., Whiteheart, S. W., Slevin, J. T.

“…Kindling is a model of complex partial epilepsy wherein periodic application of an initially subconvulsive stimulus leads to first limbic and then generalized…”
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SNAP-mediated protein-protein interactions essential for neurotransmitter release by DeBello, W. M, O'Connor, V, Dresbach, T, Whiteheart, S. W, Wang, S. S.-H, Schweizer, F. E, Bertz, H, Rothman, J. E, Augustine, G. J

“…The constitutive fusion of transport vesicles with intracellular membranes requires soluble proteins called SNAPs. Certain presynaptic proteins implicated in…”
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Role of alpha -SNAP in Promoting Efficient Neurotransmission at the Crayfish Neuromuscular Junction by He, Ping, Southard, R. Chase, Chen, Dong, Whiteheart, S. W, Cooper, R. L

“…  1 T. H. Morgan School of Biological Science, University of Kentucky, Lexington 40506-0225; and   2 Department of Biochemistry, University of Kentucky College…”
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Organization of the secretory machinery in the rodent brain: distribution of the t-SNAREs, SNAP-25 and SNAP-23 by Chen, Dong, Minger, Stephen L, Honer, William G, Whiteheart, S.W

“…Vesicular transport events appear to be facilitated by the VAMP/synaptobrevin family of membrane proteins in the vesicle (v-SNAREs) and a heterodimeric complex…”
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Influence of serotonin on the kinetics of vesicular release by Southard, R.Chase, Haggard, J, Crider, M.E, Whiteheart, S.W, Cooper, R.L

“…The mechanisms by which synaptic vesicles are transported and primed to fuse with the presynaptic membrane are important to all chemical synapses. Processes of…”
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A Multisubunit Particle Implicated in Membrane Fusion by Wilson, Duncan W., Whiteheart, Sidney W., Wiedmann, Martin, Brunner, Michael, Rothman, James E.

“…The N-ethylmaleimide sensitive fusion protein (NSF) is required for fusion of lipid bilayers at many locations within eukaryotic cells. Binding of NSF to Golgi…”
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SNAP family of NSF attachment proteins includes a brain-specific isoform by Whiteheart, Sidney W, Griff, Irene C, Brunner, Michael, Clary, Douglas O, Mayer, Thomas, Buhrow, Susan A, Rothman, James E

“…The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. Here we report the cloning and…”
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Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia by Minger, Stephen L, Geddes, James W, Holtz, Mary L, Craddock, Susan D, Whiteheart, Sidney W, Siman, Robert G, Pettigrew, L.Creed

“…Excitatory amino acids may promote microtubular proteolysis observed in ischemic neuronal degeneration by calcium-mediated activation of calpain, a neutral…”
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Reconstitution of transcytosis in SLO‐permeabilized MDCK cells: existence of an NSF‐dependent fusion mechanism with the apical surface of MDCK cells by Apodaca, G., Cardone, M. H., Whiteheart, S. W., DasGupta, B. R., Mostov, K. E.

“…Recently, it was demonstrated that delivery from the trans‐Golgi network (TGN) to the basolateral surface of Madin‐Darby canine kidney (MDCK) cells required…”
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SNAP receptors implicated in vesicle targeting and fusion by Söllner, Thomas, Whiteheart, Sidney W, Brunner, Michael, Erdjument-Bromage, Hediye, Geromanos, Scott, Tempst, Paul, Rothman, James E

“…The N-ethylmaleimide-sensitive fusion protein (NSF) and the soluble NSF attachment proteins (SNAPs) appear to be essential components of the intracellular…”
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Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 and 4 in lysosome release by Chen, Dong, Lemons, Paula P., Schraw, Todd, Whiteheart, Sidney W.

“…On stimulation by strong agonists, platelets release the contents of 3 storage compartments in 2 apparent waves of exocytosis. The first wave is the release of…”
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Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes by Whiteheart, S W, Brunner, M, Wilson, D W, Wiedmann, M, Rothman, J E

“…Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) are required for the binding of N-ethylmaleimide-sensitive fusion protein (NSF) to Golgi…”
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Crystal Structure of the Hexamerization Domain of N-ethylmaleimide–Sensitive Fusion Protein by Lenzen, Christian U., Steinmann, Diana, Whiteheart, Sidney W., Weis, William I.

“…N-ethylmaleimide–sensitive fusion protein (NSF) is a cytosolic ATPase required for many intracellular vesicle fusion reactions. NSF consists of an…”
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