Search Results - "Whitehead, Robert H."

Establishment of conditionally immortalized epithelial cell lines from the intestinal tissue of adult normal and transgenic mice by Whitehead, Robert H, Robinson, Pamela S

“…It has proved to be impossible to culture epithelial cells from the gastrointestinal tract of adult animals. Researchers have had to use either cell lines…”
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Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage–stellate cell interaction by Shi, Chanjuan, Washington, M Kay, Chaturvedi, Rupesh, Drosos, Yiannis, Revetta, Frank L, Weaver, Connie J, Buzhardt, Emily, Yull, Fiona E, Blackwell, Timothy S, Sosa-Pineda, Beatriz, Whitehead, Robert H, Beauchamp, R Daniel, Wilson, Keith T, Means, Anna L

“…Pancreatic cancer occurs in the setting of a profound fibrotic microenvironment that often dwarfs the actual tumor. Although pancreatic fibrosis has been well…”
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Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration by Dise, Rebecca S, Frey, Mark R, Whitehead, Robert H, Polk, D Brent

“…Regulated intestinal epithelial cell migration plays a key role in wound healing and maintenance of a healthy gastrointestinal tract. Epidermal growth factor…”
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Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach by Weis, Victoria G, Petersen, Christine P, Mills, Jason C, Tuma, Pamela L, Whitehead, Robert H, Goldenring, James R

“…Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic polypeptide expressing metaplasia (SPEM). Investigations of…”
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Epidermal growth factor receptor regulates pancreatic fibrosis by Blaine, Stacy A, Ray, Kevin C, Branch, Kevin M, Robinson, Pamela S, Whitehead, Robert H, Means, Anna L

“…The development of pancreatic fibrosis has been shown to be a major component in several diseases of the pancreas including pancreatic cancer, chronic…”
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Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B‐Raf by Zhang, Hui‐Hua, Walker, Francesca, Kiflemariam, Sara, Whitehead, Robert H., Williams, David, Phillips, Wayne A., Mikeska, Thomas, Dobrovic, Alexander, Burgess, Antony W.

“…Tumor‐derived cell lines are indispensable tools for understanding the contribution of activated signaling pathways to the cancer phenotype and for the design…”
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Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression by Fujimoto, Koji, Beauchamp, R.Daniel, Whitehead, Robert H.

“…Background & Aims: The surface epithelium of the colon is being replaced constantly with cells derived from the stem cells of the crypt. Although the location…”
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Simian Virus 40 T-Antigen-Mediated Gene Regulation in Enterocytes Is Controlled Primarily by the Rb-E2F Pathway by Rathi, Abhilasha V., Sáenz Robles, M. Teresa, Cantalupo, Paul G., Whitehead, Robert H., Pipas, James M.

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Identification of Early Intestinal Neoplasia Protein Biomarkers Using Laser Capture Microdissection and MALDI MS by Xu, Baogang J, Li, Jiaqing, Beauchamp, R Daniel, Shyr, Yu, Li, Ming, Washington, M Kay, Yeatman, Timothy J, Whitehead, Robert H, Coffey, Robert J, Caprioli, Richard M

“…Obtaining protein profiles from a homogeneous cell population in tissues can significantly improve our capability in protein biomarker discovery. In this…”
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Intestinal Hyperplasia Induced by Simian Virus 40 Large Tumor Antigen Requires E2F2 by SAENZ-ROBLES, M. Teresa, MARKOVICS, Jennifer A, CHONG, Jean-Leon, OPAVSKY, Rene, WHITEHEAD, Robert H, LEONE, Gustavo, PIPAS, James M

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Mtgr1 Is a Transcriptional Corepressor That Is Required for Maintenance of the Secretory Cell Lineage in the Small Intestine by Amann, Joseph M., Chyla, Brenda J. Irvin, Ellis, Tiffany C., Martinez, Andres, Moore, Amy C., Franklin, Jeffrey L., McGhee, Laura, Meyers, Shari, Ohm, Joyce E., Luce, K. Scott, Ouelette, Andre J., Washington, M. Kay, Thompson, Mary Ann, King, Dana, Gautam, Shiva, Coffey, Robert J., Whitehead, Robert H., Hiebert, Scott W.

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The Human A33 Antigen is a Transmembrane Glycoprotein and a Novel Member of the Immunoglobulin Superfamily by Heath, Joan K., White, Sara J., Johnstone, Cameron N., Catimel, Bruno, Simpson, Richard J., Moritz, Robert L., Tu, Guo-Fen, Ji, Hong, Whitehead, Robert H., Groenen, Leo C., Scott, Andrew M., Ritter, Gerd, Cohen, Leonard, Welt, Sydney, Old, Lloyd J., Nice, Edouard C., Burgess, Antony W.

“…The mAb A33 detects a membrane antigen that is expressed in normal human colonic and small bowel epithelium and >95% of human colon cancers. It is absent from…”
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The phosphatidylinositol 3'-kinase p85α gene is an oncogene in human ovarian and colon tumors by PHILP, Amanda J, CAMPBELL, Ian G, LEET, Christine, VINCAN, Elizabeth, ROCKMAN, Steven P, WHITEHEAD, Robert H, THOMAS, Robert J. S, PHILLIPS, Wayne A

“…Phosphatidylinositol 3'-kinases (PI3ks) are a family of lipid kinases that play a crucial role in a wide range of important cellular processes associated with…”
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Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA by Franklin, Jeffrey L., Rankin, Carl R., Levy, Shawn, Snoddy, Jay R., Zhang, Bing, Washington, Mary Kay, Thomson, J. Michael, Whitehead, Robert H., Coffey, Robert J.

“…•Non-coding RNAs are found in the colonic crypt progenitor compartment.•Colonocytes transformed by ncNRFR are highly invasive and metastatic.•ncNRFR has a…”
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Stimulated Shedding of Vascular Cell Adhesion Molecule 1 (VCAM-1) Is Mediated by Tumor Necrosis Factor-α-converting Enzyme (ADAM 17) by Garton, Kyle J., Gough, Peter J., Philalay, Julie, Wille, Paul T., Blobel, Carl P., Whitehead, Robert H., Dempsey, Peter J., Raines, Elaine W.

“…A variety of cell surface adhesion molecules can exist as both transmembrane proteins and soluble circulating forms. Increases in the levels of soluble…”
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Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells by Tran, C P, Familari, M, Parker, L M, Whitehead, R H, Giraud, A S

“…Intestinal trefoil factor (ITF) gene expression was detected in five colon cancer cell lines. ITF was synthesized by mucous cells of LIM 1215 and LIM 1863…”
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Unlike Esophageal Squamous Cells, Barrett's Epithelial Cells Resist Apoptosis by Activating the Nuclear Factor-κB Pathway by HORMI-CARVER, Kathy, XI ZHANG, HUI YING ZHANG, WHITEHEAD, Robert H, TERADA, Lance S, SPECHLER, Stuart J, SOUZA, Rhonda F

“…Abstract Apoptosis is an important mechanism for maintaining tissue homeostasis and for preventing the proliferation of cells with mutations that could result…”
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436d A Novel In Vitro SPEM Culture Provides a Model for Characterization of Metaplasia in the Stomach by Weis, Victoria G, Petersen, Christine, Nam, Ki Taek, Tuma, Pamela L, Whitehead, Robert H, Goldenring, James R

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Conditionally immortalized mouse hepatocytes for use in liver gene therapy by Allen, K J, Reyes, R, Demmler, K, Mercer, J F, Williamson, R, Whitehead, R H

“…The use of hepatocytes for gene therapy is limited by the difficulty of maintaining and altering primary liver cells in culture. A conditionally immortalized…”
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Cell-type specific regulation of gene expression by simian virus 40 T antigens by Cantalupo, Paul G, Sáenz-Robles, Maria Teresa, Rathi, Abhilasha V, Beerman, Rebecca W, Patterson, William H, Whitehead, Robert H, Pipas, James M

“…Abstract SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while…”
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