Search Results - "Whitehall, V L J"

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients by Wockner, L F, Noble, E P, Lawford, B R, Young, R McD, Morris, C P, Whitehall, V L J, Voisey, J

“…Recent studies suggest that genetic and environmental factors do not account for all the schizophrenia risk, and epigenetics also has a role in disease…”
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Brain-specific epigenetic markers of schizophrenia by Wockner, L F, Morris, C P, Noble, E P, Lawford, B R, Whitehall, V L J, Young, R M, Voisey, J

“…Epigenetics plays a crucial role in schizophrenia susceptibility. In a previous study, we identified over 4500 differentially methylated sites in prefrontal…”
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DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer by Worthley, D L, Whitehall, V L J, Buttenshaw, R L, Irahara, N, Greco, S A, Ramsnes, I, Mallitt, K -A, Le Leu, R K, Winter, J, Hu, Y, Ogino, S, Young, G P, Leggett, B A

“…There are two major molecular pathways to sporadic colorectal cancer, the chromosomal instability (CIN) and the CpG island methylator phenotype (CIMP)…”
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BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum by Kambara, T, Simms, L A, Whitehall, V L J, Spring, K J, Wynter, C V A, Walsh, M D, Barker, M A, Arnold, S, McGivern, A, Matsubara, N, Tanaka, N, Higuchi, T, Young, J, Jass, J R, Leggett, B A

“…Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC) showing high level microsatellite instability (MSI-H). However, the…”
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Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype by Whitehall, V L J, Dumenil, T D, McKeone, D M, Bond, C E, Bettington, M L, Buttenshaw, R L, Bowdler, L, Montgomery, G W, Wockner, L F, Leggett, B A

“…The CpG Island Methylator Phenotype (CIMP) is fundamental to an important subset of colorectal cancer; however, its cause is unknown. CIMP is associated with…”
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APC mutation and tumour budding in colorectal cancer by Jass, J R, Barker, M, Fraser, L, Walsh, M D, Whitehall, V L J, Gabrielli, B, Young, J, Leggett, B A

“…Aim: To determine the frequency of tumour budding and somatic APC mutation in a series of colorectal cancers stratified according to DNA microsatellite…”
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Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer by McGivern, A, Wynter, C V A, Whitehall, V L J, Kambara, T, Spring, K J, Walsh, M D, Barker, M A, Arnold, S, Simms, L A, Leggett, B A, Young, J, Jass, J R

“…Colorectal cancers resulting from defective DNA mismatch repair can occur in both hereditary non-polyposis colon cancer (HNPCC) and in the sporadic setting…”
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Re: Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study by Worthley, Daniel L., Hewett, David G., Spring, Kevin J., Whitehall, Vicki L. J., Leggett, Barbara A.

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p73 Is up‐regulated in a subset of hepatocellular carcinomas by Herath, Nirmitha I., Kew, Michael C., Whitehall, Vicki L., Walsh, Michael D., Jass, Jeremy R., Khanna, Kum Kum, Young, Joanne, Powell, Lawrie W., Leggett, Barbara A., Macdonald, Graeme A.

“…Loss of heterozygosity (LOH) at 1p36 occurs in a number of solid tumors including hepatocellular carcinoma (HCC). Recently, a novel gene, p73, has been…”
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