Search Results - "Whiteaker, K L"

Characterization of a novel ATP‐sensitive K+ channel opener, A‐251179, on urinary bladder relaxation and cystometric parameters by Shieh, C‐C, Brune, M E, Buckner, S A, Whiteaker, K L, Molinari, E J, Milicic, I A, Fabiyi, A C, Daza, A, Brioni, J D, Carroll, W A, Matsushita, K, Yamada, M, Kurachi, Y, Gopalakrishnan, M

“…Background and Purpose: ATP‐sensitive K+ channels (KATP) play a pivotal role in contractility of urinary bladder smooth muscle. This study reports the…”
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Validation of FLIPR membrane potential dye for high throughput screening of potassium channel modulators by Whiteaker, K L, Gopalakrishnan, S M, Groebe, D, Shieh, C C, Warrior, U, Burns, D J, Coghlan, M J, Scott, V E, Gopalakrishnan, M

“…A fluorescence-based assay using the FLIPR Membrane Potential Assay Kit (FMP) was evaluated for functional characterization and high throughput screening (HTS)…”
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Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK‐293 cells by Gopalakrishnan, Murali, Molinari, Eduardo J, Shieh, Char‐Chang, Monteggia, Lisa M, Roch, Jean‐Marc, Whiteaker, Kristi L, Scott, Victoria E S, Sullivan, James P, Brioni, Jorge D

“…The pharmacological properties of KATP channels generated by stable co‐expression of the sulphonylurea receptor SUR1 and the inwardly rectifying K+ channel…”
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Pharmacological and molecular characterization of ATP-sensitive K + channels in the TE671 human medulloblastoma cell line by Miller, Thomas R, Taber, Rachel Davis, Molinari, Eduardo J, Whiteaker, Kristi L, Monteggia, Lisa M, Scott, Victoria E.S, Brioni, Jorge D, Sullivan, James P, Gopalakrishnan, Murali

“…ATP-sensitive K + (K ATP) channels in the human medulloblastoma TE671 cell line were characterized by membrane potential assays utilizing a potentiometric…”
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Cu island growth on Cu(110) by Robinson, I.K., Whiteaker, K.L., Walko, D.A.

“…Submonolayer deposition of a metal upon a well-characterized surface of the same metal can be used to study the properties of surface diffusion. Satellite…”
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Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes by Whiteaker, Kristi L, Davis-Taber, Rachel, Scott, Victoria E.S, Gopalakrishnan, Murali

“…Introduction: Activation of ATP-sensitive K + channels (K ATP) has been shown to induce ischemic preconditioning that serves as a protective mechanism in the…”
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Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells by Gopalakrishnan, M, Whiteaker, K L, Molinari, E J, Davis-Taber, R, Scott, V E, Shieh, C C, Buckner, S A, Milicic, I, Cain, J C, Postl, S, Sullivan, J P, Brioni, J D

“…ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. To investigate the properties of KATP channels…”
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Cell-based assays using the fluorometric imaging plate reader (FLIPR) by Whiteaker, K L, Sullivan, J P, Gopalakrishnan, M

“…A critical component of the drug discovery and development process is the identification of novel pharmacophores. Such discovery efforts are, in general,…”
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Disordered structure of cubic iron silicide films on Si(111) by Whiteaker, KL, Robinson, IK, Benson, C, Smilgies, DM, Onda, N, von Känel H

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Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as K ATP channel openers (KCOs) by Drizin, Irene, Holladay, Mark W., Yi, Lin, Zhang, Henry Q., Gopalakrishnan, Sujatha, Gopalakrishnan, Murali, Whiteaker, Kristi L., Buckner, Steven A., Sullivan, James P., Carroll, William A.

“…A novel series of tricyclic dihydropyrimidines was synthesized and evaluated for activity as K ATP channel openers. The functional activity of several…”
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Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2- b ]quinolin-8(4 H )-one 1,1-Dioxide K ATP Channel Openers:  Discovery of (−)-(9 S )-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2- b ]quinolin-8(4 H )-one 1,1-Dioxide (A-278637), a Potent K ATP Opener That Selectively Inhibits Spontaneous Bladder Contractions by Carroll, William A., Altenbach, Robert J., Bai, Hao, Brioni, Jorge D., Brune, Michael E., Buckner, Steven A., Cassidy, Christopher, Chen, Yiyuan, Coghlan, Michael J., Daza, Anthony V., Drizin, Irene, Fey, Thomas A., Fitzgerald, Michael, Gopalakrishnan, Murali, Gregg, Robert J., Henry, Rodger F., Holladay, Mark W., King, Linda L., Kort, Michael E., Kym, Philip R., Milicic, Ivan, Tang, Rui, Turner, Sean C., Whiteaker, Kristi L., Yi, Lin, Zhang, Henry, Sullivan, James P.

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Synthesis and Structure−Activity Relationships of a Novel Series of Tricyclic Dihydropyridine-Based K ATP Openers That Potently Inhibit Bladder Contractions in Vitro by Carroll, William A., Agrios, Konstantinos A., Altenbach, Robert J., Buckner, Steven A., Chen, Yiyuan, Coghlan, Michael J., Daza, Anthony V., Drizin, Irene, Gopalakrishnan, Murali, Henry, Rodger F., Kort, Michael E., Kym, Philip R., Milicic, Ivan, Smith, Jamie C., Tang, Rui, Turner, Sean C., Whiteaker, Kristi L., Zhang, Henry, Sullivan, James P.

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Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers by DRIZIN, Irene, ALTENBACH, Robert J, CARROLL, William A, BUCKNER, Steven A, WHITEAKER, Kristi L, SCOTT, Victoria E, DARBYSHIRE, John F, JAYANTI, Venkata, HENRY, Rodger F, COGHLAN, Michael J, GOPALAKRISHNAN, Murali

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Characterization of human urinary bladder K ATP channels containing SUR2B splice variants expressed in L-cells by Scott, Victoria E, Davis-Taber, Rachel A, Silvia, Christopher, Hoogenboom, Lisa, Choi, Won, Kroeger, Paul, Whiteaker, Kristi L, Gopalakrishnan, Murali

“…The molecular properties of the sulfonylurea receptor 2 (SUR2) subunits of K ATP channels expressed in urinary bladder were assessed by polymerase chain…”
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(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization by Gopalakrishnan, Murali, Buckner, Steven A, Whiteaker, Kristi L, Shieh, Char-Chang, Molinari, Eduardo J, Milicic, Ivan, Daza, Anthony V, Davis-Taber, Rachel, Scott, Victoria E, Sellers, Donna, Chess-Williams, Russ, Chapple, Christopher R, Liu, Yi, Liu, Dong, Brioni, Jorge D, Sullivan, James P, Williams, Michael, Carroll, William A, Coghlan, Michael J

“…Alterations in the myogenic activity of the bladder smooth muscle are thought to serve as a basis for the involuntary detrusor contractions associated with the…”
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[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding by Davis-Taber, Rachel, Molinari, Eduardo J, Altenbach, Robert J, Whiteaker, Kristi L, Shieh, Char-Chang, Rotert, Gary, Buckner, Steven A, Malysz, John, Milicic, Ivan, McDermott, Jeffrey S, Gintant, Gary A, Coghlan, Michael J, Carroll, William A, Scott, Victoria E, Gopalakrishnan, Murali

“…Although ATP-sensitive K+ channels continue to be explored for their therapeutic potential, developments in high-affinity radioligands to investigate native…”
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Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder by Perez-Medrano, Arturo, Buckner, Steven A., Coghlan, Michael J., Gregg, Robert J., Gopalakrishnan, Murali, Kort, Michael E., Lynch, John K., Scott, Victoria E., Sullivan, James P., Whiteaker, Kristi L., Carroll, William A.

“…Thiourea derivatives were identified as glyburide-reversible potassium channel openers through high-throughput screening. Based on these findings, a number of…”
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In vitro and in vivo characterization of a novel naphthylamide ATP‐sensitive K+ channel opener, A‐151892 by Gopalakrishnan, Murali, Buckner, Steven A, Shieh, Char‐Chang, Fey, Thomas, Fabiyi, Adebola, Whiteaker, Kristi L, Davis‐Taber, Rachel, Milicic, Ivan, Daza, Anthony V, Scott, Victoria E S, Castle, Neil A, Printzenhoff, David, London, Brecht, Turner, Sean C, Carroll, William A, Sullivan, James P, Coghlan, Michael J, Brune, Michael E

“…Openers of ATP‐sensitive K+ channels are of interest in several therapeutic indications including overactive bladder and other lower urinary tract disorders…”
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Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle by Gopalakrishnan, Sujatha M, Buckner, Steven A, Milicic, Ivan, Groebe, Duncan R, Whiteaker, Kristi L, Burns, David J, Warrior, Usha, Gopalakrishnan, Murali

“…Although multiple adenosine receptors have been identified, the subtype and underlying mechanisms involved in the relaxation response to adenosine in the…”
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Pharmacological characterization of a 1,4‐dihydropyridine analogue, 9‐(3,4‐dichlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐1,8(2 H ,5 H )‐acridinedione (A‐184209) as a novel K ATP channel inhibitor by Gopalakrishnan, Murali, Miller, Thomas R, Buckner, Steven A, Milicic, Ivan, Molinari, Eduardo J, Whiteaker, Kristi L, Davis‐Taber, Rachel, Scott, Victoria E, Cassidy, Christopher, Sullivan, James P, Carroll, William A

“…This study reports on the identification and characterization of a 1,4‐dihydropyridine analogue,…”
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