Search Results - "White III, C. L."

Neuropathologic Evidence that the Lewy Body Variant of Alzheimer Disease Represents Coexistence of Alzheimer Disease and Idiopathic Parkinson Disease by Brown, D F, Dababo, M A, Bigio, E H, Risser, R C, Eagan, K P, Hladik, C L, White, C L

“…We undertook this study to investigate the neuropathologic relationships among Alzheimer disease (AD), idiopathic Parkinson disease (PD), and the Lewy body…”
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TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions by Cairns, Nigel J, Neumann, Manuela, Bigio, Eileen H, Holm, Ida E, Troost, Dirk, Hatanpaa, Kimmo J, Foong, Chan, White, Charles L, Schneider, Julie A, Kretzschmar, Hans A, Carter, Deborah, Taylor-Reinwald, Lisa, Paulsmeyer, Katherine, Strider, Jeffrey, Gitcho, Michael, Goate, Alison M, Morris, John C, Mishra, Manjari, Kwong, Linda K, Stieber, Anna, Xu, Yan, Forman, Mark S, Trojanowski, John Q, Lee, Virginia M.-Y, Mackenzie, Ian R.A

“…TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive,…”
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Frontotemporal and motor neurone degeneration with neurofilament inclusion bodies: additional evidence for overlap between FTD and ALS by Bigio, E. H., Lipton, A. M., White III, C. L., Dickson, D. W., Hirano, A.

“…We present the case of a patient who had clinical frontal lobe dementia without apparent motor neurone disease (MND), with pathologic findings not typical of…”
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Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis by SONTAG, ESTELLE, HLADIK, CHRISTA, MONTGOMERY, LISA, LUANGPIROM, AMPA, MUDRAK, INGRID, OGRIS, EGON, WHITE, CHARLES L

“…ABαC, a major protein phosphatase 2A (PP2A) heterotrimeric enzyme, binds to and regulates the microtubule cytoskeleton and tau. We have shown that ABαC protein…”
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Synapse loss is greater in presenile than senile onset Alzheimer disease: implications for the cognitive reserve hypothesis by Bigio, E. H., Hynan, L. S., Sontag, E., Satumtira, S., White III, C. L.

“…In the past, ‘Alzheimer disease’ (AD) referred to pathologic AD with clinical onset of dementia in the presenium, while ‘senile dementia of the Alzheimer type’…”
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TAR DNA-Binding Protein 43 Immunohistochemistry Reveals Extensive Neuritic Pathology in FTLD-U: A Midwest-Southwest Consortium for FTLD Study by Hatanpaa, Kimmo J, Bigio, Eileen H, Cairns, Nigel J, Womack, Kyle B, Weintraub, Sandra, Morris, John C, Foong, Chan, Xiao, Guanghua, Hladik, Christa, Mantanona, Tina Y, White, Charles L

“…TAR DNA-binding protein 43 (TDP-43) is a major component of the inclusions in frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U). We…”
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Pediatric Oligodendrogliomas: A Study of Molecular Alterations on 1p and 19q Using Fluorescence In Situ Hybridization by RAGHAVAN, RAVI, BALANI, JYOTI, PERRY, ARIE, MARGRAF, LINDA, VONO, MARY B, CAI, DAN X, WYATT, ROBERT E, RUSHING, ELISABETH J, BOWERS, DANIEL C, HYNAN, LINDA S, WHITE, CHARLES L

“…Oligodendrogliomas (OGs) are rare in children and have not been well characterized from a molecular viewpoint. In adults, losses on chromosomes 1p and/or 19q…”
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Reduced Binding of Protein Phosphatase 2A to Tau Protein with Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Mutations by Goedert, Michel, Satumtira, Sivapong, Jakes, Ross, Smith, Michael J., Kamibayashi, Craig, White, Charles L., Sontag, Estelle

“…: Coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17). We have previously…”
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Constitutive and regulated expression of the mouse Dinb ( Polκ) gene encoding DNA polymerase kappa by Velasco-Miguel, Susana, Richardson, James A., Gerlach, Valerie L., Lai, Wayne C., Gao, Tianshu, Russell, Lonnie D., Hladik, Christa L., White, Charles L., Friedberg, Errol C.

“…A recently discovered group of novel polymerases are characterized by significantly reduced fidelity of DNA synthesis in vitro. This feature is consistent with…”
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Frontal Lobe Dementia With Novel Tauopathy: Sporadic Multiple System Tauopathy With Dementia by BIGIO, EILEEN H, LIPTON, ANNE M, YEN, SHU-HUI, HUTTON, MIKE L, BAKER, MATT, NACHARAJU, PARIMALA, WHITE, CHARLES L, DAVIES, PETER, LIN, WENLANG, DICKSON, DENNIS W

“…We present a novel tauopathy in a patient with a 10-yr history of progressive frontal lobe dementia and a negative family history. Autopsy revealed mild…”
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Brain Interleukin 1 and S-100 Immunoreactivity are Elevated in Down Syndrome and Alzheimer Disease by Sue, W., Griffin, T., Stanley, Laura C., Ling, Chen, White, Lanya, MacLeod, Veronica, Perrot, Linda J., White, Charles L., Araoz, Carlos

“…Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was present in up to 30 times as…”
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The role of cortical connectivity in Alzheimer's disease pathogenesis: a review and model system by De Lacoste, M C, White, 3rd, C L

“…Here we review current evidence in support of the cortical disconnection/cortical connectivity model of Alzheimer disease (AD) pathogenesis, a model which…”
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Progressive Supranuclear Palsy with Dementia: Cortical Pathology by Bigio, Eileen H, Brown, Daniel F, White, Charles L

“…Patients with progressive supranuclear palsy (PSP) often develop dementia, and cortical pathology has been documented in PSP. However, there are no reports…”
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Beta-Amyloid Precursor Protein Staining in Nonhomicidal Pediatric Medicolegal Autopsies by REICHARD, R ROSS, WHITE, CHARLES L, HLADIK, CHRISTA L, DOLINAK, DAVID

“…Immunohistochemical staining for beta-amyloid precursor protein (βAPP) has been validated as a marker for axonal injury in adults surviving ≥2 hours after…”
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Cortical Synapse Loss in Progressive Supranuclear Palsy by BIGIO, EILEEN H, VONO, MARY BETH, SATUMTIRA, SIVAPONG, ADAMSON, JENNIFER, SONTAG, ESTELLE, HYNAN, LINDA S, WHITE, CHARLES L, BAKER, MATT, HUTTON, MIKE

“…Cortical synapse loss, the probable substrate of cognitive impairment in Alzheimer disease (AD), has not previously been evaluated in progressive supranuclear…”
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Undiagnosed progressive supranuclear palsy in a patient with neuroleptic malignant syndrome due to use of neuroleptics: the utility of autopsy in deaths due to known drug reactions by Kemp, Walter L, Fitzgerald, John, White, 3rd, Charles L

“…Medical examiners must decide whether or not a complete autopsy is warranted in evaluation of deaths that have been referred to their office. This decision is…”
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Altered Expression Levels of the Protein Phosphatase 2A AB[alpha]C Enzyme Are Associated with Alzheimer Disease Pathology by Sontag, Estelle, Luangpirom, Ampa, Hladik, Christa, Mudrak, Ingrid

“…The formation of amyloid-containing senile plaques and tau-rich neurofibrillary tangles are central events in Alzheimer disease (AD) pathogenesis…”
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Neocortical Synapse Density and Braak Stage in the Lewy Body Variant of Alzheimer Disease: A Comparison with Classic Alzheimer Disease and Normal Aging by Brown, Daniel F, Risser, Richard C, Bigio, Eileen H, Tripp, Patrick, Stiegler, Ashley, Welch, Erin, Eagan, Kathleen P, Hladik, Christa L, White, Charles L

“…Substantial numbers of cortical and subcortical Lewy bodies are seen in approximately one quarter of patients whose brains show sufficient histopathologic…”
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Alpha-Synuclein Expression in Central Nervous System Tumors Showing Neuronal or Mixed Neuronal/Glial Differentiation by RAGHAVAN, RAVI, WHITE, CHARLES L, ROGERS, BEVERLY, COIMBRA, CAETANO, RUSHING, ELISABETH J

“…Alpha-synuclein (α-synuclein) is a member of a family of cytoplasmic proteins found predominantly and abundantly in the brain, and concentrated in pre-synaptic…”
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Neurologic complications of bone marrow transplantation by PATCHELL, R. A, WHITE, C. L. III, CLARK, A. W, BESCHORNER, W. E, SANTOS, G. W

“…Among 78 patients who died after bone marrow transplantation, neurologic complications were present in 55 (70%) and were the cause of death in 5 (6%)…”
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