Search Results - "White, Stephanie A"
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Molecular Microcircuitry Underlies Functional Specification in a Basal Ganglia Circuit Dedicated to Vocal Learning
Published in Neuron (Cambridge, Mass.) (09-02-2012)“…Similarities between speech and birdsong make songbirds advantageous for investigating the neurogenetics of learned vocal communication—a complex phenotype…”
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Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds
Published in Frontiers in behavioral neuroscience (25-02-2022)“…The molecular mechanisms underlying learned vocal communication are not well characterized. This is a major barrier for developing treatments for conditions…”
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3
Striatal FoxP2 is actively regulated during songbird sensorimotor learning
Published in PloS one (06-01-2010)“…Mutations in the FOXP2 transcription factor lead to language disorders with developmental onset. Accompanying structural abnormalities in cortico-striatal…”
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Distribution of language-related Cntnap2 protein in neural circuits critical for vocal learning
Published in Journal of comparative neurology (1911) (01-01-2014)“…ABSTRACT Variants of the contactin associated protein‐like 2 (Cntnap2) gene are risk factors for language‐related disorders including autism spectrum disorder,…”
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VoICE: A semi-automated pipeline for standardizing vocal analysis across models
Published in Scientific reports (28-05-2015)“…The study of vocal communication in animal models provides key insight to the neurogenetic basis for speech and communication disorders. Current methods for…”
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Revised nomenclature for avian telencephalon and some related brainstem nuclei
Published in Journal of comparative neurology (1911) (31-05-2004)“…The standard nomenclature that has been used for many telencephalic and related brainstem structures in birds is based on flawed assumptions of homology to…”
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JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse
Published in Neuron (Cambridge, Mass.) (16-12-2015)“…Autism spectrum disorder (ASD) is a heritable, common neurodevelopmental disorder with diverse genetic causes. Several studies have implicated protein…”
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Vocalization Deficits in Mice Over-Expressing Alpha-Synuclein, a Model of Pre-Manifest Parkinson's Disease
Published in Behavioral neuroscience (01-04-2014)“…Communication and swallowing deficits are common in Parkinson's disease (PD). Evidence indicates that voice and speech dysfunction manifest early, prior to…”
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A Molecular Neuroethological Approach for Identifying and Characterizing a Cascade of Behaviorally Regulated Genes
Published in Proceedings of the National Academy of Sciences - PNAS (10-10-2006)“…Songbirds have one of the most accessible neural systems for the study of brain mechanisms of behavior. However, neuroethological studies in songbirds have…”
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FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
Published in eLife (23-01-2018)“…Human speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely…”
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Distinct neurogenomic states in basal ganglia subregions relate differently to singing behavior in songbirds
Published in PLoS computational biology (01-11-2012)“…Both avian and mammalian basal ganglia are involved in voluntary motor control. In birds, such movements include hopping, perching and flying. Two…”
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Birdsong Decreases Protein Levels of FoxP2, a Molecule Required for Human Speech
Published in Journal of neurophysiology (01-10-2008)“…1 Department of Physiological Science, 2 Molecular, Cellular, Integrative Physiology Program, 3 Department of Neurology and Semel Institute and Department of…”
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Song practice promotes acute vocal variability at a key stage of sensorimotor learning
Published in PloS one (06-01-2010)“…Trial by trial variability during motor learning is a feature encoded by the basal ganglia of both humans and songbirds, and is important for reinforcement of…”
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Singing Mice, Songbirds, and More: Models for FOXP2 Function and Dysfunction in Human Speech and Language
Published in The Journal of neuroscience (11-10-2006)“…In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis of an inherited speech and language disorder suffered by…”
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Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds
Published in Journal of comparative neurology (1911) (01-06-2010)“…Multiple studies, involving distinct clinical populations, implicate contactin associated protein‐like 2 (CNTNAP2) in aspects of language development and…”
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Social regulation of gonadotropin-releasing hormone
Published in Journal of experimental biology (01-09-2002)“…Behavioral interactions among social animals can regulate both reproductive behavior and fertility. A prime example of socially regulated reproduction occurs…”
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Recent Advances in the Genetics of Vocal Learning
Published in Comparative cognition & behavior reviews (2014)“…Language is a complex communicative behavior unique to humans, and its genetic basis is poorly understood. Genes associated with human speech and language…”
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Birdsong as a window into language origins and evolutionary neuroscience
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (06-01-2020)“…Humans and songbirds share the key trait of vocal learning, manifested in speech and song, respectively. Striking analogies between these behaviours include…”
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Behavior-linked FoxP2 regulation enables zebra finch vocal learning
Published in The Journal of neuroscience (18-02-2015)“…Mutations in the FOXP2 transcription factor cause an inherited speech and language disorder, but how FoxP2 contributes to learning of these vocal communication…”
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Basal ganglia: Bursting with song
Published in Current biology (21-06-2021)“…The songs of mature zebra finches are notoriously repetitious, or ‘crystallized’. Despite this stability, new work reveals that chronic pharmacologically…”
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