Search Results - "White, Phillip J"

Branched-chain amino acids in disease by White, Phillip J, Newgard, Christopher B

“…Are BCAAs a biomarker, causal agent, or both in cardiometabolic disease? Human proteins are assembled from 20 amino acids, nine of which are considered…”
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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression by Ericksen, Russell E., Lim, Siew Lan, McDonnell, Eoin, Shuen, Wai Ho, Vadiveloo, Maya, White, Phillip J., Ding, Zhaobing, Kwok, Royston, Lee, Philip, Radda, George K., Toh, Han Chong, Hirschey, Matthew D., Han, Weiping

“…Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a…”
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BCAA catabolism in brown fat controls energy homeostasis through SLC25A44 by Yoneshiro, Takeshi, Wang, Qiang, Tajima, Kazuki, Matsushita, Mami, Maki, Hiroko, Igarashi, Kaori, Dai, Zhipeng, White, Phillip J., McGarrah, Robert W., Ilkayeva, Olga R., Deleye, Yann, Oguri, Yasuo, Kuroda, Mito, Ikeda, Kenji, Li, Huixia, Ueno, Ayano, Ohishi, Maki, Ishikawa, Takamasa, Kim, Kyeongkyu, Chen, Yong, Sponton, Carlos Henrique, Pradhan, Rachana N., Majd, Homa, Greiner, Vanille Juliette, Yoneshiro, Momoko, Brown, Zachary, Chondronikola, Maria, Takahashi, Haruya, Goto, Tsuyoshi, Kawada, Teruo, Sidossis, Labros, Szoka, Francis C., McManus, Michael T., Saito, Masayuki, Soga, Tomoyoshi, Kajimura, Shingo

“…Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased…”
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Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street by White, Phillip J., McGarrah, Robert W., Herman, Mark A., Bain, James R., Shah, Svati H., Newgard, Christopher B.

“…A strong association of obesity and insulin resistance with increased circulating levels of branched-chain and aromatic amino acids and decreased glycine…”
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase by White, Phillip J., McGarrah, Robert W., Grimsrud, Paul A., Tso, Shih-Chia, Yang, Wen-Hsuan, Haldeman, Jonathan M., Grenier-Larouche, Thomas, An, Jie, Lapworth, Amanda L., Astapova, Inna, Hannou, Sarah A., George, Tabitha, Arlotto, Michelle, Olson, Lyra B., Lai, Michelle, Zhang, Guo-Fang, Ilkayeva, Olga, Herman, Mark A., Wynn, R. Max, Chuang, David T., Newgard, Christopher B.

“…Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood…”
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Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats by McGarrah, Robert W, Zhang, Guo-Fang, Christopher, Bridgette A, Deleye, Yann, Walejko, Jacquelyn M, Page, Stephani, Ilkayeva, Olga, White, Phillip J, Newgard, Christopher B

“…Elevations in circulating levels of branched-chain amino acids (BCAAs) are associated with a variety of cardiometabolic diseases and conditions. Restriction of…”
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Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism by Shin, Andrew C., Fasshauer, Martin, Filatova, Nika, Grundell, Linus A., Zielinski, Elizabeth, Zhou, Jian-Ying, Scherer, Thomas, Lindtner, Claudia, White, Phillip J., Lapworth, Amanda L., Ilkayeva, Olga, Knippschild, Uwe, Wolf, Anna M., Scheja, Ludger, Grove, Kevin L., Smith, Richard D., Qian, Wei-Jun, Lynch, Christopher J., Newgard, Christopher B., Buettner, Christoph

“…Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes. Here we show in rats…”
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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart by Walejko, Jacquelyn M., Christopher, Bridgette A., Crown, Scott B., Zhang, Guo-Fang, Pickar-Oliver, Adrian, Yoneshiro, Takeshi, Foster, Matthew W., Page, Stephani, van Vliet, Stephan, Ilkayeva, Olga, Muehlbauer, Michael J., Carson, Matthew W., Brozinick, Joseph T., Hammond, Craig D., Gimeno, Ruth E., Moseley, M. Arthur, Kajimura, Shingo, Gersbach, Charles A., Newgard, Christopher B., White, Phillip J., McGarrah, Robert W.

“…Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major…”
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Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice by Choi, Béatrice S.-Y., Daniel, Noëmie, Houde, Vanessa P., Ouellette, Adia, Marcotte, Bruno, Varin, Thibault V., Vors, Cécile, Feutry, Perrine, Ilkayeva, Olga, Ståhlman, Marcus, St-Pierre, Philippe, Bäckhed, Fredrik, Tremblay, Angelo, White, Phillip J., Marette, André

“…Animal models of human diseases are classically fed purified diets that contain casein as the unique protein source. We show that provision of a mixed protein…”
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Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice by WHITE, Phillip J, ARITA, Makoto, TAGUCHI, Ryo, KANG, Jing X, MARETTE, André

“…The catabasis of inflammation is an active process directed by n-3 derived pro-resolving lipid mediators. We aimed to determine whether high-fat (HF)…”
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Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis by White, Phillip J, St-Pierre, Philippe, Charbonneau, Alexandre, Mitchell, Patricia L, St-Amand, Emmanuelle, Marcotte, Bruno, Marette, André

“…Lower levels of ω–3 fatty acid–derived resolution mediators have been linked to insulin resistance in obese mice. André Marette and his colleagues now show…”
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Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export by White, Phillip J, Lapworth, Amanda L, An, Jie, Wang, Liping, McGarrah, Robert W, Stevens, Robert D, Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J, Bain, James R, Trimmer, Jeff K, Brosnan, M. Julia, Rolph, Timothy P, Newgard, Christopher B

“…Abstract Objective A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident…”
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Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans by Glynn, Erin L., Piner, Lucy W., Huffman, Kim M., Slentz, Cris A., Elliot-Penry, Lorraine, AbouAssi, Hiba, White, Phillip J., Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga R., Stevens, Robert D., Porter Starr, Kathryn N., Bales, Connie W., Volpi, Elena, Brosnan, M. Julia, Trimmer, Jeff K., Rolph, Timothy P., Newgard, Christopher B., Kraus, William E.

“…Aims/hypotheses Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study…”
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Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion by White, Phillip J., Lapworth, Amanda L., McGarrah, Robert W., Kwee, Lydia Coulter, Crown, Scott B., Ilkayeva, Olga, An, Jie, Carson, Matthew W., Christopher, Bridgette A., Ball, James R., Davies, Michael N., Kjalarsdottir, Lilja, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Stevens, Robert D., Koves, Timothy R., Muoio, Deborah M., Brozinick, Joseph T., Gimeno, Ruth E., Brosnan, M. Julia, Rolph, Timothy P., Kraus, William E., Shah, Svati H., Newgard, Christopher B.

“…Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain…”
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Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia by Chandra, Rashmi, Aryal, Dipendra K, Douros, Jonathan D, Shahid, Rafiq, Davis, Supriya J, Campbell, Jonathan E, Ilkayeya, Olga, White, Phillip J, Rodriguez, Ramona, Newgard, Christopher B, Wetsel, William C, Liddle, Rodger A

“…Objective Immunoglobulin-like Domain-Containing Receptor 1 (ILDR1) is expressed on nutrient sensing cholecystokinin-positive enteroendocrine cells of the…”
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Potential role of omega‐3‐derived resolution mediators in metabolic inflammation by White, Phillip J, Marette, André

“…In its most reduced form, metabolic inflammation can be best described as a maladaptive process that involves an integrated innate and acquired immune response…”
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Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever by Yoneshiro, Takeshi, Kataoka, Naoya, Walejko, Jacquelyn M, Ikeda, Kenji, Brown, Zachary, Yoneshiro, Momoko, Crown, Scott B, Osawa, Tsuyoshi, Sakai, Juro, McGarrah, Robert W, White, Phillip J, Nakamura, Kazuhiro, Kajimura, Shingo

“…Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAAs) are…”
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Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat–fed rats by Pilon, Geneviève, Ruzzin, Jérôme, Rioux, Laurie-Eve, Lavigne, Charles, White, Phillip J, Frøyland, Livar, Jacques, Hélène, Bryl, Piotr, Beaulieu, Lucie, Marette, André

“…Abstract Mounting evidence suggests that the benefits of fish consumption are not limited to the well-appreciated effects of omega-3 fatty acids. We previously…”
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Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle by Pilon, Geneviève, Charbonneau, Alexandre, White, Phillip J, Dallaire, Patrice, Perreault, Mylène, Kapur, Sonia, Marette, André

“…It is believed that the endotoxin lipopolysaccharide (LPS) is implicated in the metabolic perturbations associated with both sepsis and obesity (metabolic…”
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Branched‐chain α‐keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity by Gumus Balikcioglu, Pinar, Jachthuber Trub, Catherine, Balikcioglu, Metin, Ilkayeva, Olga, White, Phillip J., Muehlbauer, Michael, Bain, James R., Armstrong, Sarah, Freemark, Michael

“…Objectives Insulin resistance (IR) in adolescents with obesity is associated with a sex‐dependent metabolic ‘signature’ comprising the branched‐chain amino…”
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