Search Results - "White, Madeleine P"

Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy by Weth, Freya R., Hoggarth, Georgia B., Weth, Anya F., Paterson, Erin, White, Madeleine P. J., Tan, Swee T., Peng, Lifeng, Gray, Clint

“…High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and development have led to a growing interest in repurposing “old” drugs…”
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The tumour microenvironment, treatment resistance and recurrence in glioblastoma by White, Jasmine, White, Madeleine P J, Wickremesekera, Agadha, Peng, Lifeng, Gray, Clint

“…The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an incurable…”
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Recent advances in understanding the molecular basis of infantile haemangioma development by Mitra, Raka, Fitzsimons, Helen L, Hale, Tracy, Tan, Swee T, Gray, Clint, White, Madeleine P J

“…Infantile haemangioma (IH) - the most common vascular tumour of infancy - is comprised of diverse cell types, including endothelial cells, pericytes,…”
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Integrity of RNA in long-term-stored cervical liquid-based cytology samples: implications for biomarker research by J White, Madeleine P, Stevenson, Andrew, Elasifer, Hana, Davies, Chris, Nomikou, Kyriaki, Cuschieri, Kate, Graham, Sheila V

“…Biobanks of cervical screening (LBC) samples annotated with disease status are an invaluable resource to support the development of tools for the risk…”
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The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF) by Varyani, Fumi, Löser, Stephan, Filbey, Kara J., Harcus, Yvonne, Drurey, Claire, Poveda, Marta Campillo, Rasid, Orhan, White, Madeleine P. J., Smyth, Danielle J., Gerbe, François, Jay, Philippe, Maizels, Rick M.

“…Macrophage migration inhibitory factor (MIF) is a key innate immune mediator with chemokine- and cytokine-like properties in the inflammatory pathway. While…”
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A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells by Johnston, Chris J. C., Smyth, Danielle J., Kodali, Ravindra B., White, Madeleine P. J., Harcus, Yvonne, Filbey, Kara J., Hewitson, James P., Hinck, Cynthia S., Ivens, Alasdair, Kemter, Andrea M., Kildemoes, Anna O., Le Bihan, Thierry, Soares, Dinesh C., Anderton, Stephen M., Brenn, Thomas, Wigmore, Stephen J., Woodcock, Hannah V., Chambers, Rachel C., Hinck, Andrew P., McSorley, Henry J., Maizels, Rick M.

“…Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells…”
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The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner by White, Madeleine P J, Johnston, Chris J C, Grainger, John R, Konkel, Joanne E, O'Connor, Richard A, Anderton, Stephen M, Maizels, Rick M

“…Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus…”
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The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function by Oftedal, Bergithe E., Maio, Stefano, Handel, Adam E., White, Madeleine P. J., Howie, Duncan, Davis, Simon, Prevot, Nicolas, Rota, Ioanna A., Deadman, Mary E., Kessler, Benedikt M., Fischer, Roman, Trede, Nikolaus S., Sezgin, Erdinc, Maizels, Rick M., Holländer, Georg A.

“…T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In…”
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Regulatory T‐cells in helminth infection: induction, function and therapeutic potential by White, Madeleine P. J., McManus, Caitlin M., Maizels, Rick M.

“…Summary Helminth parasites infect an alarmingly large proportion of the world's population, primarily within tropical regions, and their ability to…”
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Innate IFN-γ ameliorates experimental autoimmune encephalomyelitis and promotes myeloid expansion and PDL-1 expression by White, Madeleine P. J., Webster, Gill, Leonard, Faith, La Flamme, Anne Camille

“…The innate immune system plays a central role in the immune-mediated pathology of multiple sclerosis, and is a therapeutic target for progressive disease…”
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Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model by Smyth, Danielle J., Ren, Bijie, White, Madeleine P.J., McManus, Caitlin, Webster, Holly, Shek, Vivien, Evans, Caroline, Pandhal, Jagroop, Fields, Francis, Maizels, Rick M., Mayfield, Stephen

“…Inflammatory bowel disease (IBD) is a set of immunological disorders which can generate chronic pain and fatigue associated with the inflammatory symptoms. The…”
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The parasite cytokine mimic Hp‐TGM potently replicates the regulatory effects of TGF‐β on murine CD4+ T cells by White, Madeleine P J, Smyth, Danielle J, Cook, Laura, Ziegler, Steven F, Levings, Megan K, Maizels, Rick M

“…Transforming growth factor‐beta (TGF‐β) family proteins mediate many vital biological functions in growth, development and regulation of the immune system…”
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TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus by Smyth, Danielle J., Harcus, Yvonne, White, Madeleine P.J., Gregory, William F., Nahler, Janina, Stephens, Ian, Toke-Bjolgerud, Edward, Hewitson, James P., Ivens, Alasdair, McSorley, Henry J., Maizels, Rick M.

“…[Display omitted] •A new family of parasite-specific TGF-β mimics was identified.•Members of the new family are secreted by larval and adult life cycle…”
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CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic by van Dinther, Maarten, Cunningham, Kyle T, Singh, Shashi Prakash, White, Madeleine P J, Campion, Tiffany, Ciancia, Claire, van Veelen, Peter A, de Ru, Arnoud H, González-Prieto, Román, Mukundan, Ananya, Byeon, Chang-Hyeock, Staggers, Sophia R, Hinck, Cynthia S, Hinck, Andrew P, Dijke, Peter Ten, Maizels, Rick M

“…Long-lived parasites evade host immunity through highly evolved molecular strategies. The murine intestinal helminth, , down-modulates the host immune system…”
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Urinary excretion of calcium and phosphate in preterm infants by Aladangady, Narendra, Coen, Pietro G, White, Madeleine P, Rae, Margaret D, Beattie, T James

“…The aims of this study were to determine reference ranges for the urinary calcium (UCa/Cr) and phosphate (UPO(4)/Cr) creatinine ratios and to study factors…”
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Induction of stable human FOXP3+ Tregs by a parasite‐derived TGF‐β mimic by Cook, Laura, Reid, Kyle T, Häkkinen, Elmeri, Bie, Brett, Tanaka, Shigeru, Smyth, Danielle J, White, Madeleine PJ, Wong, May Q, Huang, Qing, Gillies, Jana K, Ziegler, Steven F., Maizels, Rick M, Levings, Megan K

“…Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defects of which are linked to the development of chronic…”
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Urinary citrate in preterm and term babies by White, Madeleine P., Aladangady, Narendra, Rolton, Hilary A., McColl, John H., Beattie, Jim

“…(1) To determine a normal range for urinary citrate for term babies. (2) To compare urinary citrate measured in ex preterm babies at term with this normal…”
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Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, Hp -TGM by Smyth, Danielle J, White, Madeleine P J, Johnston, Chris J C, Donachie, Anne-Marie, Campillo Poveda, Marta, McSorley, Henry J, Maizels, Rick M

“…In animal models of inflammatory colitis, pathology can be ameliorated by several intestinal helminth parasites, including the mouse nematode . To identify…”
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Nephrocalcinosis in preterm babies. Commentary on Rockwell et al.: preliminary observations of urinary calcium and osteopontin excretion in premature infants, term infants and adults (Neonatology 2008;93:241-245) by White, Madeleine P

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Respiratory syncytial virus infection in special care nursery by White, M P, Mackie, P L

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