Search Results - "White, Katharine A."

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance by White, Katharine A, Grillo-Hill, Bree K, Barber, Diane L

“…Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH ) and a decreased extracellular pH (pH ) compared…”
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An Optogenetic Tool to Raise Intracellular pH in Single Cells and Drive Localized Membrane Dynamics by Donahue, Caitlin E. T, Siroky, Michael D, White, Katharine A

“…Intracellular pH (pHi) dynamics are critical for regulating normal cell physiology. For example, transient increases in pHi (7.2–7.6) regulate cell behaviors…”
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fluorophore ligase for site-specific protein labeling inside living cells by Uttamapinant, Chayasith, White, Katharine A, Baruah, Hemanta, Thompson, Samuel, Fernández-Suárez, Marta, Puthenveetil, Sujiet, Ting, Alice Y

“…Biological microscopy would benefit from smaller alternatives to green fluorescent protein for imaging specific proteins in living cells. Here we introduce…”
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Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective by Liu, Yi, White, Katharine A., Barber, Diane L.

“…The International Society of Cancer Metabolism (ISCaM) meeting on Cancer Metabolic Rewiring, held in Braga Portugal in October 2019, provided an outstanding…”
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Prominent features of the amino acid mutation landscape in cancer by Szpiech, Zachary A, Strauli, Nicolas B, White, Katharine A, Ruiz, Diego Garrido, Jacobson, Matthew P, Barber, Diane L, Hernandez, Ryan D

“…Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver mutations, and genetic signatures. Accordingly, each of…”
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Site-specific protein labeling using PRIME and chelation-assisted click chemistry by Uttamapinant, Chayasith, Sanchez, Mateo I, Liu, Daniel S, Yao, Jennifer Z, White, Katharine A, Grecian, Scott, Clark, Scott, Gee, Kyle R, Ting, Alice Y

“…This protocol describes an efficient method to site-specifically label cell-surface or purified proteins with chemical probes in two steps: probe incorporation…”
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Yeast Display Evolution of a Kinetically Efficient 13-Amino Acid Substrate for Lipoic Acid Ligase by Puthenveetil, Sujiet, Liu, Daniel S, White, Katharine A, Thompson, Samuel, Ting, Alice Y

“…Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins…”
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Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation by Liu, Daniel S, Loh, Ken H, Lam, Stephanie S, White, Katharine A, Ting, Alice Y

“…Neurexin and neuroligin are transmembrane adhesion proteins that play an important role in organizing the neuronal synaptic cleft. Our lab previously reported…”
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A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1 by Vercoulen, Yvonne, Kondo, Yasushi, Iwig, Jeffrey S, Janssen, Axel B, White, Katharine A, Amini, Mojtaba, Barber, Diane L, Kuriyan, John, Roose, Jeroen P

“…RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or…”
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Charactering ionizable residue networks at SH2 interfaces in pH-sensitive proteins by Van Dyck, Papa Kobina, White, Katharine A.

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Oncogenic β-catenin mutations evade pH-regulated degradation by Grillo-Hill, Bree K., White, Katharine A.

“…β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi),…”
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Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition by Spear, Julia S, White, Katharine A

“…Transient changes in intracellular pH (pHi) regulate normal cell behaviors, but roles for spatiotemporal pHi dynamics in single-cell behaviors remain unclear…”
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Selecting for pH sensitive flourescent proteins with library screening methods by Wagner, Jacob E., White, Katharine A., Knuth, Casey

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Intracellular pH dynamics and charge-changing somatic mutations in cancer by White, Katharine A., Kisor, Kyle, Barber, Diane L.

“…An unresolved question critical for understanding cancer is how recurring somatic mutations are retained and how selective pressures drive retention. Increased…”
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Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells by Romero-Moreno, Ricardo, Czowski, Brandon J., Harris, Lindsey, Kuehn, Jessamine F., White, Katharine A.

“…Intracellular pH (pHi) dynamics regulate normal cell function, and dysregulated pHi dynamics is an emerging hallmark of cancer (constitutively increased pHi)…”
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Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2‑Hydroxyglutarate by Sesanto, Rae, Kuehn, Jessamine F, Barber, Diane L, White, Katharine A

“…Isocitrate dehydrogenase 1 (IDH1) is a key metabolic enzyme for maintaining cytosolic levels of α-ketoglutarate (AKG) and preserving the redox environment of…”
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β-Catenin is a pH sensor with decreased stability at higher intracellular pH by White, Katharine A, Grillo-Hill, Bree K, Esquivel, Mario, Peralta, Jobelle, Bui, Vivian N, Chire, Ismahan, Barber, Diane L

“…β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which…”
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Charting a New Frontier Integrating Mathematical Modeling in Complex Biological Systems from Molecules to Ecosystems by White, Katharine A, McEntire, Kira D, Buan, Nicole R, Robinson, Lecia, Barbar, Elisar

“…Abstract Advances in quantitative biology data collection and analysis across scales (molecular, cellular, organismal, and ecological) have transformed how we…”
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Cancer and pH Dynamics: Transcriptional Regulation, Proteostasis, and the Need for New Molecular Tools by Czowski, Brandon J., Romero-Moreno, Ricardo, Trull, Keelan J., White, Katharine A.

“…An emerging hallmark of cancer cells is dysregulated pH dynamics. Recent work has suggested that dysregulated intracellular pH (pHi) dynamics enable diverse…”
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An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity by Luna, Lucas A, Lesecq, Zachary, White, Katharine A, Hoang, An, Scott, David A, Zagnitko, Olga, Bobkov, Andrey A, Barber, Diane L, Schiffer, Jamie M, Isom, Daniel G, Sohl, Christal D

“…Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate to α-ketoglutarate (αKG) to provide critical cytosolic…”
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