Search Results - "White, Ian K."

Electric-field-stimulated protein mechanics by Hekstra, Doeke R., White, K. Ian, Socolich, Michael A., Henning, Robert W., Šrajer, Vukica, Ranganathan, Rama

“…The internal mechanics of proteins—the coordinated motions of amino acids and the pattern of forces constraining these motions—connects protein structure to…”
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Structural principles of SNARE complex recognition by the AAA+ protein NSF by White, K Ian, Zhao, Minglei, Choi, Ucheor B, Pfuetzner, Richard A, Brunger, Axel T

“…The recycling of SNARE proteins following complex formation and membrane fusion is an essential process in eukaryotic trafficking. A highly conserved AAA+…”
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NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin by Choi, Ucheor B, Zhao, Minglei, White, K Ian, Pfuetzner, Richard A, Esquivies, Luis, Zhou, Qiangjun, Brunger, Axel T

“…SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule…”
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Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control by Gao, Yan, Khan, Yousuf A., Mo, Weike, White, K. Ian, Perkins, Matthew, Pfuetzner, Richard A., Trapani, Josef G., Brunger, Axel T., Nicolson, Teresa

“…The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced…”
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Calibration of rotation axes for multi‐axis goniometers in macromolecular crystallography by White, K. Ian, Bugris, Valeria, McCarthy, Andrew A., Ravelli, Raimond B. G., Csankó, Krisztián, Cassetta, Alberto, Brockhauser, Sandor

“…The installation of multi‐axis goniometers such as the ESRF/EMBL miniKappa goniometer system has allowed the increased use of sample reorientation in…”
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Predictors of Outcomes and Complications After Microsurgical and Endovascular Treatment of 1300 Intracranial Aneurysms by Acioly, Marcus André, Shaikh, Kashif A., White, Ian K., Ziemba-Davis, Mary, Bohnstedt, Bradley N., Cohen-Gadol, Aaron

“…We performed a rigorous statistical analysis of the complications and outcomes of patients with ruptured or unruptured intracranial aneurysms. Our emphasis was…”
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Origins of Allostery and Evolvability in Proteins: A Case Study by Raman, Arjun S., White, K. Ian, Ranganathan, Rama

“…Proteins display the capacity for adaptation to new functions, a property critical for evolvability. But what structural principles underlie the capacity for…”
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The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines by Khan, Yousuf A, White, K Ian, Brunger, Axel T

“…ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of proteins found throughout all domains of life. The hallmark of this…”
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Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle by Yang, Kailu, Wang, Chuchu, White, K Ian, Pfuetzner, Richard A, Esquivies, Luis, Brunger, Axel T

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies due…”
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Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies by Alten, Baris, Zhou, Qiangjun, Shin, Ok-Ho, Esquivies, Luis, Lin, Pei-Yi, White, K. Ian, Sun, Rong, Chung, Wendy K., Monteggia, Lisa M., Brunger, Axel T., Kavalali, Ege T.

“…SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex, composed of synaptobrevin, syntaxin, and SNAP25, forms the essential…”
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Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor by Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J B, White, K Ian, Pfuetzner, Richard A, Esquivies, Luis, Kirchhausen, Tomas, Brunger, Axel T

“…The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduced a relatively large number of mutations, including three…”
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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein by Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J B, Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J, White, K Ian, Held, Richard G, Subramanian, Subu, Marcus, Kendra, Pfuetzner, Richard A, Esquivies, Luis, Doyle, Catherine A, Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tom, Brunger, Axel T

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available coronavirus disease 2019 vaccines and monoclonal…”
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Drug discovery targeting SARS-CoV-2 membrane fusion by Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J.B., Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J., White, K. Ian, Pfuetzner, Richard, Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tomas, Brunger, Axel T.

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Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing by Wilson, Steven C, White, K Ian, Zhou, Qiangjun, Pfuetzner, Richard A, Choi, Ucheor B, Südhof, Thomas C, Brunger, Axel T

“…Neurexins are presynaptic, cell‐adhesion molecules that specify the functional properties of synapses via interactions with trans‐synaptic ligands. Neurexins…”
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Analysis of long-term (median 10.5 years) outcomes in children presenting with traumatic brain injury and an initial Glasgow Coma Scale score of 3 or 4 by Fulkerson, Daniel H, White, Ian K, Rees, Jacqueline M, Baumanis, Maraya M, Smith, Jodi L, Ackerman, Laurie L, Boaz, Joel C, Luerssen, Thomas G

“…Patients with traumatic brain injury (TBI) with low presenting Glasgow Coma Scale (GCS) scores have very high morbidity and mortality rates. Neurosurgeons may…”
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Transfer of children with isolated linear skull fractures: is it worth the cost? by White, Ian K, Pestereva, Ecaterina, Shaikh, Kashif A, Fulkerson, Daniel H

“…OBJECTIVE Children with skull fractures are often transferred to hospitals with pediatric neurosurgical capabilities. Historical data suggest that a small…”
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Risk of deep venous thrombosis in elective neurosurgical procedures: a prospective, Doppler ultrasound-based study in children 12 years of age or younger by Scherer, Andrea G, White, Ian K, Shaikh, Kashif A, Smith, Jodi L, Ackerman, Laurie L, Fulkerson, Daniel H

“…OBJECTIVE The risk of venous thromboembolism (VTE) from deep venous thrombosis (DVT) is significant in neurosurgical patients. VTE is considered a leading…”
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Rapidly enlarging low-grade fibromyxoid sarcoma with intracranial extension in a 5-year-old girl: case report by White, Ian K, Scherer, Andrea G, Baumanis, Maraya M, Abdulkader, Marwah, Fulkerson, Daniel H

“…Low-grade fibromyxoid sarcoma (LGFMS) is a rare mesenchymal tumor that is characterized by a benign histology but potentially aggressive clinical behavior,…”
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The Use of Bone Morphogenetic Protein in the Intervertebral Disk Space in Minimally Invasive Transforaminal Lumbar Interbody Fusion: 10-year Experience in 688 Patients by White, Ian K, Tuohy, Megan, Archer, Jacob, Schroeder, Gregory D, Vaccaro, Alexander R, Mobasser, Jean-Pierre

“…Retrospective Cohort. The objective of this study was to characterize one surgeon's experience over a 10-year period using rhBMP-2 in the disk space for…”
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Analysis of the potential risk of central intravenous lines and/or total parenteral nutrition with ventriculoatrial shunts by White, Ian K., Shaikh, Kashif A., Nyarenchi, Obed M., Kundu, Madan G., Boaz, Joel C., Fulkerson, Daniel H.

“…Object The distal catheter of a ventriculoatrial (VA) cerebrospinal fluid shunt is potentially exposed to bacterial seeding from a subclavian central line. The…”
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