Infrared Fluorescence-guided Surgery for Tumor and Metastatic Lymph Node Detection in Head and Neck Cancer

In patients with head and neck cancer (HNC), surgical removal of cancerous tissue presents the best overall survival rate. However, failure to obtain negative margins during resection has remained a steady concern over the past 3 decades. The need for improved tumor removal and margin assessment pre...

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Bibliographic Details
Published in:	Radiology. Imaging cancer Vol. 6; no. 4; p. e230178
Main Authors:	White, Haley W, Naveed, Abdullah Bin, Campbell, Benjamin R, Lee, Yu-Jin, Baik, Fred M, Topf, Michael, Rosenthal, Eben L, Hom, Marisa E
Format:	Journal Article
Language:	English
Published:	United States Radiological Society of North America 01-07-2024
Subjects:	Fluorescence Fluorescent Dyes Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - surgery Humans Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - diagnostic imaging Optical Imaging - methods Review Spectroscopy, Near-Infrared - methods Surgery, Computer-Assisted - methods Fluorescence Molecular Imaging–Cancer
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Summary:	In patients with head and neck cancer (HNC), surgical removal of cancerous tissue presents the best overall survival rate. However, failure to obtain negative margins during resection has remained a steady concern over the past 3 decades. The need for improved tumor removal and margin assessment presents an ongoing concern for the field. While near-infrared agents have long been used in imaging, investigation of these agents for use in HNC imaging has dramatically expanded in the past decade. Targeted tracers for use in primary and metastatic lymph node detection are of particular interest, with panitumumab-IRDye800 as a major candidate in current studies. This review aims to provide an overview of intraoperative near-infrared fluorescence-guided surgery techniques used in the clinical detection of malignant tissue and sentinel lymph nodes in HNC, highlighting current applications, limitations, and future directions for use of this technology within the field. Molecular Imaging-Cancer, Fluorescence © RSNA, 2024.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2638-616X 2638-616X
DOI:	10.1148/rycan.230178