Search Results - "White, Ed"

Mechanical modulation of cardiac microtubules by White, Ed

“…Microtubules are a major component of the cardiac myocyte cytoskeleton. Interventions that alter it may influence cardiac mechanical and electrical activity by…”
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The Frank-Starling mechanism in vertebrate cardiac myocytes by Shiels, Holly A, White, Ed

“…The Frank-Starling law of the heart applies to all classes of vertebrates. It describes how stretch of cardiac muscle, up to an optimum length, increases…”
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Caveolae Act as Membrane Reserves Which Limit Mechanosensitive ICl,swell Channel Activation during Swelling in the Rat Ventricular Myocyte by Kozera, Lukasz, White, Ed, Calaghan, Sarah

“…Background Many ion channels are preferentially located in caveolae where compartmentalisation/scaffolding with signal transduction components regulates their…”
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Mechanosensitive channels: therapeutic targets in the myocardium? by White, Ed

“…Mechanosensitivity is a property common to many cell types. Because channels gated by mechanical stimuli (mechanosensitive channels, MSCs) are implicated in…”
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Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts by Hurley, Miriam, Walton, Richard, Vigmond, Edward J, Haïssaguerre, Michel, Bernus, Olivier, White, Ed

“…Purkinje fibres (PFs) play an important role in some ventricular arrhythmias and acute ventricular stretch can evoke mechanically-induced arrhythmias. We…”
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Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System by Fowler, Ewan D, Hauton, David, Boyle, John, Egginton, Stuart, Steele, Derek S, White, Ed

“…Pulmonary arterial hypertension (PAH) results in hypertrophic remodeling of the right ventricle (RV) to overcome increased pulmonary pressure. This increases…”
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Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease by Hurley, Miriam E, White, Ed, Sheard, Thomas M D, Steele, Derek, Jayasinghe, Izzy

“…Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the fastest types of cytoplasmic second messenger signalling in…”
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Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI by Gilbert, Stephen H, Benoist, David, Benson, Alan P, White, Ed, Tanner, Steven F, Holden, Arun V, Dobrzynski, Halina, Bernus, Olivier, Radjenovic, Aleksandra

“…It has been shown by histology that cardiac myocytes are organized into laminae and this structure is important in function, both influencing the spread of…”
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Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats by Hardy, Matthew E L, Pervolaraki, Eleftheria, Bernus, Olivier, White, Ed

“…We investigated the steepened dynamic action potential duration (APD) restitution of rats with pulmonary artery hypertension (PAH) and right ventricular (RV)…”
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Endocardial role in arrhythmias induced by acute ventricular stretch and the involvement of Purkinje fibres, in isolated rat hearts by Hurley, Miriam, Kaur, Sarbjot, Walton, Richard, Power, Amelia, Haïssaguerre, Michel, Bernus, Olivier, Ward, Marie-Louise, White, Ed

“…Purkinje fibres (PFs) play an important role in some ventricular arrhythmias and acute ventricular stretch can evoke mechanically-induced arrhythmias. We…”
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A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development by Diggle, Christine P, Martinez-Garay, Isabel, Molnar, Zoltan, Brinkworth, Martin H, White, Ed, Fowler, Ewan, Hughes, Ruth, Hayward, Bruce E, Carr, Ian M, Watson, Christopher M, Crinnion, Laura, Asipu, Aruna, Woodman, Ben, Coletta, P Louise, Markham, Alexander F, Dear, T Neil, Bonthron, David T, Peckham, Michelle, Morrison, Ewan E, Sheridan, Eamonn

“…Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification…”
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Activation of Na+–H+ exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart by Calaghan, Sarah, White, Ed

“…We present the first direct comparison of the major candidates proposed to underlie the slow phase of the force increase seen following myocardial stretch: (i)…”
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Canonical Predicaments by White, Ed, Faherty, Duncan

“…The participation of thirteen teachers around the country, five of whom we asked to write more sustained reflections for this forum, reminded us yet again of…”
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Excerpts from Sincerity; A Novel in a Series of Original Letters, by Susanna Rowson by White, Ed, Faherty, Duncan

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Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension by Temple, Ian P, Logantha, Sunil Jit R.J, Absi, Mais, Zhang, Yu, Pervolaraki, Eleftheria, Yanni, Joseph, Atkinson, Andrew, Petkova, Maria, Quigley, Gillian M, Castro, Simon, Drinkhill, Mark, Schneider, Heiko, Monfredi, Oliver, Cartwright, Elizabeth, Zi, Min, Yamanushi, Tomoko T, Mahadevan, Vaikom S, Gurney, Alison M, White, Ed, Zhang, Henggui, Hart, George, Boyett, Mark R, Dobrzynski, Halina

“…BACKGROUND—Heart block is associated with pulmonary hypertension, and the aim of the study was to test the hypothesis that the heart block is the result of a…”
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Increased mechanically-induced ectopy in the hypertrophied heart by Kim, Do Yeong, White, Ed, Saint, David A.

“…Left ventricular hypertrophy (LVH) predisposes patients to arrhythmias, but the mechanism of these arrhythmias is unclear. Here we show that hearts from…”
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Regional skeletal muscle remodeling and mitochondrial dysfunction in right ventricular heart failure by Wüst, Rob C I, Myers, David S, Stones, Rachel, Benoist, David, Robinson, Philip A, Boyle, John P, Peers, Chris, White, Ed, Rossiter, Harry B

“…Exercise intolerance is a cardinal symptom of right ventricular heart failure (RV HF) and skeletal muscle adaptations play a role in this limitation. We…”
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The air-breathing Alaska blackfish (Dallia pectoralis) remodels ventricular Ca2+ cycling with chronic hypoxic submergence to maintain ventricular contractility by Shiels, Holly A., White, Ed, Couturier, Christine S., Hall, Diarmid, Royal, Shannon, Galli, Gina L.J., Stecyk, Jonathan A.W.

“…The Alaska blackfish (Dallia pectoralis) is a facultative air-breather endemic to northern latitudes where it remains active in winter under ice cover in cold…”
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Tapering antidepressants: why do tens of thousands turn to Facebook groups for support? by White, Ed

“…White discusses tapering the use of antidpressants. AD withdrawal has a long history in scientific literature, with many papers describing its occurrence and…”
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Streptomycin and intracellular calcium modulate the response of single guinea-pig ventricular myocytes to axial stretch by Belus, Alexandra, White, Ed

“…We tested the hypothesis that both stretch-activated channels (SACs) and intracellular calcium ([Ca 2+ ] i ) are important in the electrical response of single…”
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