Search Results - "White, E Lucile"

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations by Mutyam, Venkateshwar, Du, Ming, Xue, Xiaojiao, Keeling, Kim M, White, E Lucile, Bostwick, J Robert, Rasmussen, Lynn, Liu, Bo, Mazur, Marina, Hong, Jeong S, Falk Libby, Emily, Liang, Feng, Shang, Haibo, Mense, Martin, Suto, Mark J, Bedwell, David M, Rowe, Steven M

“…Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Several agents are known…”
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Ultrasound tightening of facial and neck skin: A rater-blinded prospective cohort study by Alam, Murad, MD, MSCI, White, Lucile E., MD, Martin, Nicolle, MD, Witherspoon, Joslyn, MD, MPH, Yoo, Simon, MD, West, Dennis P., PhD

“…Background Nonablative skin tightening technologies offer the prospect of reduction of wrinkles and skin sagging with minimal downtime, discomfort, and risk of…”
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Combining Computational Methods for Hit to Lead Optimization in Mycobacterium Tuberculosis Drug Discovery by Ekins, Sean, Freundlich, Joel S., Hobrath, Judith V., Lucile White, E., Reynolds, Robert C.

“…ABSTRACT Purpose Tuberculosis treatments need to be shorter and overcome drug resistance. Our previous large scale phenotypic high-throughput screening against…”
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Discovery of a novel inhibitor of kinesin-like protein KIFC1 by Zhang, Wei, Zhai, Ling, Wang, Yimin, Boohaker, Rebecca J, Lu, Wenyan, Gupta, Vandana V, Padmalayam, Indira, Bostwick, Robert J, White, E Lucile, Ross, Larry J, Maddry, Joseph, Ananthan, Subramaniam, Augelli-Szafran, Corinne E, Suto, Mark J, Xu, Bo, Li, Rongbao, Li, Yonghe

“…Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of…”
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Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach by Xiao, Shiqi, Guo, Haidan, Weiner, Warren S, Maddox, Clinton, Mao, Chunhong, Gunosewoyo, Hendra, Pelly, Shaaretha, White, E Lucile, Rasmussen, Lynn, Schoenen, Frank J, Aubé, Jeffrey, Bishai, William R, Lun, Shichun

“…The suboptimal effectiveness of β-lactam antibiotics against has hindered the utility of this compound class for tuberculosis treatment. However, the results…”
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High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv by Ananthan, Subramaniam, Faaleolea, Ellen R, Goldman, Robert C, Hobrath, Judith V, Kwong, Cecil D, Laughon, Barbara E, Maddry, Joseph A, Mehta, Alka, Rasmussen, Lynn, Reynolds, Robert C, Secrist, John A, Shindo, Nice, Showe, Dustin N, Sosa, Melinda I, Suling, William J, White, E. Lucile

“…Summary There is an urgent need for the discovery and development of new antitubercular agents that target new biochemical pathways and treat drug resistant…”
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A High-Throughput Screening Assay for Inhibitors of Bacterial Motility Identifies a Novel Inhibitor of the Na+-Driven Flagellar Motor and Virulence Gene Expression in Vibrio cholerae by RASMUSSEN, Lynn, LUCILE WHITE, E, PATHAK, Ashish, AYALA, Julio C, HONGXIA WANG, WU, Jian-He, BENITEZ, Jorge A, SILVA, Anisia J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1 by Pery, Erez, Sheehy, Ann, Miranda Nebane, N, Misra, Vikas, Mankowski, Marie K, Rasmussen, Lynn, Lucile White, E, Ptak, Roger G, Gabuzda, Dana

“…Abstract APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA; deamination-independent…”
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Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics by Chung, W Joon, Goeckeler-Fried, Jennifer L, Havasi, Viktoria, Chiang, Annette, Rowe, Steven M, Plyler, Zackery E, Hong, Jeong S, Mazur, Marina, Piazza, Gary A, Keeton, Adam B, White, E Lucile, Rasmussen, Lynn, Weissman, Allan M, Denny, R Aldrin, Brodsky, Jeffrey L, Sorscher, Eric J

“…Small molecules that correct the folding defects and enhance surface localization of the F508del mutation in the Cystic Fibrosis Transmembrane conductance…”
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High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv by Reynolds, Robert C, Ananthan, Subramaniam, Faaleolea, Ellen, Hobrath, Judith V, Kwong, Cecil D, Maddox, Clinton, Rasmussen, Lynn, Sosa, Melinda I, Thammasuvimol, Elizabeth, White, E. Lucile, Zhang, Wei, Secrist, John A

“…Summary Kinase targets are being pursued in a variety of diseases beyond cancer, including immune and metabolic as well as viral, parasitic, fungal and…”
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Antituberculosis activity of the molecular libraries screening center network library by Maddry, Joseph A, Ananthan, Subramaniam, Goldman, Robert C, Hobrath, Judith V, Kwong, Cecil D, Maddox, Clinton, Rasmussen, Lynn, Reynolds, Robert C, Secrist, John A, Sosa, Melinda I, White, E. Lucile, Zhang, Wei

“…Summary There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant…”
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Qualification of the Hemagglutination Inhibition Assay in Support of Pandemic Influenza Vaccine Licensure by Noah, Diana L, Hill, Heather, Hines, David, White, E Lucile, Wolff, Mark C

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors by Mathew, Bini, Srivastava, Shefali, Ross, Larry J., Suling, William J., White, E. Lucile, Woolhiser, Lisa K., Lenaerts, Anne J., Reynolds, Robert C.

“…Eighteen new pyridopyrazine and pyrimidothiazine derivatives were synthesized and tested against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro…”
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A cell-based luminescence assay is effective for high-throughput screening of potential influenza antivirals by Noah, James W., Severson, William, Noah, Diana L., Rasmussen, Lynn, White, E. Lucile, Jonsson, Colleen B.

“…The spread of highly pathogenic avian influenza across geographical and species barriers underscores the increasing need for novel antivirals to compliment…”
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Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae by Tombline, Gregory, Millen, Jonathan I, Polevoda, Bogdan, Rapaport, Matan, Baxter, Bonnie, Van Meter, Michael, Gilbertson, Matthew, Madrey, Joe, Piazza, Gary A, Rasmussen, Lynn, Wennerberg, Krister, White, E Lucile, Nitiss, John L, Goldfarb, David S

“…A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that…”
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Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis by Goller, Carlos C, Arshad, Mehreen, Noah, James W, Ananthan, Subramaniam, Evans, Carrie W, Nebane, N Miranda, Rasmussen, Lynn, Sosa, Melinda, Tower, Nichole A, White, E Lucile, Neuenswander, Benjamin, Porubsky, Patrick, Maki, Brooks E, Rogers, Steven A, Schoenen, Frank, Seed, Patrick C

“…Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs), with over 100 million UTIs occurring annually…”
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Structure of Mycobacterium tuberculosis FtsZ Reveals Unexpected, G Protein-like Conformational Switches by Leung, Adelaine K.W., Lucile White, E., Ross, Larry J., Reynolds, Robert C., DeVito, Joseph A., Borhani, David W.

“…We report three crystal structures of the Mycobacterium tuberculosis cell division protein FtsZ, as the citrate, GDP, and GTPγS complexes, determined at 1.89,…”
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Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library by Severson, William E, Shindo, Nice, Sosa, Mindy, Fletcher, 3rd, Thomas, White, E Lucile, Ananthan, Subramaniam, Jonsson, Colleen B

“…The authors have developed a high-throughput screen (HTS) that allows for the identification of potential inhibitors of the severe acute respiratory syndrome…”
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Health utilities associated with nonmelanoma skin cancer by Alam, Murad, Kim, John Y.S., Swary, Jillian H., White, Lucile E., Ciurea, Ana, Dave, Loma, Brieva, Joaquin, Yoo, Simon

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Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen by Maddry, Joseph A, Chen, Xi, Jonsson, Colleen B, Ananthan, Subramaniam, Hobrath, Judith, Smee, Donald F, Noah, James W, Noah, Diana, Xu, Xiaolin, Jia, Fuli, Maddox, Clinton, Sosa, Melinda I, White, E Lucile, Severson, William E

“…A highly reproducible and robust cell-based high-throughput screening (HTS) assay was adapted for screening of small molecules for antiviral activity against…”
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