Search Results - "White, Deborah L."

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia by El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., Zeiser, Robert

“…Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) T cells is hampered by toxicity on normal hematopoietic progenitor…”
Get full text

RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL) by Rehn, Jacqueline, Mayoh, Chelsea, Heatley, Susan L, McClure, Barbara J, Eadie, Laura N, Schutz, Caitlin, Yeung, David T, Cowley, Mark J, Breen, James, White, Deborah L

“…RNA-sequencing (RNA-seq) efforts in acute lymphoblastic leukaemia (ALL) have identified numerous prognostically significant genomic alterations which can guide…”
Get full text

Multi-Cohort Transcriptomic Subtyping of B-Cell Acute Lymphoblastic Leukemia by Mäkinen, Ville-Petteri, Rehn, Jacqueline, Breen, James, Yeung, David, White, Deborah L

“…RNA sequencing provides a snapshot of the functional consequences of genomic lesions that drive acute lymphoblastic leukemia (ALL). The aims of this study were…”
Get full text

Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia by Kimura, Shunsuke, Montefiori, Lindsey, Iacobucci, Ilaria, Zhao, Yaqi, Gao, Qingsong, Paietta, Elisabeth M., Haferlach, Claudia, Laird, A. Douglas, Mead, Paul E., Gu, Zhaohui, Stock, Wendy, Litzow, Mark, Rowe, Jacob M., Luger, Selina M., Hunger, Stephen P., Ryland, Georgina L., Schmidt, Breon, Ekert, Paul G., Oshlack, Alicia, Grimmond, Sean M., Rehn, Jacqueline, Breen, James, Yeung, David, White, Deborah L., Aldoss, Ibrahim, Jabbour, Elias J., Pui, Ching-Hon, Meggendorfer, Manja, Walter, Wencke, Kern, Wolfgang, Haferlach, Torsten, Brady, Samuel, Zhang, Jinghui, Roberts, Kathryn G., Blombery, Piers, Mullighan, Charles G.

“…Transcriptome sequencing has identified multiple subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL) of prognostic significance, but a minority of…”
Get full text

ABCB1 Overexpression Is a Key Initiator of Resistance to Tyrosine Kinase Inhibitors in CML Cell Lines by Eadie, Laura N, Hughes, Timothy P, White, Deborah L

“…The tyrosine kinase inhibitor (TKI) imatinib has resulted in excellent responses in the majority of Chronic Myeloid Leukaemia (CML) patients; however,…”
Get full text

Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity by White, Deborah L., Saunders, Verity A., Dang, Phuong, Engler, Jane, Venables, Amity, Zrim, Stephanie, Zannettino, Andrew, Lynch, Kevin, Manley, Paul W., Hughes, Timothy

“…Interpatient variability in intracellular uptake and retention (IUR) of imatinib may be due to variable function of the OCT-1 influx pump. OCT-1 activity was…”
Get full text

The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism by Leow, Benjamin C. S., Kok, Chung H., Yeung, David T., Hughes, Timothy P., White, Deborah L., Eadie, Laura N.

“…In Chronic Myeloid Leukemia, the transition from drug sensitive to drug resistant disease is poorly understood. Here, we used exploratory sequencing of gene…”
Get full text

Gain of chromosome 21 increases the propensity for P2RY8: :CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression by Page, Elyse C, Heatley, Susan L, Rehn, Jacqueline, Thomas, Paul Q, Yeung, David T, White, Deborah L

“…Acute lymphoblastic leukemia (ALL) patients with a gain of chromosome 21, intrachromosomal amplification of chromosome 21 (iAMP21), or Down syndrome (DS), have…”
Get full text

Functional Activity of the OCT-1 Protein Is Predictive of Long-Term Outcome in Patients With Chronic-Phase Chronic Myeloid Leukemia Treated With Imatinib by WHITE, Deborah L, DANG, Phuong, ENGLER, Jane, FREDE, Amity, ZRIM, Stephanie, OSBORN, Michael, SAUNDERS, Verity A, MANLEY, Paul W, HUGHES, Timothy P

“…Organic cation transporter-1 (OCT-1) activity (OA), a measure of the OCT-1-mediated influx of imatinib into CML mononuclear cells (MNCs), is predictive of…”
Get full text

Solute Carrier Family 29A1 Mediates In Vitro Resistance to Azacitidine in Acute Myeloid Leukemia Cell Lines by Kutyna, Monika M, Loone, Sophie, Saunders, Verity A, White, Deborah L, Kok, Chung H, Hiwase, Devendra K

“…Azacitidine (AZA) is commonly used hypomethylating agent for higher risk myelodysplastic syndromes and acute myeloid leukemia (AML). Although some patients…”
Get full text

BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia by Pagani, Ilaria S, Dang, Phuong, Kommers, Ivar O, Goyne, Jarrad M, Nicola, Mario, Saunders, Verity A, Braley, Jody, White, Deborah L, Yeung, David T, Branford, Susan, Hughes, Timothy P, Ross, David M

“…Accurate quantification of minimal residual disease during treatment of chronic myeloid leukaemia guides clinical decisions. The conventional minimal residual…”
Get full text

ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells by Eadie, Laura N, Dang, Phuong, Goyne, Jarrad M, Hughes, Timothy P, White, Deborah L

“…ATP Binding Cassette family efflux proteins ABCB1 and ABCG2 have previously been demonstrated to interact with Tyrosine Kinase Inhibitors (TKIs); however,…”
Get full text

High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment by Heatley, Susan L, Sadras, Teresa, Kok, Chung H, Nievergall, Eva, Quek, Kelly, Dang, Phuong, McClure, Barbara, Venn, Nicola, Moore, Sarah, Suttle, Jeffrey, Law, Tamara, Ng, Anthea, Muskovic, Walter, Norris, Murray D, Revesz, Tamas, Osborn, Michael, Moore, Andrew S, Suppiah, Ram, Fraser, Chris, Alvaro, Frank, Hughes, Timothy P, Mullighan, Charles G, Marshall, Glenn M, Pozza, Luciano Dalla, Yeung, David T, Sutton, Rosemary, White, Deborah L

Get full text

Dasatinib Cellular Uptake and Efflux in Chronic Myeloid Leukemia Cells: Therapeutic Implications by HIWASE, Devendra K, SAUNDERS, Verity, HUGHES, Timothy P, WHITE, Deborah L, HEWETT, Duncan, FREDE, Amity, ZRIM, Stephanie, DANG, Phuong, EADIE, Laura, BIK TO, L, MELO, Junia, KUMAR, Sharad

“…Purpose: The organic cation transporter OCT-1 mediates active transport of imatinib. We recently showed that low OCT-1 activity is a major contributor to…”
Get full text

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy by Angelini, Sabrina, Soverini, Simona, Ravegnini, Gloria, Barnett, Matt, Turrini, Eleonora, Thornquist, Mark, Pane, Fabrizio, Hughes, Timothy P, White, Deborah L, Radich, Jerald, Kim, Dong Wook, Saglio, Giuseppe, Cilloni, Daniela, Iacobucci, Ilaria, Perini, Giovanni, Woodman, Richard, Cantelli-Forti, Giorgio, Baccarani, Michele, Hrelia, Patrizia, Martinelli, Giovanni

“…Imatinib has so far been the first-choice treatment in chronic myeloid leukemia with excellent results. However, only a proportion of patients achieve major…”
Get full text

Impact of early dose intensity on cytogenetic and molecular responses in chronic- phase CML patients receiving 600 mg/day of imatinib as initial therapy by Hughes, Timothy P., Branford, Susan, White, Deborah L., Reynolds, John, Koelmeyer, Rachel, Seymour, John F., Taylor, Kerry, Arthur, Chris, Schwarer, Anthony, Morton, James, Cooney, Julian, Leahy, Michael F., Rowlings, Philip, Catalano, John, Hertzberg, Mark, Filshie, Robin, Mills, Anthony K., Fay, Keith, Durrant, Simon, Januszewicz, Henry, Joske, David, Underhill, Craig, Dunkley, Scott, Lynch, Kevin, Grigg, Andrew

“…We conducted a trial in 103 patients with newly diagnosed chronic phase chronic myeloid leukemia (CP-CML) using imatinib 600 mg/day, with dose escalation to…”
Get full text

Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells by Wang, Jueqiong, Lu, Liu, Kok, Chung H, Saunders, Verity A, Goyne, Jarrad M, Dang, Phuong, Leclercq, Tamara M, Hughes, Timothy P, White, Deborah L

“…Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia…”
Get full text

Case Report: Precision Medicine Target Revealed by In Vitro Modeling of Relapsed, Refractory Acute Lymphoblastic Leukemia From a Child With Neurofibromatosis by Heatley, Susan L, Page, Elyse C, Eadie, Laura N, McClure, Barbara J, Rehn, Jacqueline, Yeung, David T, Osborn, Michael, Revesz, Tamas, Kirby, Maria, White, Deborah L

“…Children with neurofibromatosis have a higher risk of developing juvenile myelomonocytic leukemia and acute myeloid leukemia, but rarely develop B-cell acute…”
Get full text

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia by Downes, Charlotte E. J., McClure, Barbara J., Bruning, John B., Page, Elyse, Breen, James, Rehn, Jacqueline, Yeung, David T., White, Deborah L.

“…Ruxolitinib (rux) Phase II clinical trials are underway for the treatment of high-risk JAK2 -rearranged ( JAK2 r) B-cell acute lymphoblastic leukemia (B-ALL)…”
Get full text

JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies by Downes, Charlotte EJ, McClure, Barbara J., McDougal, Daniel P., Heatley, Susan L., Bruning, John B., Thomas, Daniel, Yeung, David T., White, Deborah L.

“…Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from immature lymphocytes that show uncontrolled proliferation and arrested…”
Get full text