Search Results - "White, David T."

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina by White, David T., Sengupta, Sumitra, Saxena, Meera T., Xu, Qingguo, Hanes, Justin, Ding, Ding, Ji, Hongkai, Mumm, Jeff S.

“…Müller glia (MG) function as inducible retinal stem cells in zebrafish, completely repairing the eye after damage. The innate immune system has recently been…”
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Evaluating human cancer cell metastasis in zebrafish by Teng, Yong, Xie, Xiayang, Walker, Steven, White, David T, Mumm, Jeff S, Cowell, John K

“…In vivo metastasis assays have traditionally been performed in mice, but the process is inefficient and costly. However, since zebrafish do not develop an…”
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Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses by Emmerich, Kevin, Walker, Steven L, Wang, Guohua, White, David T, Ceisel, Anneliese, Wang, Fang, Teng, Yong, Chunawala, Zeeshaan, Graziano, Gianna, Nimmagadda, Saumya, Saxena, Meera T, Qian, Jiang, Mumm, Jeff S

“…Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish and mice. In zebrafish, retinal regeneration is innate and…”
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ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates by White, David T, Eroglu, Arife Unal, Wang, Guohua, Zhang, Liyun, Sengupta, Sumitra, Ding, Ding, Rajpurohit, Surendra K, Walker, Steven L, Ji, Hongkai, Qian, Jiang, Mumm, Jeff S

“…White et al . present a protocol for ARQiv-HTS, a high-throughput reporter-based screening platform that can be used to examine the effects of chemical…”
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Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina by Emmerich, Kevin, White, David T., Kambhampati, Siva P., Casado, Grace L., Fu, Tian-Ming, Chunawala, Zeeshaan, Sahoo, Arpan, Nimmagadda, Saumya, Krishnan, Nimisha, Saxena, Meera T., Walker, Steven L., Betzig, Eric, Kannan, Rangaramanujam M., Mumm, Jeff S.

“…Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to…”
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First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass by Wang, Guangliang, Rajpurohit, Surendra K, Delaspre, Fabien, Walker, Steven L, White, David T, Ceasrine, Alexis, Kuruvilla, Rejji, Li, Ruo-Jing, Shim, Joong S, Liu, Jun O, Parsons, Michael J, Mumm, Jeff S

“…Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities…”
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Downregulation of Nodal inhibits metastatic progression in retinoblastoma by Asnaghi, Laura, White, David T, Yoon, Lynn, Price, Antoinette, Lee, Grace Y, Sahoo, Arpan, Mumm, Jeff S, Eberhart, Charles G

“…Retinoblastoma is the most common intraocular malignancy in children. We previously found that the ACVR1C/SMAD2 pathway is significantly upregulated in…”
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Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration by Unal Eroglu, Arife, Mulligan, Timothy S, Zhang, Liyun, White, David T, Sengupta, Sumitra, Nie, Cathy, Lu, Noela Y, Qian, Jiang, Xu, Lisha, Pei, Wuhong, Burgess, Shawn M, Saxena, Meera T, Mumm, Jeff S

“…Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia-an adult…”
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Let's get small (and smaller): Combining zebrafish and nanomedicine to advance neuroregenerative therapeutics by White, David T., Saxena, Meera T., Mumm, Jeff S.

“…Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably…”
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The nitroreductase system of inducible targeted ablation facilitates cell-specific regenerative studies in zebrafish by White, David T., Mumm, Jeff S.

“…•Cell-specific ablation provides new models for regenerative research in zebrafish.•Nitroreductase based ablation facilitates large-scale genetic and chemical…”
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NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation by Sharrock, Abigail V., Mulligan, Timothy S., Hall, Kelsi R., Williams, Elsie M., White, David T., Zhang, Liyun, Emmerich, Kevin, Matthews, Frazer, Nimmagadda, Saumya, Washington, Selena, Le, Katherine D., Meir-Levi, Danielle, Cox, Olivia L., Saxena, Meera T., Calof, Anne L., Lopez-Burks, Martha E., Lander, Arthur D., Ding, Ding, Ji, Hongkai, Ackerley, David F., Mumm, Jeff S.

“…Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells to prodrugs such as metronidazole (MTZ), enabling selective…”
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A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration by Emmerich, Kevin, Hageter, John, Hoang, Thanh, Lyu, Pin, Sharrock, Abigail V, Ceisel, Anneliese, Thierer, James, Chunawala, Zeeshaan, Nimmagadda, Saumya, Palazzo, Isabella, Matthews, Frazer, Zhang, Liyun, White, David T, Rodriguez, Catalina, Graziano, Gianna, Marcos, Patrick, May, Adam, Mulligan, Tim, Reibman, Barak, Saxena, Meera T, Ackerley, David F, Qian, Jiang, Blackshaw, Seth, Horstick, Eric, Mumm, Jeff S

“…Many genes are known to regulate retinal regeneration after widespread tissue damage. Conversely, genes controlling regeneration after limited cell loss, as…”
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ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma by Asnaghi, Laura, White, David T., Key, Nolan, Choi, Joshua, Mahale, Alka, Alkatan, Hind, Edward, Deepak P., Elkhamary, Sahar M., Al-Mesfer, Saleh, Maktabi, Azza, Hurtado, Christopher G., Lee, Grace Y., Carcaboso, Angel M., Mumm, Jeff S., Safieh, Leen Abu, Eberhart, Charles G.

“…Retinoblastoma is the most common intraocular cancer in children. While the primary tumor can often be treated by local or systemic chemotherapy, metastatic…”
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GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180 by White, David T, McShea, Katie M, Attar, Myriam A, Santy, Lorraine C

“…ARFs are small GTPases that regulate vesicular trafficking, cell shape, and movement. ARFs are subject to extensive regulation by a large number of accessory…”
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Delaware's Role in Handling the Rise of Dual-, Multi-, and Zero-Class Voting Structures by White, David T

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mechanical comparison of veterinary linear external fixation systems by White, D.T, Bronson, D.G, Welch, R.D

“…Objective— To compare the fixation rigidity of recently developed external fixation systems (EFSs) to that of the traditional Kirschner‐Ehmer (KE) system…”
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DELAWARE'S ROLE IN HANDLING THE RISE OF DUAL-, MULTI-, AND ZERO-CLASS VOTING STRUCTURES by White, David T

“…In many states, including Delaware,7 statutes were enacted that merely established "one share-one vote" as a default rule if no other rule was chosen by the…”
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