Search Results - "White, David P"

Defining Phenotypic Causes of Obstructive Sleep Apnea: Identification of Novel Therapeutic Targets by ECKERT, Danny J, WHITE, David P, JORDAN, Amy S, MALHOTRA, Atul, WELLMAN, Andrew

“…The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized. To define carefully the…”
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Metrics of sleep apnea severity: beyond the apnea-hypopnea index by Malhotra, Atul, Ayappa, Indu, Ayas, Najib, Collop, Nancy, Kirsch, Douglas, Mcardle, Nigel, Mehra, Reena, Pack, Allan I, Punjabi, Naresh, White, David P, Gottlieb, Daniel J

“…Abstract Obstructive sleep apnea (OSA) is thought to affect almost 1 billion people worldwide. OSA has well established cardiovascular and neurocognitive…”
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The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study by Azarbarzin, Ali, Sands, Scott A, Stone, Katie L, Taranto-Montemurro, Luigi, Messineo, Ludovico, Terrill, Philip I, Ancoli-Israel, Sonia, Ensrud, Kristine, Purcell, Shaun, White, David P, Redline, Susan, Wellman, Andrew

“…Abstract Aims Apnoea–hypopnoea index (AHI), the universal clinical metric of sleep apnoea severity, poorly predicts the adverse outcomes of sleep apnoea,…”
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The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial by Taranto-Montemurro, Luigi, Messineo, Ludovico, Sands, Scott A, Azarbarzin, Ali, Marques, Melania, Edwards, Bradley A, Eckert, Danny J, White, David P, Wellman, Andrew

“…There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and…”
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The Sleep Apnea-Specific Hypoxic Burden Predicts Incident Heart Failure by Azarbarzin, Ali, Sands, Scott A., Taranto-Montemurro, Luigi, Vena, Daniel, Sofer, Tamar, Kim, Sang-Wook, Stone, Katie L., White, David P., Wellman, Andrew, Redline, Susan

“…Heart failure (HF) is a leading cause of morbidity and mortality and although it is linked to sleep apnea, which physiological stressors most strongly…”
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Effects of the Combination of Atomoxetine and Oxybutynin on OSA Endotypic Traits by Taranto-Montemurro, Luigi, Messineo, Ludovico, Azarbarzin, Ali, Vena, Daniel, Hess, Lauren B., Calianese, Nicole A., White, David P., Wellman, Andrew, Sands, Scott A.

“…We recently showed that administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) prior to sleep…”
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Pathogenesis of Obstructive and Central Sleep Apnea by White, David P

“…Considerable progress has been made over the last several decades in our understanding of the pathophysiology of both central and obstructive sleep apnea…”
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Quantifying the Arousal Threshold Using Polysomnography in Obstructive Sleep Apnea by Sands, Scott A, Terrill, Philip I, Edwards, Bradley A, Taranto Montemurro, Luigi, Azarbarzin, Ali, Marques, Melania, de Melo, Camila M, Loring, Stephen H, Butler, James P, White, David P, Wellman, Andrew

“…Abstract Study Objectives Precision medicine for obstructive sleep apnea (OSA) requires noninvasive estimates of each patient’s pathophysiological “traits.”…”
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Obstructive sleep apnea in older adults is a distinctly different physiological phenotype by Edwards, Bradley A, Wellman, Andrew, Sands, Scott A, Owens, Robert L, Eckert, Danny J, White, David P, Malhotra, Atul

“…Current evidence suggests that the pathological mechanisms underlying obstructive sleep apnea (OSA) are altered with age. However, previous studies examining…”
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Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold by Eckert, Danny J, Owens, Robert L, Kehlmann, Geoffrey B, Wellman, Andrew, Rahangdale, Shilpa, Yim-Yeh, Susie, White, David P, Malhotra, Atul

“…Recent insights into sleep apnoea pathogenesis reveal that a low respiratory arousal threshold (awaken easily) is important for many patients. As most patients…”
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A method for measuring and modeling the physiological traits causing obstructive sleep apnea by WELLMAN, Andrew, ECKERT, Danny J, JORDAN, Amy S, EDWARDS, Bradley A, PASSAGLIA, Chris L, JACKSON, Andrew C, GAUTAM, Shiva, OWENS, Robert L, MALHOTRA, Atul, WHITE, David P

“…There is not a clinically available technique for measuring the physiological traits causing obstructive sleep apnea (OSA). Therefore, it is often difficult to…”
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Association between Reduced Sleep and Weight Gain in Women by Patel, Sanjay R., Malhotra, Atul, White, David P., Gottlieb, Daniel J., Hu, Frank B.

“…Physiologic studies suggest that sleep restriction has metabolic effects that predispose to weight gain. The authors investigated the association between…”
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Head rotation improves airway obstruction, especially in patients with less severe obstructive sleep apnea without oropharyngeal collapse by Tan, Shi Nee, Kim, Jong-Min, Kim, Jisun, Sung, Chung Man, Kim, Hong Chan, Lee, Jongho, Lim, Sang Chul, White, David P, Yang, Hyung Chae, Wellman, D Andrew

“…Head rotation is thought to have an effect on obstructive sleep apnea (OSA) severity. However, keeping the head rotated fully during sleep is difficult to…”
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Effect of oxygen in obstructive sleep apnea: Role of loop gain by Wellman, Andrew, Malhotra, Atul, Jordan, Amy S, Stevenson, Karen E, Gautam, Shiva, White, David P

“…Abstract We compared the effect of oxygen on the apnea–hypopnea index (AHI) in six obstructive sleep apnea patients with a relatively high loop gain (LG) and…”
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The influence of aging on pharyngeal collapsibility during sleep by Eikermann, Matthias, Jordan, Amy S, Chamberlin, Nancy L, Gautam, Shiva, Wellman, Andrew, Lo, Yu-Lun, White, David P, Malhotra, Atul

“…Aging increases vulnerability to obstructive sleep apnea (OSA), but the underlying mechanisms remain unclear. Recent data in awake healthy volunteers show a…”
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Pharmacologic Approaches to the Treatment of Obstructive Sleep Apnea by White, David P., MD

“…The concept of pharmacologic therapy for obstructive sleep apnea (OSA) treatment has always been considered but no agent has had a large enough effect size to…”
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Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea by ECKERT, Danny J, LO, Yu L, SABOISKY, Julian P, JORDAN, Amy S, WHITE, David P, MALHOTRA, Atul

“…Numerous studies have demonstrated upper-airway neuromuscular abnormalities during wakefulness in snorers and obstructive sleep apnea (OSA) patients. However,…”
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Airway Dilator Muscle Activity and Lung Volume During Stable Breathing in Obstructive Sleep Apnea by JORDAN, Amy S, WHITE, David P, LO, Yu-Lun, WELLMAN, Andrew, ECKERT, Danny J, YIM-YEH, Susie, EIKERMANN, Matthias, SMITH, Scott A, STEVENSON, Karen E, MALHOTRA, Atul

“…Many patients with obstructive sleep apnea (OSA) have spontaneous periods of stable flow limited breathing during sleep without respiratory events or arousals…”
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A Prospective Study of sleep duration and mortality risk in women by PATEL, Sanjay R, AYAS, Najib T, MALHOTRA, Mark R, WHITE, David P, SCHERNHAMMER, Eva S, SPEIZER, Frank E, STAMPFER, Meir J, HU, Frank B

“…It is commonly believed that 8 hours of sleep per night is optimal for good health. However, recent studies suggest the risk of death is lower in those…”
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A Prospective Study of Self-Reported Sleep Duration and Incident Diabetes in Women by AYAS, Najib T, WHITE, David P, AL-DELAIMY, Wael K, MANSON, Joann E, STAMPFER, Meir J, SPEIZER, Frank E, PATEL, Sanjay, HU, Frank B

“…A Prospective Study of Self-Reported Sleep Duration and Incident Diabetes in Women Najib T. Ayas , MD 1 2 , David P. White , MD 1 2 , Wael K. Al-Delaimy , MD,…”
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