Search Results - "White, Brian H."

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex by Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.

“…SIRT1, the founding member of the mammalian family of seven NAD + -dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended…”
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Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer by Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard

“…Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a 95% mortality rate with no improvement to treatment in decades, and new…”
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Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo by White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T

“…Somatostatin receptor 2 (SSTR2) is frequently overexpressed on several types of solid tumors, including neuroendocrine tumors and small-cell lung cancer…”
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Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors by Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.

“…The PI3K pathway is considered a master regulator for cancer due to its frequent activation, making it an attractive target for pharmacologic intervention…”
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Ring-Opening Metathesis/Oxy-Cope Rearrangement:  A New Strategy for the Synthesis of Bicyclic Medium Ring-Containing Compounds by White, Brian H, Snapper, Marc L

“…Ring-opening/ring-closing metathesis on cyclobutene-containing substrates with angular oxygen functionality provides a stereospecific introduction of…”
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Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo by White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.

“…Here we describe the discovery and the structure of PEN-221, a somatostatin receptor 2 (SSTR2) targeting peptide conjugated to DM1. PEN-221 is the first…”
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Abstract 3094: Discovery of a HeliconTM peptide inhibitor of the beta-catenin-TCF interaction with in vivo activity by White, Brian H., Si, Yaguang, Cappucci, Sarah, Li, Zhi, Ramirez, Jessica D., Ponthier, Charles M., Visness, Erica, Du, Peicheng, Choi, Minjung, Beerepoot, Pieter C., Ortet, Paula C., Jewett, Ivan T., Alfaro-Lopez, Josue, Agarwal, Sorabh, La, Daniel, Fulgham, Aaron, McGee, John H., Orford, Keith, Hurov, Jonathan B., Tremblay, Martin R., Verdine, Gregory L.

“…Wnt signaling pathway mutations leading to constitutive activation of the driver oncogene β-catenin occur in at least 20% of all human cancers, but β-catenin…”
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New methods for medium ring synthesis: Towards the total synthesis of clavirolide B by White, Brian H

“…Chapter 1. Review of the use of cyclobutenes in the total synthesis of natural products. Chapter 2. Presentation of a methodology for the synthesis of bicyclic…”
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New methods for medium ring synthesis: Towards the total synthesis of clavirolide B by White, Brian H

“…Chapter 1. Review of the use of cyclobutenes in the total synthesis of natural products. Chapter 2. Presentation of a methodology for the synthesis of bicyclic…”
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Effect of tornado loads on transmission lines by Ishac, M.F., White, H.B.

“…Of all the populated areas in Canada, Southwestern Ontario has experienced the highest tornado incidence and faces the greatest tornado damage. About 1 or 2…”
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A Practical Approach to Reliability Design by White, H. Brian

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A Modular Design System for Guyed-V Towers by White, H. Brian

“…Since their introduction in 1958, [1] guyed-V transmission structures have found acceptance in many parts of the world for long distance transmission lines…”
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Effect of tornado loads on transmission lines by Ishac, M.F., White, H.B.

“…Of all the populated areas in Canada, southwestern Ontario has experienced the highest tornado incidence and faces the greatest tornado damage. About 1 or 2…”
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