Search Results - "White, Andrew M."

Neoadjuvant enoblituzumab in localized prostate cancer: a single-arm, phase 2 trial by Shenderov, Eugene, De Marzo, Angelo M., Lotan, Tamara L., Wang, Hao, Chan, Sin, Lim, Su Jin, Ji, Hongkai, Allaf, Mohamad E., Chapman, Carolyn, Moore, Paul A., Chen, Francine, Sorg, Kristina, White, Andrew M., Church, Sarah E., Hudson, Briana, Fields, Paul A., Hu, Shaohui, Denmeade, Samuel R., Pienta, Kenneth J., Pavlovich, Christian P., Ross, Ashley E., Drake, Charles G., Pardoll, Drew M., Antonarakis, Emmanuel S.

“…B7 homolog 3 (B7-H3; CD276 ), a tumor-associated antigen and possible immune checkpoint, is highly expressed in prostate cancer (PCa) and is associated with…”
Get full text

Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy by Pearson, Jennifer N, Rowley, Shane, Liang, Li-Ping, White, Andrew M, Day, Brian J, Patel, Manisha

“…Abstract Cognitive dysfunction is an important comorbidity of temporal lobe epilepsy (TLE). However, no targeted therapies are available and the mechanisms…”
Get full text

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus by Williams, Philip A, White, Andrew M, Clark, Suzanne, Ferraro, Damien J, Swiercz, Waldemar, Staley, Kevin J, Dudek, F. Edward

“…Acquired epilepsy (i.e., after an insult to the brain) is often considered to be a progressive disorder, and the nature of this hypothetical progression…”
Get full text

The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling by Schlam, Ilana, Church, Sarah E, Hether, Tyler D, Chaldekas, Krysta, Hudson, Briana M, White, Andrew M, Maisonet, Emily, Harris, Brent T, Swain, Sandra M

“…The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has…”
Get full text

Characterization of neonatal seizures in an animal model of hypoxic‐ischemic encephalopathy by Sampath, Dayalan, White, Andrew M., Raol, Yogendra H.

“…Summary Objective In this study, we use time‐locked video and electroencephalography (EEG) recordings to characterize acute seizures and EEG abnormalities in…”
Get full text

Distribution of Defensive Metabolites in Nudibranch Molluscs by Winters, Anne E., White, Andrew M., Dewi, Ariyanti S., Mudianta, I. Wayan, Wilson, Nerida G., Forster, Louise C., Garson, Mary J., Cheney, Karen L.

“…Many plants and animals store toxic or unpalatable compounds in tissues that are easily encountered by predators during attack. Defensive compounds can be…”
Get full text

EEG power as a biomarker to predict the outcome after cardiac arrest and cardiopulmonary resuscitation induced global ischemia by Weitzel, Lindsay-rae, Sampath, Dayalan, Shimizu, Kaori, White, Andrew M., Herson, Paco S., Raol, Yogendra H.

“…Cardiac arrest (CA) is a major cause of mortality and survivors often develop neurologic deficits. The objective of this study was to determine the effect of…”
Get full text

Seizure-related regulation of GABAA receptors in spontaneously epileptic rats by González, Marco I, Grabenstatter, Heidi L, Cea-Del Rio, Christian A, Cruz Del Angel, Yasmin, Carlsen, Jessica, Laoprasert, Rick P, White, Andrew M, Huntsman, Molly M, Brooks-Kayal, Amy

“…Abstract In this study, we analyzed the impact that spontaneous seizures might have on the plasma membrane expression, composition and function of GABAA…”
Get full text

Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury by White, Andrew M., Williams, Philip A., Ferraro, Damien J., Clark, Suzanne, Kadam, Shilpa D., Dudek, F. Edward, Staley, Kevin J.

“…Long-term EEG monitoring in chronically epileptic animals produces very large EEG data files which require efficient algorithms to differentiate interictal…”
Get full text

Umpolung strategies for the functionalization of peptides and proteins by White, Andrew M, Palombi, Isabella R, Malins, Lara R

“…Umpolung strategies, defined as synthetic approaches which reverse commonly accepted reactivity patterns, are broadly recognized as enabling tools for small…”
Get full text

Sunflower Trypsin Inhibitor‐1 (SFTI‐1): Sowing Seeds in the Fields of Chemistry and Biology by Veer, Simon J., White, Andrew M., Craik, David J.

“…Nature‐derived cyclic peptides have proven to be a vast source of inspiration for advancing modern pharmaceutical design and synthetic chemistry. The focus of…”
Get full text

Total Synthesis of a Peptide Diatom Sex Pheromone Bearing a Sulfated Aspartic Acid by White, Andrew M., Schwartz, Brett D., Gardiner, Michael G., Malins, Lara R.

“…The peptide sex-inducing pheromone SIP+ (1) bearing an unusual sulfated aspartic acid residue induces sexual reproduction in diatom populations. Herein, we…”
Get full text

Cytotoxic Spiroepoxide Lactone and Its Putative Biosynthetic Precursor from Goniobranchus Splendidus by Forster, Louise C, Pierens, Gregory K, White, Andrew M, Cheney, Karen L, Dewapriya, Pradeep, Capon, Robert J, Garson, Mary J

“…Epoxygoniolide-1 (1), possessing spiroepoxide lactone, enal, and masked dialdehyde functionalities, has been characterized from the conspicuously patterned…”
Get full text

Discovery and optimization of peptide macrocycles by White, Andrew M, Craik, David J

“…Macrocyclic peptides are generally more resistant to proteolysis and often have higher potency than linear peptides and so they are excellent leads in drug…”
Get more information

Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy by Sampath, Dayalan, Valdez, Robert, White, Andrew M., Raol, Yogendra H.

“…Research studies suggest that neonatal seizures, which are most commonly associated with hypoxic-ischemic injury, may contribute to brain injury and adverse…”
Get full text

Development of Antiplasmodial Peptide–Drug Conjugates Using a Human Protein-Derived Cell-Penetrating Peptide with Selectivity for Infected Cells by Palombi, Isabella R., Lawrence, Nicole, White, Andrew M., Gare, Caitlin L., Craik, David J., McMorran, Brendan J., Malins, Lara R.

“…Malaria continues to impose a global health burden. Drug-resistant parasites have emerged to each introduced small-molecule therapy, highlighting the need for…”
Get full text

Flupirtine effectively prevents development of acute neonatal seizures in an animal model of global hypoxia by Sampath, Dayalan, Shmueli, Doron, White, Andrew M., Raol, Yogendra H.

“…•We examined efficacy of flupirtine to treat hypoxia-induced neonatal seizures.•Flupirtine blocks development of behavioral seizures during hypoxia.•Flupirtine…”
Get full text

Development of a Selective Peptide κ‑Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples by Muratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J., Gruber, Christian W.

“…The κ-opioid receptor (KOR) is an attractive target for the development of novel drugs. KOR agonists are potentially safer pain medications, whereas KOR…”
Get full text

Continuous Electroencephalographic Monitoring with Radio-Telemetry in a Rat Model of Perinatal Hypoxia-Ischemia Reveals Progressive Post-Stroke Epilepsy by Kadam, Shilpa D, White, Andrew M, Staley, Kevin J, Dudek, F. Edward

“…The development of acquired epilepsy after a perinatal hypoxic-ischemic (HI) insult was investigated in rats. After unilateral carotid ligation with hypoxia on…”
Get full text

Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides by White, Andrew M., Veer, Simon J., Wu, Guojie, Harvey, Peta J., Yap, Kuok, King, Gordon J., Swedberg, Joakim E., Wang, Conan K., Law, Ruby H. P., Durek, Thomas, Craik, David J.

“…Ruthenium‐catalysed azide–alkyne cycloaddition (RuAAC) provides access to 1,5‐disubstituted 1,2,3‐triazole motifs in peptide engineering applications. However,…”
Get full text