Search Results - "Whitcombe, Ian"

Nanoparticle Transport in Epithelial Cells: Pathway Switching Through Bioconjugation by Fowler, Robyn, Vllasaliu, Driton, Trillo, Francisco Fernández, Garnett, Martin, Alexander, Cameron, Horsley, Helen, Smith, Bryan, Whitcombe, Ian, Eaton, Mike, Stolnik, Snow

“…The understanding and control of nanoparticle transport into and through cellular compartments is central to biomedical applications of nanotechnology. Here,…”
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Atropisomeric small molecule Bcl-2 ligands: Determination of bioactive conformation by Porter, John, Payne, Andrew, Whitcombe, Ian, de Candole, Ben, Ford, Daniel, Garlish, Rachel, Hold, Adam, Hutchinson, Brian, Trevitt, Graham, Turner, James, Edwards, Chloe, Watkins, Clare, Davis, Jeremy, Stubberfield, Colin

“…Determination of the bioactive conformation of a series of atropisomeric Bcl-2 inhibitors is reported. The separation of atropisomeric conformers of…”
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The synthesis of the glucuronide adduct of Trocade by Mitchell, Mark B, Whitcombe, Ian W.A

“…The synthetic preparation of the glucuronide adduct of Trocade™, a selective inhibitor of the MMP collagenase, is described. This was achieved by preparation…”
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Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors by Porter, John, Payne, Andrew, de Candole, Ben, Ford, Daniel, Hutchinson, Brian, Trevitt, Graham, Turner, James, Edwards, Chloe, Watkins, Clare, Whitcombe, Ian, Davis, Jeremy, Stubberfield, Colin

“…The SAR of a series of small molecule Bcl-2 inhibitors is reported. Anti-apoptotic Bcl-2 protects cells from apoptosis by binding to pro-apoptotic members of…”
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Automated Protein–Ligand Interaction Screening by Mass Spectrometry by Maple, Hannah J, Garlish, Rachel A, Rigau-Roca, Laura, Porter, John, Whitcombe, Ian, Prosser, Christine E, Kennedy, Jeff, Henry, Alistair J, Taylor, Richard J, Crump, Matthew P, Crosby, John

“…Identifying protein–ligand binding interactions is a key step during early-stage drug discovery. Existing screening techniques are often associated with…”
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4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase by Alexander, Rikki, Balasundaram, Ahrani, Batchelor, Mark, Brookings, Daniel, Crépy, Karen, Crabbe, Tom, Deltent, Marie-France, Driessens, Frank, Gill, Andrew, Harris, Sue, Hutchinson, Gillian, Kulisa, Claire, Merriman, Mark, Mistry, Prakash, Parton, Ted, Turner, James, Whitcombe, Ian, Wright, Sara

“…4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase, compound 18 is shown to…”
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Identification of Differential Protein Binding Affinities in an Atropisomeric Pharmaceutical Compound by Noncovalent Mass Spectrometry, Equilibrium Dialysis, and Nuclear Magnetic Resonance by Maple, Hannah J, Garlish, Rachel A, Whitcombe, Ian, Hold, Adam, Prosser, Christine E, Ford, Daniel, Mackenzie, Harry, Crosby, John, Porter, John, Taylor, Richard J, Crump, Matthew P

“…Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs ( Angew. Chem., Int. Ed. 2009, 48, 6398−6401 ). Strategies for…”
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Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.) by Wang, Yulan, Tang, Huiru, Nicholson, Jeremy K, Hylands, Peter J, Sampson, Julia, Whitcombe, Ian, Stewart, Christopher G, Caiger, Steve, Oru, Isaac, Holmes, Elaine

“…In order to improve the accuracy and consistency of control phytomedicine preparations worldwide, regulatory authorities are requesting research into new…”
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Prediction of anti-plasmodial activity of Artemisia annua extracts: application of [formula omitted] NMR spectroscopy and chemometrics by Bailey, Nigel J.C., Wang, Yulan, Sampson, Julia, Davis, Wendy, Whitcombe, Ian, Hylands, Peter J., Croft, Simon L., Holmes, Elaine

“…We describe the application of 1 H NMR spectroscopy and chemometrics to the analysis of extracts of Artemisia annua. This approach allowed the discrimination…”
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Prediction of anti-plasmodial activity of Artemisia annua extracts: Application of 1H NMR spectroscopy and chemometrics by BAILEY, Nigel J. C, YULAN WANG, SAMPSON, Julia, DAVIS, Wendy, WHITCOMBE, Ian, HYLANDS, Peter J, CROFT, Simon L, HOLMES, Elaine

“…We describe the application of 1H NMR spectroscopy and chemometrics to the analysis of extracts of Artemisia annua. This approach allowed the discrimination of…”
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Fluorination of (+)-chiro-inositol with SF4/HF to give 2α,3β-difluoro-7-oxabicyclo[2.2.1]heptane-5α,6α-sulfite by Coe, Paul L., Maunder, Peter, Frampton, Christopher S., Martin, Joseph A., Anthony Thomas, W., Whitcombe, Ian W.A.

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Fluorination of (+)- chiro-inositol with SF 4/HF to give 2α,3β-difluoro-7-oxabicyclo[2.2.1]heptane-5α,6α-sulfite by Coe, Paul L., Maunder, Peter, Frampton, Christopher S., Martin, Joseph A., Anthony Thomas, W., Whitcombe, Ian W.A.

“…Graphic The fluorination of (+)- chiro-inositol with SF 4/HF under moderate conditions affords a single product studied by 1 H and 19 F and 13 C NMR…”
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Stratigraphic and structural architecture of the San Joaquin-Sacramento basin by Moxon, Ian Whitcombe

“…Tectonic processes governing subsidence and uplift patterns of forearc basins are poorly understood compared with rift and foreland basins. Two fundamental…”
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