Search Results - "Whitcomb, Luke A"

Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation by Catandi, Giovana D., Fresa, Kyle J., Cheng, Ming-Hao, Whitcomb, Luke A., Broeckling, Corey D., Chen, Thomas W., Chicco, Adam J., Carnevale, Elaine M.

“…Obesity is a growing concern in human and equine populations, predisposing to metabolic pathologies and reproductive disturbances. Cellular lipid accumulation…”
Get full text

Cryopreservation of equine spermatozoa reduces plasma membrane integrity and phospholipase C zeta 1 content as associated with oocyte activation by Gonzalez-Castro, Raul A, Whitcomb, Luke A, Pinsinski, Emma C, Carnevale, Elaine M

“…Phospholipase C zeta (PLCZ1) is considered the major sperm-borne oocyte activation factor. Cryopreserved stallion spermatozoa are commonly used for…”
Get full text

Characterization of trophoblast mitochondrial function and responses to testosterone treatment in ACH-3P cells by Parsons, Agata M., Rajendran, Ranjitha Raja, Whitcomb, Luke A., Bouma, Gerrit J., Chicco, Adam J.

“…Trophoblast mitochondria play important roles in placental energy metabolism, physiology and pathophysiology. Hyperandrogenism has been associated with…”
Get full text

Transient absorption spectroscopy and imaging of redox in muscle mitochondria by Wang, Erkang, Whitcomb, Luke A, Chicco, Adam J, Wilson, Jesse W

“…Mitochondrial redox is an important indicator of cell metabolism and health, with implications in cancer, diabetes, aging, neurodegenerative diseases, and…”
Get full text

Modeling ionizing radiation-induced cardiovascular dysfunction with human iPSC-derived engineered heart tissues by Cao, Xu, Thomas, Dilip, Whitcomb, Luke A., Wang, Mingqiang, Chatterjee, Anushree, Chicco, Adam J., Weil, Michael M., Wu, Joseph C.

Get full text

Mitochondrial reactive oxygen species impact human fibroblast responses to protracted γ-ray exposures by Whitcomb, Luke A, Cao, Xu, Thomas, Dilip, Wiese, Claudia, Pessin, Alissa S, Zhang, Robert, Wu, Joseph C, Weil, Michael M, Chicco, Adam J

“…Continuous exposure to ionizing radiation at a low dose rate poses significant health risks to humans on deep space missions, prompting the need for…”
Get full text

High-fat diet during pregnancy promotes fetal skeletal muscle fatty acid oxidation and insulin resistance in an ovine model by Omar, Asma K, Li Puma, Lance C, Whitcomb, Luke A, Risk, Briana D, Witt, Aria C, Bruemmer, Jason E, Winger, Quinton A, Bouma, Gerrit J, Chicco, Adam J

“…Maternal diet during pregnancy is associated with offspring metabolic risk trajectory in humans and animal models, but the prenatal origins of these effects…”
Get more information

Long‐chain fatty acid oxidation and respiratory complex I deficiencies distinguish Barth Syndrome from idiopathic pediatric cardiomyopathy by Chatfield, Kathryn C., Sparagna, Genevieve C., Specht, Kalyn S., Whitcomb, Luke A., Omar, Asma K., Miyamoto, Shelley D., Wolfe, Lisa M., Chicco, Adam J.

“…Barth syndrome (BTHS) is an X‐linked disorder that results from mutations in the TAFAZZIN gene, which encodes a phospholipid transacylase responsible for…”
Get full text

Beta-hydroxybutyrate mitigates bioenergetic deficits in the Tafazzin shRNA mouse model of Barth Syndrome by Whitcomb, Luke A., Geiger, Jacob E., Sikes, Katie J., Chicco, Adam J.

Get full text