Search Results - "Whitacre, M"

The origins of cancer robustness and evolvability by Tian, Tianhai, Olson, Sarah, Whitacre, James M, Harding, Angus

“…Unless diagnosed early, many adult cancers remain incurable diseases. This is despite an intense global research effort to develop effective anticancer…”
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The effect of corneal thickness on applanation tonometry by Whitacre, M M, Stein, R A, Hassanein, K

“…Simultaneous manometry and Perkins tonometry were performed at 10.0, 20.0, and 30.0 mm Hg on 15 eyes on which intraocular procedures were performed. There was…”
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Sources of error with use of Goldmann-type tonometers by Whitacre, M M, Stein, R

“…There are many sources of error in the use of Goldmann-type applanation tonometers. In clinically normal corneas hypofluorescence of the precorneal tear film,…”
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Pharmacologic Disruption of Base Excision Repair Sensitizes Mismatch Repair-deficient and -proficient Colon Cancer Cells to Methylating Agents by LIU, L, TAVERNA, P, WHITACRE, C. M, CHATTERJEE, S, GERSON, S. L

“…Previously we showed that a mismatch repair (MMR)-deficient cell line, HCT116 (hMLH1 mut), unlike a MMR wild-type cell line, SW480, was more resistant to the…”
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B‐mode and Doppler ultrasonography in pony mares with experimentally induced ascending placentitis by Bailey, C. S., Heitzman, J. M., Buchanan, C. N., Bare, C. A., Sper, R. B., Borst, L. B., Macpherson, M., Archibald, K., Whitacre, M.

“…REASONS FOR PERFORMING STUDY: Early, accurate diagnosis of ascending placentitis in mares remains a key challenge for successful treatment of the disease…”
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Uterine artery blood flow remains unchanged in pregnant mares in response to short-term administration of pentoxifylline by Bailey, C.S, Sper, R.B, Schewmaker, J.L, Buchanan, C.N, Beachler, T.M, Pozor, M.A, Whitacre, M.D

“…The objective of this study was to use Doppler ultrasound technology to determine whether pentoxifylline administration increased uterine blood flow in normal…”
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The Self-Organization of Interaction Networks for Nature-Inspired Optimization by Whitacre, J.M., Sarker, R.A., Pham, Q.T.

“…Over the last decade, significant progress has been made in understanding complex biological systems, however, there have been few attempts at incorporating…”
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Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses by SCHRAMME, A. R., PINTO, C. R. F., DAVIS, J., WHISNANT, C. S., WHITACRE, M. D.

“…Summary Reason for performing study: Current therapy protocols to treat persistent post mating endometritis and retained fetal membranes in mares typically…”
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Degeneracy: a link between evolvability, robustness and complexity in biological systems by Whitacre, James M

“…A full accounting of biological robustness remains elusive; both in terms of the mechanisms by which robustness is achieved and the forces that have caused…”
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Haemoperitoneum in a pregnant mare with an ovarian haematoma by Beachler, T. M., Bailey, C. S., McKelvey, K. A., Davis, J. L., Edwards, A., Diaw, M., Vasgaard, J. M., Whitacre, M. D.

“…Summary Haemoperitoneum is a rarely reported but life‐threatening complication of a multitude of disease processes that can affect horses. This report…”
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New Isolation Technique to Study Apoptosis in Human Intestinal Epithelial Cells by Grossmann, Johannes, Maxson, Julie M., Whitacre, Cecilia M., Orosz, David E., Berger, Nathan A., Fiocchi, Claudio, Levine, Alan D.

“…Intestinal epithelial cells derive from stem cells at the base of the crypt and migrate along the crypt-lumen axis. Their life is terminated as they reach the…”
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Photodynamic Therapy with the Phthalocyanine Photosensitizer Pc 4 of SW480 Human Colon Cancer Xenografts in Athymic Mice by Whitacre, C M, Feyes, D K, Satoh, T, Grossmann, J, Mulvihill, J W, Mukhtar, H, Oleinick, N L

“…Photodynamic therapy (PDT) using the silicon phthalocyanine photosensitizer Pc 4[ HOSiPcOSi(CH 3 ) 2 (CH 2 ) 3 N-(CH 3 ) 2 ] is an oxidative stress associated…”
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Protease activation and cleavage of poly(ADP-ribose) polymerase : An integral part of apoptosis in response to photodynamic treatment by JIN HE, WHITACRE, C. M, XUE, L.-Y, BERGER, N. A, OLEINICK, N. L

“…Apoptosis induced by numerous cancer chemotherapeutic and other toxic agents has been shown to proceed through a cascade of proteases, now termed caspases,…”
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Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences by WHITACRE, C. M, HASHIMOTO, H, MIN-LUNG TSAI, SATADAL CHATTERJEE, BERGER, S. J, BERGER, N. A

“…We have used two different approaches to study the consequences of NAD/poly(ADP-ribose) deficiency on p53 expression and its activity in V79-derived cell…”
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Recent trends indicate rapid growth of nature-inspired optimization in academia and industry by Whitacre, James M.

“…Although researchers often comment on the popularity of nature-inspired meta-heuristics (NIM), there has been very little empirical data to support the claim…”
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Survival of the flexible: explaining the recent popularity of nature-inspired optimization within a rapidly evolving world by Whitacre, James M.

“…Researchers often comment on the popularity and potential of nature-inspired meta-heuristics (NIM), however there has been a paucity of data to directly…”
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The effect of excimer laser photorefractive keratectomy on intraocular pressure measurements using the Goldmann applanation tonometer by Mardelli, P G, Piebenga, L W, Whitacre, M M, Siegmund, K D

“…The authors determined whether photorefractive keratectomy (PRK) affects Goldmann applanation readings in human eyes. The intraocular pressure (IOP) of 111…”
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Detection of Poly(ADP-ribose) Polymerase Cleavage in Response to Treatment with Topoisomerase I Inhibitors: A Potential Surrogate End Point to Assess Treatment Effectiveness by WHITACRE, C. M, ZBOROWSKA, E, WILLSON, J. K. V, BERGER, N. A

“…Cleavage of poly(ADP-ribose) polymerase (PARP) by caspases is a prominent characteristic of apoptosis or programmed cell death shown to be induced by…”
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Effects of anti-inflammatory drugs following cataract extraction by Simone, Joseph N, Whitacre, Marc M

“…Cycloplegics, corticosteroids, and nonsteroidal anti-inflammatory drugs have been applied in the treatment of postoperative inflammation following cataract…”
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Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems by Whitacre, James M, Bender, Axel

“…A generic mechanism--networked buffering--is proposed for the generation of robust traits in complex systems. It requires two basic conditions to be satisfied:…”
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