Search Results - "Whitacre, James M."

The origins of cancer robustness and evolvability by Tian, Tianhai, Olson, Sarah, Whitacre, James M, Harding, Angus

“…Unless diagnosed early, many adult cancers remain incurable diseases. This is despite an intense global research effort to develop effective anticancer…”
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Degeneracy: a link between evolvability, robustness and complexity in biological systems by Whitacre, James M

“…A full accounting of biological robustness remains elusive; both in terms of the mechanisms by which robustness is achieved and the forces that have caused…”
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Recent trends indicate rapid growth of nature-inspired optimization in academia and industry by Whitacre, James M.

“…Although researchers often comment on the popularity of nature-inspired meta-heuristics (NIM), there has been very little empirical data to support the claim…”
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Survival of the flexible: explaining the recent popularity of nature-inspired optimization within a rapidly evolving world by Whitacre, James M.

“…Researchers often comment on the popularity and potential of nature-inspired meta-heuristics (NIM), however there has been a paucity of data to directly…”
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Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems by Whitacre, James M, Bender, Axel

“…A generic mechanism--networked buffering--is proposed for the generation of robust traits in complex systems. It requires two basic conditions to be satisfied:…”
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Genetic and environment-induced pathways to innovation: on the possibility of a universal relationship between robustness and adaptation in complex biological systems by Whitacre, James M.

“…Recently, there has been considerable interest in the idea that mutational robustness enhances the propensity for future adaptations, i.e. evolvability, if…”
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Degeneracy allows for both apparent homogeneity and diversification in populations by Whitacre, James M., Atamas, Sergei P.

“…Trait diversity – the substrate for natural selection – is necessary for adaptation through selection, particularly in populations faced with environmental…”
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Evolutionary mechanics: new engineering principles for the emergence of flexibility in a dynamic and uncertain world by Whitacre, James M., Rohlfshagen, Philipp, Bender, Axel, Yao, Xin

“…Engineered systems are designed to deftly operate under predetermined conditions yet are notoriously fragile when unexpected perturbations arise. In contrast,…”
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The Self-Organization of Interaction Networks for Nature-Inspired Optimization by Whitacre, J.M., Sarker, R.A., Pham, Q.T.

“…Over the last decade, significant progress has been made in understanding complex biological systems, however, there have been few attempts at incorporating…”
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T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation by Whitacre, James M, Lin, Joseph, Harding, Angus

“…Evolution is often characterized as a process involving incremental genetic changes that are slowly discovered and fixed in a population through genetic drift…”
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Recent trends indicate rapid growth of nature-inspired optimization in academia and industry: Bio-inspired Computing by WHITACRE, James M

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Survival of the flexible: explaining the recent popularity of nature-inspired optimization within a rapidly evolving world: Bio-inspired Computing by WHITACRE, James M

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Making and breaking power laws in evolutionary algorithm population dynamics by Whitacre, James M., Sarker, Ruhul A., Pham, Q. Tuan

“…Deepening our understanding of the characteristics and behaviors of population-based search algorithms remains an important ongoing challenge in Evolutionary…”
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Performance analysis of elitism in multi-objective ant colony optimization algorithms by Bui, L.T., Whitacre, J.M., Abbass, H.A.

“…This paper investigates the effect of elitism on multi-objective ant colony optimization algorithms (MACOs). We use a straightforward and systematic approach…”
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Evidence of coevolution in multi-objective evolutionary algorithms by Whitacre, James M

“…WorldComp 2009, Las Vegas, NV, USA This paper demonstrates that simple yet important characteristics of coevolution can occur in evolutionary algorithms when…”
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Adaptation and Self-Organization in Evolutionary Algorithms by Whitacre, James M

“…Abbreviated Abstract: The objective of Evolutionary Computation is to solve practical problems (e.g. optimization, data mining) by simulating the mechanisms of…”
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Survival of the flexible: explaining the recent dominance of nature-inspired optimization within a rapidly evolving world by Whitacre, James M

“…Although researchers often comment on the rising popularity of nature-inspired meta-heuristics (NIM), there has been a paucity of data to directly support the…”
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Networked buffering: a basic mechanism for distributed robustness in complex adaptive systems by Whitacre, James M, Bender, Axel

“…Here we propose a generic mechanism - networked buffering - for generating robust traits in complex systems that requires two basic conditions to be satisfied:…”
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Degeneracy: a design principle for achieving robustness and evolvability by Whitacre, James M, Bender, Axel

“…Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies…”
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The Diversity Paradox: How Nature Resolves an Evolutionary Dilemma by Whitacre, James M, Atamas, Sergei P

“…Adaptation to changing environments is a hallmark of biological systems. Diversity in traits is necessary for adaptation and can influence the survival of a…”
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