Search Results - "Whissell, Paul D"

Tranexamic acid-associated seizures: Causes and treatment by Lecker, Irene, Wang, Dian-Shi, Whissell, Paul D., Avramescu, Sinziana, Mazer, C. David, Orser, Beverley A.

“…Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a wide range of hemorrhagic conditions. The most commonly used…”
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The Use of DREADDs to Deconstruct Behavior by Whissell, Paul D, Tohyama, Sarasa, Martin, Loren J

“…A central goal in understanding brain function is to link specific cell populations to behavioral outputs. In recent years, the selective targeting of specific…”
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Comparative density of CCK- and PV-GABA cells within the cortex and hippocampus by Whissell, Paul D, Cajanding, Janine D, Fogel, Nicole, Kim, Jun Chul

“…Cholecystokinin (CCK)- and parvalbumin (PV)-expressing neurons constitute the two major populations of perisomatic GABAergic neurons in the cortex and the…”
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Selective Activation of Cholecystokinin-Expressing GABA (CCK-GABA) Neurons Enhances Memory and Cognition by Whissell, Paul D, Bang, Jee Yoon, Khan, Ikram, Xie, Yu-Feng, Parfitt, Gustavo M, Grenon, Martine, Plummer, Nicholas W, Jensen, Patricia, Bonin, Robert P, Kim, Jun Chul

“…Cholecystokinin-expressing GABAergic (CCK-GABA) neurons are perisomatic inhibitory cells that have been argued to regulate emotion and sculpt the network…”
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Altered expression of δGABAA receptors in health and disease by Whissell, Paul D., Lecker, Irene, Wang, Dian-Shi, Yu, Jieying, Orser, Beverley A.

“…γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are expressed in multiple types of neurons throughout the central nervous…”
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Cage-lid hanging behavior as a translationally relevant measure of pain in mice by Zhang, Hantao, Lecker, Irene, Collymore, Chereen, Dokova, Anastassia, Pham, Maian Christine, Rosen, Sarah F., Crawhall-Duk, Hayley, Zain, Maham, Valencia, Megan, Filippini, Helena Fetter, Li, Jerry, D'Souza, Abigail J., Cho, Chulmin, Michailidis, Vassilia, Whissell, Paul D., Patel, Ingita, Steenland, Hendrik W., Virginia Lee, Wai-Jane, Moayedi, Massieh, Sterley, Toni-Lee, Bains, Jaideep S., Stratton, Jo Anne, Matyas, John R., Biernaskie, Jeff, Dubins, David, Vukobradovic, Igor, Bezginov, Alexandr, Flenniken, Ann M., Martin, Loren J., Mogil, Jeffrey S., Bonin, Robert P.

“…The development of new analgesic drugs has been hampered by the inability to translate preclinical findings to humans. This failure is due in part to the weak…”
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δGABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior by Whissell, Paul D, Avramescu, Sinziana, Wang, Dian-Shi, Orser, Beverley A

“…BACKGROUND:Extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that contain the δ subunit (δGABAA receptors) contribute to memory performance…”
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Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury by Khodaei, Shahin, Avramescu, Sinziana, Wang, Dian-Shi, Sheng, Heping, Chan, Nathan K., Lecker, Irene, Fernandez-Escobar, Alejandro, Lei, Gang, Dewar, Michael B., Whissell, Paul D., Baker, Andrew J., Orser, Beverley A.

“…OBJECTIVES:Cognitive deficits after traumatic brain injury are a leading cause of disability worldwide, yet no effective pharmacologic treatments exist to…”
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Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury by Khodaei, Shahin, Avramescu, Sinziana, Wang, Dian-Shi, Sheng, Heping, Chan, Nathan K, Lecker, Irene, Fernandez-Escobar, Alejandro, Lei, Gang, Dewar, Michael B, Whissell, Paul D, Baker, Andrew J, Orser, Beverley A

“…Cognitive deficits after traumatic brain injury are a leading cause of disability worldwide, yet no effective pharmacologic treatments exist to improve…”
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Inflammation Increases Neuronal Sensitivity to General Anesthetics by Avramescu, Sinziana, Wang, Dian-Shi, Lecker, Irene, To, William T H, Penna, Antonello, Whissell, Paul D, Mesbah-Oskui, Lia, Horner, Richard L, Orser, Beverley A

“…BACKGROUND:Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms…”
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γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus by Whissell, Paul D., Rosenzweig, Shira, Lecker, Irene, Wang, Dian-Shi, Wojtowicz, J. Martin, Orser, Beverley A.

“…Objective Extrasynaptic γ‐aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are highly expressed in the dentate gyrus (DG)…”
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Pharmacological enhancement of δ-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice by Bonin, Robert P., Labrakakis, Charalampos, Eng, David G., Whissell, Paul D., De Koninck, Yves, Orser, Beverley A.

“…The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether…”
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Pharmacological enhancement of δ-subunit-containing GABA A receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice by Bonin, Robert P., Labrakakis, Charalampos, Eng, David G., Whissell, Paul D., Koninck, Yves De, Orser, Beverley A.

“…The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether…”
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Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus by Whissell, Paul D, Eng, Dave, Lecker, Irene, Martin, Loren J, Wang, Dian-Shi, Orser, Beverley A

“…Extrasynaptic γ-aminobutyric acid type A (GABA(A)) receptors that contain the δ subunit (δGABA(A) receptors) are expressed in several brain regions including…”
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Neurodevelopmental anomalies of the hippocampus in rats exposed to weak intensity complex magnetic fields throughout gestation by Fournier, Neil M., Mach, Quoc Hao, Whissell, Paul D., Persinger, Michael A.

“…► The effect of prenatal exposure to a complex magnetic field on the adult hippocampus was examined. ► Prenatal exposures decreases CA1 and CA3 pyramidal cell…”
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Altered expression of delta GABA sub(A) receptors in health and disease by Whissell, Paul D, Lecker, Irene, Wang, Dian-Shi, Yu, Jieying, Orser, Beverley A

“…gamma -Aminobutyric acid type A receptors that contain the delta subunit ( delta GABA sub(A) receptors) are expressed in multiple types of neurons throughout…”
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[gamma]-aminobutyric acid type A receptors that contain the [delta] subunit promote memory and neurogenesis in the dentate gyrus by Whissell, Paul D, Rosenzweig, Shira, Lecker, Irene, Wang, Dian-Shi, Wojtowicz, J Martin, Orser, Beverley A

“…Objective Extrasynaptic [gamma]-aminobutyric acid type A receptors that contain the [delta] subunit ([delta]GABAA receptors) are highly expressed in the…”
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Acutely increasing δGABAA receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus by Whissell, Paul D., Eng, Dave, Lecker, Irene, Martin, Loren J., Wang, Dian-Shi, Orser, Beverley A.

“…Extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that contain the δ subunit (δGABAA receptors) are expressed in several brain regions including the…”
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