Search Results - "Whetton, A."

Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches by Pearson, S, Williamson, A J K, Blance, R, Somervaille, T C P, Taylor, S, Azadbakht, N, Whetton, A D, Pierce, A

“…In excess of 90% of patients with polycythaemia vera (PV) express a mutated form of Janus kinase 2 (JAK2), JAK2V617F. Such aberrant proteins offer great…”
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Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches by Pearson, S, Williamson, A J K, Blance, R, Somervaille, T C P, Taylor, S, Azadbakht, N, Whetton, A D, Pierce, A

“…This corrects the article DOI: 10.1038/leu.2017.143…”
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504: Functional proteomic analysis of leukaemogenic protein tyrosine kinase targets by Che Azmi, N, Pierce, A, Williamson, A, Whetton, A

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A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5 by Griaud, F, Pierce, A, Gonzalez Sanchez, M B, Scott, M, Abraham, S A, Holyoake, T L, Tran, D D H, Tamura, T, Whetton, A D

“…THOC5 is a member of the THO complex that is involved in processing and transport of mRNA. We have shown previously that hematopoietic stem cells have an…”
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A caspase-3 ‘death-switch’ in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers by Simpson, K L, Cawthorne, C, Zhou, C, Hodgkinson, C L, Walker, M J, Trapani, F, Kadirvel, M, Brown, G, Dawson, M J, MacFarlane, M, Williams, K J, Whetton, A D, Dive, C

“…Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the…”
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A proof‐of‐principle gel‐free proteomics strategy for the identification of predictive biomarkers for the onset of pre‐eclampsia by Blankley, RT, Gaskell, SJ, Whetton, AD, Dive, C, Baker, PN, Myers, JE

“…Objective  Progress in the prevention and treatment of women at risk of pre‐eclampsia (PE) still remains hindered by the lack of clinical screening tools that…”
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Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation by Tran, D DH, Saran, S, Dittrich-Breiholz, O, Williamson, A JK, Klebba-Färber, S, Koch, A, Kracht, M, Whetton, A D, Tamura, T

“…Hematopoiesis and commitment to a restricted lineage are guided by a timely expressed set of cytokine receptors and their downstream transcription factors. A…”
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FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C EBPalpha by MANCINI, A, EL BOUNKARI, O, TAMURA, T, NORRENBROCK, A.-F, SCHERR, M, SCHAEFER, D, EDER, M, BANHAM, A. H, PULFORD, K, LYNE, L, WHETTON, A. D

“…Fms interacting protein (FMIP) is a substrate for Fms tyrosine kinase, and a nuclear/cytoplasm shuttling protein with a leucine zipper. As the phosphorylation…”
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The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells by Burthem, J, Rees-Unwin, K, Mottram, R, Adams, J, Lucas, G S, Spooncer, E, Whetton, A D

“…Evidence from cell line-based studies indicates that rho-kinase may play a role in the leukaemic transformation of human cells mediated by the BCR/ABL tyrosine…”
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Bone marrow innervation regulates cellular retention in the murine haemopoietic system by Afan, A. M., Broome, C. S., Nicholls, S. E., Whetton, A. D., Miyan, J. A.

“…An anatomical analysis of the innervation of murine femora revealed intimate association of haemopoietic and stromal cells with nerve fibres. The mechanical…”
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Role of the C‐terminal actin binding domain in BCR/ABL‐mediated survival and drug resistance by Underhill‐Day, N., Pierce, A., Thompson, S. E., Xenaki, D., Whetton, A. D., Owen‐Lynch, P. J.

“…Summary Philadelphia chromosome‐positive, chronic myeloid leukaemia (CML) stem and progenitor cells have a survival and growth advantage compared with their…”
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Glucose transport regulation by p210 Bcr–Abl in a chronic myeloid leukaemia model by Bentley, J., Walker, I., McIntosh, E., Whetton, A. D., Owen‐Lynch, P. J., Baldwin, S. A.

“…The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of…”
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Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU‐GM by BROOME, C. S, WHETTON, A. D, MIYAN, J. A

“…Noradrenaline‐ and peptide‐containing nerve fibres project into the bone marrow and terminate in association with stromal cells and within the parenchyma…”
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Homing and mobilization in the stem cell niche by Whetton, Anthony D, Graham, Gerry J

“…All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is this…”
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Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways by Dobbin, E, Graham, C, Freeburn, R W, Unwin, R D, Griffiths, J R, Pierce, A, Whetton, A D, Wheadon, H

“…Objective proteomic analysis offers opportunities for hypothesis generation on molecular events associated with pathogenesis in stem cells. Relative…”
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Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line by KAN, O, BALDWIN, S. A, WHETTON, A. D

“…In the absence of a survival stimulus, the interleukin 3 (IL-3)-dependent IC.DP cell line undergoes a process termed programmed cell death or apoptosis…”
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Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells by EVANS, C. A, OWEN-LYNCH, P, WHETTON, A. D, DIVE, C

“…A chromosomal translocation uniquely associated with chronic myeloid leukemia leads to the formation of a chimeric gene, bcr-abl, on the Philadelphia…”
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Induction of apoptosis--new targets for cancer chemotherapy by Dive, C, Evans, C A, Whetton, A D

“…Many anticancer agents induce an active cell death process, apoptosis, in sensitive tumour cells. Elucidation of molecular mechanisms underlying apoptosis may…”
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Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha by WARK, G, HEYWORTH, C. M, SPOONCER, E, CZAPLEWSKI, L, FRANCIS, J. M, DEXTER, T. M, WHETTON, A. D

“…The clonogenic cells of chronic myeloid leukaemia (CML), unlike normal haemopoietic progenitor cells, are resistant to the growth inhibitory effects of the…”
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Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib by Hamzah, H G, Pierce, A, Stewart, W A, Peter Downes, C, Gray, A, Irvine, A, Spooncer, E, Whetton, A D

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