Search Results - "Whetstone, William D."

Rate and Predictors of Serious Neurologic Causes of Dizziness in the Emergency Department by Navi, Babak B., MD, Kamel, Hooman, MD, Shah, Maulik P., MD, Grossman, Aaron W., MD, PhD, Wong, Christine, MD, Poisson, Sharon N., MD, MAS, Whetstone, William D., MD, Josephson, S. Andrew, MD, Johnston, S. Claiborne, MD, PhD, Kim, Anthony S., MD, MAS

“…Abstract Objective To describe the rate and predictors of central nervous system (CNS) disease in emergency department (ED) patients with dizziness in the…”
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XGBoost, a Machine Learning Method, Predicts Neurological Recovery in Patients with Cervical Spinal Cord Injury by Inoue, Tomoo, Ichikawa, Daisuke, Ueno, Taro, Cheong, Maxwell, Inoue, Takashi, Whetstone, William D, Endo, Toshiki, Nizuma, Kuniyasu, Tominaga, Teiji

“…The accurate prediction of neurological outcomes in patients with cervical spinal cord injury (SCI) is difficult because of heterogeneity in patient…”
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Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome by Chou, Austin, Torres-Espin, Abel, Kyritsis, Nikos, Huie, J Russell, Khatry, Sarah, Funk, Jeremy, Hay, Jennifer, Lofgreen, Andrew, Shah, Rajiv, McCann, Chandler, Pascual, Lisa U, Amorim, Edilberto, Weinstein, Philip R, Manley, Geoffrey T, Dhall, Sanjay S, Pan, Jonathan Z, Bresnahan, Jacqueline C, Beattie, Michael S, Whetstone, William D, Ferguson, Adam R

“…Artificial intelligence and machine learning (AI/ML) is becoming increasingly more accessible to biomedical researchers with significant potential to transform…”
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Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury by Whetstone, William D, Walker, Breset, Trivedi, Alpa, Lee, Sangmi, Noble-Haeusslein, Linda J, Hsu, Jung-Yu C

“…Thrombin-induced secondary injury is mediated through its receptor, protease activated receptor-1 (PAR-1), by "biased agonism." Activated protein C (APC) acts…”
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Blood-spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing by Whetstone, William D., Hsu, Jung-Yu C., Eisenberg, Manuel, Werb, Zena, Noble-Haeusslein, Linda J.

“…Spinal cord injury produces prominent disruption of the blood‐spinal cord barrier. We have defined the blood‐spinal cord barrier breakdown to the protein…”
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Traumatic Injury to the Immature Brain: Inflammation, Oxidative Injury, and Iron-Mediated Damage as Potential Therapeutic Targets by Potts, Mathew B., Koh, Seong-Eun, Whetstone, William D., Walker, Breset A., Yoneyama, Tomoko, Claus, Catherine P., Manvelyan, Hovhannes M., Noble-Haeusslein, Linda J.

“…Traumatic brain injury (TBI) is the leading cause of morbidity and mortality among children and both clinical and experimental data reveal that the immature…”
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Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications by Inoue, Tomoo, Manley, Geoffrey T, Patel, Nihari, Whetstone, William D

“…The optimal mean arterial blood pressure for maintenance of spinal cord perfusion is not known. Our aim was to describe vasopressor usage and examine their…”
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Neurotrauma and Critical Care of the Spine. By Jack Jallo, MD, PhD, and Alexander R. Vaccaro, MD, PhD, MBA. New York: Thieme Medical Publishers, 2018; 225 pp; $179.99 (hardcover) by Whetstone, William D., Sokolove, Peter E.

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Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury by Burke, John F, Yue, John K, Ngwenya, Laura B, Winkler, Ethan A, Talbott, Jason F, Pan, Jonathan Z, Ferguson, Adam R, Beattie, Michael S, Bresnahan, Jacqueline C, Haefeli, Jenny, Whetstone, William D, Suen, Catherine G, Huang, Michael C, Manley, Geoffrey T, Tarapore, Phiroz E, Dhall, Sanjay S

“…Cervical spinal cord injury (SCI) is a devastating condition with very few treatment options. It remains unclear if early surgery correlated with conversion of…”
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Diagnostic blood RNA profiles for human acute spinal cord injury by Kyritsis, Nikos, Torres-Espín, Abel, Schupp, Patrick G, Huie, J Russell, Chou, Austin, Duong-Fernandez, Xuan, Thomas, Leigh H, Tsolinas, Rachel E, Hemmerle, Debra D, Pascual, Lisa U, Singh, Vineeta, Pan, Jonathan Z, Talbott, Jason F, Whetstone, William D, Burke, John F, DiGiorgio, Anthony M, Weinstein, Philip R, Manley, Geoffrey T, Dhall, Sanjay S, Ferguson, Adam R, Oldham, Michael C, Bresnahan, Jacqueline C, Beattie, Michael S

“…Diagnosis of spinal cord injury (SCI) severity at the ultra-acute stage is of great importance for emergency clinical care of patients as well as for potential…”
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The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings by Talbott, Jason F, Whetstone, William D, Readdy, William J, Ferguson, Adam R, Bresnahan, Jacqueline C, Saigal, Rajiv, Hawryluk, Gregory W J, Beattie, Michael S, Mabray, Marc C, Pan, Jonathan Z, Manley, Geoffrey T, Dhall, Sanjay S

“…Previous studies that have evaluated the prognostic value of abnormal changes in signals on T2-weighted MRI scans of an injured spinal cord have focused on the…”
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Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury by Dhall, Sanjay S, Haefeli, Jenny, Talbott, Jason F, Ferguson, Adam R, Readdy, William J, Bresnahan, Jacqueline C, Beattie, Michael S, Pan, Jonathan Z, Manley, Geoffrey T, Whetstone, William D

“…Abstract BACKGROUND While the utilization of neurophysiologic intraoperative monitoring with motor evoked potentials (MEPs) has become widespread in surgery…”
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Correction: Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome by Chou, Austin, Torres-Espin, Abel, Kyritsis, Nikos, Huie, J. Russell, Khatry, Sarah, Funk, Jeremy, Hay, Jennifer, Lofgreen, Andrew, Shah, Rajiv, McCann, Chandler, Pascual, Lisa U, Amorim, Edilberto, Weinstein, Philip R, Manley, Geoffrey T, Dhall, Sanjay S, Pan, Jonathan Z, Bresnahan, Jacqueline C, Beattie, Michael S, Whetstone, William D, Ferguson, Adam R

“…[This corrects the article DOI: 10.1371/journal.pone.0265254.]…”
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Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study by Yue, John K., Hemmerle, Debra D., Winkler, Ethan A., Thomas, Leigh H., Fernandez, Xuan Duong, Kyritsis, Nikolaos, Pan, Jonathan Z., Pascual, Lisa U., Singh, Vineeta, Weinstein, Philip R., Talbott, Jason F., Huie, J. Russell, Ferguson, Adam R., Whetstone, William D., Manley, Geoffrey T., Beattie, Michael S., Bresnahan, Jacqueline C., Mummaneni, Praveen V., Dhall, Sanjay S.

“…We sought to report the safety of implementation of a novel standard of care protocol using spinal cord perfusion pressure (SCPP) maintenance for managing…”
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Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury by Mabray, Marc C, Talbott, Jason F, Whetstone, William D, Dhall, Sanjay S, Phillips, David B, Pan, Jonathan Z, Manley, Geoffrey T, Bresnahan, Jacqueline C, Beattie, Michael S, Haefeli, Jenny, Ferguson, Adam R

“…Literature examining magnetic resonance imaging (MRI) in acute spinal cord injury (SCI) has focused on cervical SCI. Reproducible systems have been developed…”
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Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury by Readdy, William J., Saigal, Rajiv, Whetstone, William D., Mefford, Anthony N., Ferguson, Adam R., Talbott, Jason F., Inoue, Tomoo, Bresnahan, Jacqueline C., Beattie, Michael S., Pan, Jonathan, Manley, Geoffrey T., Dhall, Sanjay S.

“…Abstract BACKGROUND: Increased spinal cord perfusion and blood pressure goals have been recommended for spinal cord injury (SCI). Penetrating SCI is associated…”
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Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome by Readdy, William J, Whetstone, William D, Ferguson, Adam R, Talbott, Jason F, Inoue, Tomoo, Saigal, Rajiv, Bresnahan, Jacqueline C, Beattie, Michael S, Pan, Jonathan Z, Manley, Geoffrey T, Dhall, Sanjay S

“…OBJECT The optimal mean arterial pressure (MAP) for spinal cord perfusion after trauma remains unclear. Although there are published data on MAP goals after…”
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The correlation of neurosurgery motor examinations with ISNCSCI motor examinations in patients with spinal cord injury: a multicenter TRACK-SCI study by Lui, Austin, Bonney, Phillip A, Burke, John, Kanter, John H, Yue, John K, Takegami, Naoki, Tarapore, Phiroz E, Huang, Michael, Mummaneni, Praveen V, Dhall, Sanjay S, Hemmerle, Debra D, Ferguson, Adam R, Torres-Espin, Abel, Duong-Fernandez, Xuan, Lai, Nicole, Saigal, Rajiv, Pan, Jonathan, Singh, Vineeta, Kyritsis, Nikos, Talbott, Jason F, Pascual, Lisa U, Huie, J Russell, Whetstone, William D, Bresnahan, Jacqueline C, Beattie, Michael S, Weinstein, Philip R, Manley, Geoffrey T, O'Banion, Leigh Ann, Kuo, Yu-Hung, Viljoen, Stephanus, Grandhi, Ramesh, Shammassian, Berje H, DiGiorgio, Anthony M

“…The International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) assessment is the gold standard for evaluation of neurological…”
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Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study by Lui, Austin, Park, Christine, Chryssikos, Timothy, Radabaugh, Hannah, Patel, Arati, Aabedi, Alexander A., Ferguson, Adam R., Torres Espin, Abel, Mummaneni, Praveen V., Dhall, Sanjay S., Duong-Fernandez, Xuan, Saigal, Rajiv, Chou, Austin, Pan, Jonathan, Singh, Vineeta, Hemmerle, Debra D., Kyritsis, Nikos, Talbott, Jason F., Pascual, Lisa U., Huie, J. Russell, Whetstone, William D., Bresnahan, Jacqueline C., Beattie, Michael S., Weinstein, Philip R., Manley, Geoffrey T., DiGiorgio, Anthony M.

“…OBJECTIVEVenous thromboembolism (VTE) following traumatic spinal cord injury (SCI) is a significant clinical concern. This study sought to determine the…”
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Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury by Readdy, William J, Saigal, Rajiv, Whetstone, William D, Mefford, Anthony N, Ferguson, Adam R, Talbott, Jason F, Inoue, Tomoo, Bresnahan, Jacqueline C, Beattie, Michael S, Pan, Jonathan, Manley, Geoffrey T, Dhall, Sanjay S

“…Increased spinal cord perfusion and blood pressure goals have been recommended for spinal cord injury (SCI). Penetrating SCI is associated with poor prognosis,…”
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