Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility

Polypropylene mesh materials have been utilized in hernia surgery for over 40 years. However, they are prone to degradation due to the body’s aggressive foreign body reaction, which may cause pain or complications, forcing mesh removal from the patient. To mitigate these complications, gold nanomate...

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Bibliographic Details
Published in:	Journal of materials science. Materials in medicine Vol. 22; no. 12; pp. 2803 - 2812
Main Authors:	Grant, D. N., Benson, J., Cozad, M. J., Whelove, O. E., Bachman, S. L., Ramshaw, B. J., Grant, D. A., Grant, S. A.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-12-2011 Springer Springer Nature B.V
Subjects:	Alkenes - chemistry Amines - chemistry Animals Biocompatible Materials - chemistry Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Calorimetry, Differential Scanning Cell Line Ceramics Chemistry and Materials Science Cobalt - chemistry Composites Cross-Linking Reagents - chemistry Foreign-Body Reaction Glass Gold Gold - chemistry Hernia - therapy Hydrogen Peroxide - chemistry Materials Science Materials Testing Medical sciences Metal Nanoparticles - chemistry Mice Microscopy, Electron, Scanning Nanoparticles Nanotechnology Natural Materials Polymer Sciences Polypropylene Polypropylenes - chemistry Regenerative Medicine/Tissue Engineering Spectroscopy, Fourier Transform Infrared Stress, Mechanical Surface Properties Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Mesh Technology. Biomaterials. Equipments Thin Films Energy Dispersive Spectroscopy Polypropylene Gold Nanoparticles Hernia Repair Polypropylene Mesh Biological properties Gold Nanoparticle Propylene polymer Biocompatibility Olefin polymer Mesh Metal particle Biomedical engineering
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Summary:	Polypropylene mesh materials have been utilized in hernia surgery for over 40 years. However, they are prone to degradation due to the body’s aggressive foreign body reaction, which may cause pain or complications, forcing mesh removal from the patient. To mitigate these complications, gold nanomaterials were attached to polypropylene mesh in order to improve cellular response. Pristine samples of polypropylene mesh were exposed to hydrogen peroxide/cobalt chloride solutions to induce formation of surface carboxyl functional groups. Gold nanoparticles were covalently linked to the mesh. Scanning electron microscopy confirmed the presence of gold nanoparticles. Differential scanning calorimetry and mechanical testing confirmed that the polypropylene did not undergo any significantly detrimental changes in physicochemical properties. A WST-1 cell culture study showed an increase in cellularity on the gold nanoparticle–polypropylene mesh as compared to pristine mesh. This study showed that biocompatibility of polypropylene mesh may be improved via the conjugation of gold nanoparticles.
ISSN:	0957-4530 1573-4838
DOI:	10.1007/s10856-011-4449-6