Search Results - "Whelan, S"

Osteosarcoma, Chondrosarcoma, and Chordoma by Whelan, Jeremy S, Davis, Lara E

“…Osteosarcoma (OS), chondrosarcoma, and chordoma are characterized by multiple challenges to the investigator, clinician, and patient. One consequence of their…”
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Mechanisms of Cell Death in Heart Disease by Konstantinidis, Klitos, Whelan, Russell S, Kitsis, Richard N

“…The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a large portion of deaths worldwide. Genetic and pharmacological…”
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Cell death in the pathogenesis of heart disease: mechanisms and significance by Whelan, Russell S, Kaplinskiy, Vladimir, Kitsis, Richard N

“…Cell death was once viewed as unregulated. It is now clear that at least a portion of cell death is a regulated cell suicide process. This type of death can…”
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Mesenchymal stromal cell derived CCL2 is required for accelerated wound healing by Whelan, Derek S., Caplice, Noel M., Clover, Anthony J. P.

“…Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent…”
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Current questions in bone sarcomas by Strauss, Sandra J, Whelan, Jeremy S

“…PURPOSE OF REVIEWOsteosarcoma and Ewing sarcoma, the most common primary bone tumours in young people, are curable in most patients. However, these tumours…”
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Bax regulates primary necrosis through mitochondrial dynamics by Whelan, Russell S, Konstantinidis, Klitos, Wei, An-Chi, Chen, Yun, Reyna, Denis E, Jha, Saurabh, Yang, Ying, Calvert, John W, Lindsten, Tullia, Thompson, Craig B, Crow, Michael T, Gavathiotis, Evripidis, Dorn, Gerald W. II, O'Rourke, Brian, Kitsis, Richard N

“…The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in…”
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Developmental plasticity, morphological variation and evolvability: a multilevel analysis of morphometric integration in the shape of compound leaves by KLINGENBERG, C. P., DUTTKE, S., WHELAN, S., KIM, M.

“…The structure of compound leaves provides flexibility for morphological change by variation in the shapes, sizes and arrangement of leaflets. Here, we conduct…”
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Corticosterone release in very young siblicidal seabird chicks (Rissa tridactyla) is sensitive to environmental variability and responds rapidly and robustly to external challenges by Benowitz-Fredericks, Z.M., Will, A.P., Pete, S.N., Whelan, S., Kitaysky, A.S

“…•Five-day old siblicidal seabird chicks show no adrenal hyporesponsive period.•Chick baseline corticosterone (CORT) was lower when parents were food…”
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Breeding seabirds increase foraging range in response to an extreme marine heatwave by Osborne, Orla E., O’Hara, Patrick D., Whelan, Shannon, Zandbergen, Paul, Hatch, Scott A., Elliott, Kyle H.

“…Marine heatwaves are increasing in frequency and can disrupt marine ecosystems non-linearly. In this study, we examined the effect of the North Pacific warming…”
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Telomere length correlates with physiological and behavioural responses of a long-lived seabird to an ecologically relevant challenge by Benowitz-Fredericks, Z M, Lacey, L M, Whelan, S, Will, A P, Hatch, S A, Kitaysky, A S

“…Determinants of individual variation in reallocation of limited resources towards self-maintenance versus reproduction are not well known. We tested the…”
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The Life Expectancy of a Child Born in Ireland in the Twenty-First Century by Whelan, S, Naqvi, R

“…Period Life expectancies for the Irish population are projected and published by the Central Statistics Office (CSO) and the United Nations (UN). This article…”
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Tags below three percent of body mass increase nest abandonment by rhinoceros auklets, but handling impacts decline as breeding progresses by Sun, Alice, Whelan, Shannon, Hatch, Scott A., Elliott, Kyle H.

“…Biologging has revealed many of the mysteries surrounding seabird behavior far from land. However, tagging seabirds with biologgers may influence the very…”
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Association between early and current gastro‐intestinal symptoms and co‐morbidities in children and adolescents with Angelman syndrome by Leader, G., Whelan, S., Chonaill, N. N., Coyne, R., Tones, M., Heussler, H., Bellgard, M., Mannion, A.

“…Background Angelman syndrome (AS) is a neurogenetic disorder that causes severe intellectual disability, expressive language deficits, motor impairment,…”
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Young people’s opinions of cancer care in England: the BRIGHTLIGHT cohort by Hughes, Luke, Fern, Lorna A, Whelan, Jeremy S, Taylor, Rachel M, Study Group, BRIGHTLIGHT

“…Objectives The BRIGHTLIGHT cohort study was the national evaluation of cancer services for teenager and young adults (TYA). This was analysis of free-text…”
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A decision impact, decision conflict and economic assessment of routine Oncotype DX testing of 146 women with node-negative or pNImi, ER-positive breast cancer in the UK by Holt, S, Bertelli, G, Humphreys, I, Valentine, W, Durrani, S, Pudney, D, Rolles, M, Moe, M, Khawaja, S, Sharaiha, Y, Brinkworth, E, Whelan, S, Jones, S, Bennett, H, Phillips, C J

“…Background: Tumour gene expression analysis is useful in predicting adjuvant chemotherapy benefit in early breast cancer patients. This study aims to examine…”
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What is the role of routine follow-up for localised limb soft tissue sarcomas? A retrospective analysis of 174 patients by Rothermundt, C, Whelan, J S, Dileo, P, Strauss, S J, Coleman, J, Briggs, T W, Haile, S R, Seddon, B M

“…Background: There are neither prospective data nor agreement on the optimal routine follow-up procedures in patients treated for soft tissue sarcoma of the…”
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A model for occupational stress amongst paediatric and adult critical care staff during COVID-19 pandemic by Feeley, T., ffrench-O’Carroll, R., Tan, M. H., Magner, C., L’Estrange, K., O’Rathallaigh, E., Whelan, S., Lyons, B., O’Connor, E.

“…Purpose The coronavirus 2019 pandemic has placed all intensive care unit (ICU) staff at increased risk of psychological distress. To date, measurement of this…”
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Research priorities for young people with cancer: a UK priority setting partnership with the James Lind Alliance by Aldiss, Susie, Fern, Lorna A, Phillips, Robert S, Callaghan, Amy, Dyker, Karen, Gravestock, Helen, Groszmann, Michael, Hamrang, Leila, Hough, Rachael, McGeachy, Demi, Morgan, Sue, Smith, Sam, Upadhyaya, Sheela, Veitch, Helen, Veitch, Lara, Williamson, Max, Whelan, Jeremy S, Gibson, Faith

“…ObjectivesTo conduct a UK-wide survey of young people who have experienced cancer, carers and professionals, to identify and prioritise research questions to…”
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Survival from high-grade localised extremity osteosarcoma: combined results and prognostic factors from three European Osteosarcoma Intergroup randomised controlled trials by Whelan, J.S., Jinks, R.C., McTiernan, A., Sydes, M.R., Hook, J.M., Trani, L., Uscinska, B., Bramwell, V., Lewis, I.J., Nooij, M.A., van Glabbeke, M., Grimer, R.J., Hogendoorn, P.C.W., Taminiau, A.H.M., Gelderblom, H.

“…Neoadjuvant chemotherapy improves outcome in osteosarcoma. Determination of optimum regimens for survival, toxicity and prognostic factors requires randomised…”
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Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis by Cohen, Jeffrey M, Fagin, Adam P, Hariton, Eduardo, Niska, Joshua R, Pierce, Michael W, Kuriyama, Akira, Whelan, Julia S, Jackson, Jeffrey L, Dimitrakoff, Jordan D

“…Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has been treated with several different interventions with limited success. This meta-analysis aims…”
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