Search Results - "Whelan, Matthew V. X."

A novel high-content screening approach for the elucidation of C. jejuni biofilm composition and integrity by Whelan, Matthew V X, Simpson, Jeremy C, Ó Cróinín, Tadhg

“…Campylobacter jejuni is the leading cause of bacterial gastroenteritis worldwide and the main source of infection is contaminated chicken meat. Although this…”
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SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation by Thorne, Lucy G, Reuschl, Ann‐Kathrin, Zuliani‐Alvarez, Lorena, Whelan, Matthew V X, Turner, Jane, Noursadeghi, Mahdad, Jolly, Clare, Towers, Greg J

“…SARS‐CoV‐2 infection causes broad‐spectrum immunopathological disease, exacerbated by inflammatory co‐morbidities. A better understanding of mechanisms…”
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HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65 by Fink, Douglas L, Cai, James, Whelan, Matthew V X, Monit, Christopher, Maluquer de Motes, Carlos, Towers, Greg J, Sumner, Rebecca P

“…The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB…”
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WQ-3810, a fluoroquinolone with difluoropyridine derivative as the R1 group exerts high potency against quinolone-resistant Campylobacter jejuni by Koide, Kentaro, Kim, Hyun, Whelan, Matthew V X, Belotindos, Lawrence P, Tanomsridachchai, Wimonrat, Changkwanyeun, Ruchirada, Usui, Masaru, Ó Cróinín, Tadhg, Thapa, Jeewan, Nakajima, Chie, Suzuki, Yasuhiko

“…Quinolone-resistant have been increasing worldwide. Quinolones exert their antibacterial activity by inhibiting DNA gyrase, but most of the isolates acquire…”
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Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants by Reuschl, Ann-Kathrin, Thorne, Lucy G., Whelan, Matthew V. X., Ragazzini, Roberta, Furnon, Wilhelm, Cowton, Vanessa M., De Lorenzo, Giuditta, Mesner, Dejan, Turner, Jane L. E., Dowgier, Giulia, Bogoda, Nathasha, Bonfanti, Paola, Palmarini, Massimo, Patel, Arvind H., Jolly, Clare, Towers, Greg J.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted in distinct lineages with enhanced transmissibility called variants of…”
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Relaxation of DNA supercoiling leads to increased invasion of epithelial cells and protein secretion by Campylobacter jejuni by Scanlan, Eoin, Ardill, Laura, Whelan, Matthew V. X., Shortt, Claire, Nally, Jarlath E., Bourke, Billy, Ó Cróinín, Tadhg

“…Summary Invasion of intestinal epithelial cells by Campylobacter jejuni is a critical step during infection of the intestine by this important human pathogen…”
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Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA‐mimic protein and may be involved in the adaptation of Burkholderia cenocepacia by Dennehy, Ruth, Duggan, Niamh, Dignam, Simon, McCormack, Sarah, Dillon, Eugene, Molony, Jessica, Romano, Maria, Hou, Yueran, Ardill, Laura, Whelan, Matthew V. X., Drulis‐Kawa, Zuzanna, Ó'Cróinín, Tadhg, Valvano, Miguel A., Berisio, Rita, McClean, Siobhán

“…Adaptation of opportunistic pathogens to their host environment requires reprogramming of a vast array of genes to facilitate survival in the host…”
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SARS-CoV-2 evolution influences GBP and IFITM sensitivity by Mesner, Dejan, Reuschl, Ann-Kathrin, Whelan, Matthew V X, Bronzovich, Taylor, Haider, Tafhima, Thorne, Lucy G, Ragazzini, Roberta, Bonfanti, Paola, Towers, Greg J, Jolly, Clare

“…SARS-CoV-2 spike requires proteolytic processing for viral entry. A polybasic furin-cleavage site (FCS) in spike, and evolution toward an optimized FCS by…”
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Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni by Whelan, Matthew V. X., Ardill, Laura, Koide, Kentaro, Nakajima, Chie, Suzuki, Yasuhiko, Simpson, Jeremy C., Ó Cróinín, Tadhg

“…The World Health Organization has listed C . jejuni as one of 12 microorganisms on a global priority list for antibiotic resistance due to a rapid increase in…”
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HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells by Reuschl, Ann-Kathrin, Mesner, Dejan, Shivkumar, Maitreyi, Whelan, Matthew V.X., Pallett, Laura J., Guerra-Assunção, José Afonso, Madansein, Rajhmun, Dullabh, Kaylesh J., Sigal, Alex, Thornhill, John P., Herrera, Carolina, Fidler, Sarah, Noursadeghi, Mahdad, Maini, Mala K., Jolly, Clare

“…HIV-1 replicates in CD4+ T cells, leading to AIDS. Determining how HIV-1 shapes its niche to create a permissive environment is central to informing efforts to…”
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Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2 by Thorne, Lucy G., Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Zuliani-Alvarez, Lorena, Polacco, Ben, Pelin, Adrian, Batra, Jyoti, Whelan, Matthew V. X., Hosmillo, Myra, Fossati, Andrea, Ragazzini, Roberta, Jungreis, Irwin, Ummadi, Manisha, Rojc, Ajda, Turner, Jane, Bischof, Marie L., Obernier, Kirsten, Braberg, Hannes, Soucheray, Margaret, Richards, Alicia, Chen, Kuei-Ho, Harjai, Bhavya, Memon, Danish, Hiatt, Joseph, Rosales, Romel, McGovern, Briana L., Jahun, Aminu, Fabius, Jacqueline M., White, Kris, Goodfellow, Ian G., Takeuchi, Yasu, Bonfanti, Paola, Shokat, Kevan, Jura, Natalia, Verba, Klim, Noursadeghi, Mahdad, Beltrao, Pedro, Kellis, Manolis, Swaney, Danielle L., García-Sastre, Adolfo, Jolly, Clare, Towers, Greg J., Krogan, Nevan J.

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Evolution of enhanced innate immune evasion by SARS-CoV-2 by Thorne, Lucy G., Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Zuliani-Alvarez, Lorena, Polacco, Ben, Pelin, Adrian, Batra, Jyoti, Whelan, Matthew V. X., Hosmillo, Myra, Fossati, Andrea, Ragazzini, Roberta, Jungreis, Irwin, Ummadi, Manisha, Rojc, Ajda, Turner, Jane, Bischof, Marie L., Obernier, Kirsten, Braberg, Hannes, Soucheray, Margaret, Richards, Alicia, Chen, Kuei-Ho, Harjai, Bhavya, Memon, Danish, Hiatt, Joseph, Rosales, Romel, McGovern, Briana L., Jahun, Aminu, Fabius, Jacqueline M., White, Kris, Goodfellow, Ian G., Takeuchi, Yasu, Bonfanti, Paola, Shokat, Kevan, Jura, Natalia, Verba, Klim, Noursadeghi, Mahdad, Beltrao, Pedro, Kellis, Manolis, Swaney, Danielle L., García-Sastre, Adolfo, Jolly, Clare, Towers, Greg J., Krogan, Nevan J.

“…The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission 1 , 2 . Although much effort has focused on…”
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HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65 by Fink, Douglas L, Cai, James, Whelan, Matthew V. X, Monit, Christopher, Maluquer de Motes, Carlos, Towers, Greg J, Sumner, Rebecca P

“…Background The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of…”
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