Search Results - "Whelan, D R"

Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response by Monson, E. A., Crosse, K. M., Duan, M., Chen, W., O’Shea, R. D., Wakim, L. M., Carr, J. M., Whelan, D. R., Helbig, K. J.

“…Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events, transient protein sequestration and inter-organelle interactions…”
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Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats by Van Schaik, L., Kettle, C., Green, R., Sievers, W., Hale, M. W., Irving, H. R., Whelan, D. R., Rathner, J. A.

“…The role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory…”
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The effect of estrogen on brown adipose tissue activity in male rats by Sievers, W, Kettle, C, Green, R A, Van Schaik, L, Hale, M W, Irving, H R, Whelan, D R, Rathner, J A

“…Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of…”
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SR-FTIR Coupled with Principal Component Analysis Shows Evidence for the Cellular Bystander Effect by Lipiec, E., Bambery, K. R., Lekki, J., Tobin, M. J., Vogel, C., Whelan, D. R., Wood, B. R., Kwiatek, W. M.

“…Synchrotron radiation-Fourier transform infrared (SR-FTIR) microscopy coupled with multivariate data analysis was used as an independent modality to monitor…”
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Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionated X irradiation in vitro by Hill, B T, Deuchars, K, Hosking, L K, Ling, V, Whelan, R D

“…We observed that in vitro exposure of mammalian tumor cells to fractionated x irradiation results in the expression of drug resistance. The cause of this…”
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Loss of protein kinase C function induces an apoptotic response by WHELAN, R. D. H, PARKER, P. J

“…A correlation has been observed between the dephosphorylation and downregulation of cPKC and the induction of apoptosis. This relationship is shown to be…”
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Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro by SHELLARD, S. A, WHELAN, R. D. H, HILL, B. T

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Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro by HILL, B. T, WHELAN, R. D. H, SHELLARD, S. A, MCCLEAN, S, HOSKING, L. K

“…The in vitro cytotoxic effects of docetaxel (Taxotere; RP56976, NSC688503) proved both time and concentration dependent. Amongst thirteen human cell lines from…”
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An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines by Hosking, L K, Whelan, R D, Shellard, S A, Bedford, P, Hill, B T

“…Glutathione and its associated enzyme activities have been quantitated in a series of human tumour continuous cell lines expressing a range of in vitro…”
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Over-expression of P-glycoprotein and glutathione S-transferase pi in MCF-7 cells selected for vincristine resistance in vitro by Whelan, R D, Waring, C J, Wolf, C R, Hayes, J D, Hosking, L K, Hill, B T

“…This study has provided evidence that exposure of the wild-type MCF-7 human breast carcinoma cell line to the mutagen ethyl methane sulphonate (EMS), followed…”
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Identification of a distinctive P-glycoprotein-mediated resistance phenotype in human ovarian carcinoma cells after their in vitro exposure to fractionated X-irradiation by Hill, B T, Whelan, R D, Hurst, H C, McClean, S

“…Clinical drug resistance is recognized in patients previously treated with radiotherapy and after chemotherapy. In vitro exposure of mammalian tumor cells to…”
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Differential expression of steroid receptors, hsp27, and pS2 in a series of drug resistant human breast tumor cell lines derived following exposure to antitumor drugs or to fractionated X-irradiation by WHELAN, R. D. H, HILL, B. T

“…This study examined whether levels of estrogen receptor (ER), progesterone receptor (PR), and expression of estrogen regulated pS2 and/or heat shock protein…”
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Multiple mechanisms of resistance in a series of human testicular teratoma cell lines selected for increasing resistance to etoposide by Hosking, L K, Whelan, R D, Shellard, S A, Davies, S L, Hickson, I D, Danks, M K, Hill, B T

“…Mechanisms of resistance to VP-16 were monitored in a series of sublines of the human testicular teratoma cell line (SuSa) derived following exposure either to…”
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Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate by HILL, B. T, SHELLARD, S. A, HOSKING, L. K, DEMPKE, W. C. M, FICHTINGER, A. M. J, TAKESHI, S, TONE, T, SCANLON, K. J, WHELAN, R. D. H

“…In vitro exposure of the TR170 ovarian carcinoma cell line to six intermittent 24-h treatments with a 90% inhibitory concentration of cisplatin (CDDP) (0.15…”
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Establishment and characterisation of three new human ovarian carcinoma cell lines and initial evaluation of their potential in experimental chemotherapy studies by Hill, B T, Whelan, R D, Gibby, E M, Sheer, D, Hosking, L K, Shellard, S A, Rupniak, H T

“…Three new human cell lines have been established from biopsy specimens of ovarian cystadenocarcinomas: line JA-1 was derived from a primary "solid" tumour from…”
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Evaluation of S9788 as a potential modulator of drug resistance against human tumour sublines expressing differing resistance mechanisms in vitro by Hill, B T, van der Graaf, W T, Hosking, L K, de Vries, E G, Mulder, N H, Whelan, R D

“…Significant activity has been identified using S9788, a triazineaminopiperidine derivative, as a new modulator of multi-drug resistance against a series of…”
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The effects of age on total DNA and cell number in the mouse brain by Franks, L M, Wilson, P D, Whelan, R D

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Differential expression of collateral sensitivity or resistance to cisplatin in human bladder carcinoma cell lines pre-exposed in vitro to either X-irradiation or cisplatin by Bedford, P, Shellard, S A, Walker, M C, Whelan, R D, Masters, J R, Hill, B T

“…Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the…”
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Spirogermanium--a novel antitumour agent expressing a lack of cross-resistance in vitro with a range of 'standard' antitumour drugs by Hill, B T, Whelan, R D

“…We have used a series of drug resistant continuous tumour cell lines of murine, hamster or human origin, to screen in vitro for new drugs effective at…”
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Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes by Hansra, G, Garcia-Paramio, P, Prevostel, C, Whelan, R D, Bornancin, F, Parker, P J

“…The generation of antisera specific for the priming phosphorylation sites on protein kinase Calpha (PKCalpha) has permitted analysis of the dephosphorylation…”
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