Search Results - "Whelan, Adam O"

Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles by Whelan, Adam O, Flick-Smith, Helen C, Homan, Jane, Shen, Zu T, Carpenter, Zoe, Khoshkenar, Payam, Abraham, Ambily, Walker, Nicola J, Levitz, Stuart M, Ostroff, Gary R, Oyston, Petra C F

“…Francisella tularensis is an intracellular pathogen causing the disease tularemia, and an organism of concern to biodefence. There is no licensed vaccine…”
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Development of a Skin Test for Bovine Tuberculosis for Differentiating Infected from Vaccinated Animals by Whelan, Adam O, Clifford, Derek, Upadhyay, Bhagwati, Breadon, Eleanor L, McNair, James, Hewinson, Glyn R, Vordermeier, Martin H

“…The tuberculin skin test has been used for the diagnosis of bovine and human tuberculosis (TB) for over a hundred years. However, the specificity of the test…”
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Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle by Dean, Gillian S, Clifford, Derek, Whelan, Adam O, Tchilian, Elma Z, Beverley, Peter C L, Salguero, Francisco J, Xing, Zhou, Vordermeier, Hans M, Villarreal-Ramos, Bernardo

“…The incidence of bovine tuberculosis (bTB) in the GB has been increasing since the 1980s. Immunisation, alongside current control measures, has been proposed…”
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Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers by Aranday-Cortes, Elihu, Hogarth, Philip J, Kaveh, Daryan A, Whelan, Adam O, Villarreal-Ramos, Bernardo, Lalvani, Ajit, Vordermeier, H Martin

“…Bovine tuberculosis (bTb) remains a major and economically important disease of livestock. Improved ante-mortem diagnostic tools would help to underpin novel…”
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Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination by Maggioli, Mayara F, Palmer, Mitchell V, Thacker, Tyler C, Vordermeier, Hans Martin, McGill, Jodi L, Whelan, Adam O, Larsen, Michelle H, Jacobs, Jr, William R, Waters, W Ray

“…Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB);…”
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An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia by Wren, Brendan W., Prior, Joann L., Atkins, Timothy P., Denman, Carmen, Moule, Madeleine G., Jenner, Dominic C., Whelan, Adam O., Davies, Carwyn H., Nelson, M., Marshall, Laura E., Cuccui, Jon

“…There is a requirement for an efficacious vaccine to protect people against infection from Francisella tularensis, the etiological agent of tularemia. The…”
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Evaluation of Alternative Doxycycline Antibiotic Regimes in an Inhalational Murine Model of Q Fever by Clay, Kate A, Hartley, M Gill, Whelan, Adam O, Bailey, Mark S, Norville, Isobel H

“…The timing of the initiation of antibiotic treatment has been shown to impact the clinical outcome of many bacterial infections, including Q fever. Delayed,…”
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In Vitro Activity of Novel Topoisomerase Inhibitors against Francisella tularensis and Burkholderia pseudomallei by Whelan, Adam O, Cooper, Ian, Ooi, Nicola, Orr, David, Blades, Kevin, Kirkham, James, Lyons, Amanda, Barnes, Kay B, Richards, Mark I, Salisbury, Anne-Marie, Craighead, Mark, Harding, Sarah V

“…Antimicrobial resistance is a global issue, and the investigation of alternative therapies that are not traditional antibiotics are warranted. Novel bacterial…”
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The duration of antigen-stimulation significantly alters the diversity of multifunctional CD4 T cells measured by intracellular cytokine staining by Kaveh, Daryan A, Whelan, Adam O, Hogarth, Philip J

“…The assessment of antigen-specific T cell responses by intracellular cytokine staining (ICS) has become a routine technique in studies of vaccination and…”
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Correlation of ESAT-6-Specific Gamma Interferon Production with Pathology in Cattle following Mycobacterium bovis BCG Vaccination against Experimental Bovine Tuberculosis by VORDERMEIER, H. Martin, CHAMBERS, Mark A, COCKLE, Paul J, WHELAN, Adam O, SIMMONS, Jennifer, HEWINSON, R. Glyn

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Methodology and preliminary results of a systematic literature review of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis by Downs, Sara H., Parry, Jessica E., Upton, Paul A., Broughan, Jennifer M., Goodchild, Anthony V., Nuñez-Garcia, Javier, Greiner, Matthias, Abernethy, Darrell A., Cameron, Angus R., Cook, Alasdair J., de la Rua-Domenech, Ricardo, Gunn, Jane, Pritchard, Elizabeth, Rhodes, Shelley, Rolfe, Simon, Sharp, Michael, Vordermeier, H. Martin, Watson, Eamon, Welsh, Michael, Whelan, Adam O., Woolliams, John A., More, Simon J., Clifton-Hadley, Richard S.

“…•1% of studies identified in electronic databases had eligible diagnostic test data.•Electronic indexing for diagnostic test performance data was…”
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Revisiting Host Preference in the Mycobacterium tuberculosis Complex: Experimental Infection Shows M. tuberculosis H37Rv to Be Avirulent in Cattle by Whelan, Adam O, Coad, Michael, Cockle, Paul J, Hewinson, Glyn, Vordermeier, Martin, Gordon, Stephen V

“…Experiments in the late 19th century sought to define the host specificity of the causative agents of tuberculosis in mammals. Mycobacterium tuberculosis, the…”
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RNA-Seq Transcriptome Analysis of Peripheral Blood From Cattle Infected With Mycobacterium bovis Across an Experimental Time Course by McLoughlin, Kirsten E., Correia, Carolina N., Browne, John A., Magee, David A., Nalpas, Nicolas C., Rue-Albrecht, Kevin, Whelan, Adam O., Villarreal-Ramos, Bernardo, Vordermeier, H. Martin, Gormley, Eamonn, Gordon, Stephen V., MacHugh, David E.

“…Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis , is a major endemic disease…”
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Performance of the Enferplex TB Assay with Cattle in Great Britain and Assessment of Its Suitability as a Test To Distinguish Infected and Vaccinated Animals by Whelan, Clare, Whelan, Adam O, Shuralev, Eduard, Kwok, Hang Fai, Hewinson, Glyn, Clarke, John, Vordermeier, H Martin

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Use of Antigen-Specific Interleukin-2 To Differentiate between Cattle Vaccinated with Mycobacterium bovis BCG and Cattle Infected with M. bovis by Rhodes, Shelley G, McKinna, Lucy C, Steinbach, Sabine, Dean, Gilly S, Villarreal-Ramos, Bernardo, Whelan, Adam O, Pirson, C, Jones, Gareth J, Clifford, Derek, Vordermeier, H Martin

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Bovine tuberculosis: Effect of the tuberculin skin test on in vitro interferon gamma responses by Schiller, Irene, Vordermeier, H. Martin, Waters, W. Ray, Whelan, Adam O., Coad, Michael, Gormley, Eamonn, Buddle, Bryce M., Palmer, Mitchell, Thacker, Tyler, McNair, Jim, Welsh, Michael, Hewinson, R. Glyn, Oesch, Bruno

“…Bovine tuberculosis (bTB) is a disease of zoonotic and economic importance. In many countries, control is based on test and slaughter policies and/or abattoir…”
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Association of Tuberculin-Boosted Antibody Responses with Pathology and Cell-Mediated Immunity in Cattle Vaccinated with Mycobacterium bovis BCG and Infected with M. bovis by LYASHCHENKO, Konstantin, WHELAN, Adam O, GREENWALD, Rena, POLLOCK, John M, ANDERSEN, Peter, HEWINSON, R. Glyn, VORDERMEIER, H. Martin

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Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9 by Chambers, Mark A., Whelan, Adam O., Spallek, Ralf, Singh, Mahavir, Coddeville, Bernadette, Guerardel, Yann, Elass, Elisabeth

“…► M. bovis antigen MPB83 induced expression of TNF-α and MMP-9 by macrophages. ► MPB83 lipopeptide was more potent than glycosylated secreted MPB83 protein. ►…”
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Minimum Infective Dose of Mycobacterium bovis in Cattle by Dean, Gillian S, Rhodes, Shelley G, Coad, Michael, Whelan, Adam O, Cockle, Paul J, Clifford, Derek J, Hewinson, R. Glyn, Vordermeier, H. Martin

“…The aim of this work was to determine the minimum infective dose of Mycobacterium bovis necessary to stimulate specific immune responses and generate pathology…”
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Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland by Nuñez-Garcia, Javier, Downs, Sara H., Parry, Jessica E., Abernethy, Darrell A., Broughan, Jennifer M., Cameron, Angus R., Cook, Alasdair J., de la Rua-Domenech, Ricardo, Goodchild, Anthony V., Gunn, Jane, More, Simon J., Rhodes, Shelley, Rolfe, Simon, Sharp, Michael, Upton, Paul A., Vordermeier, H. Martin, Watson, Eamon, Welsh, Michael, Whelan, Adam O., Woolliams, John A., Clifton-Hadley, Richard S., Greiner, Matthias

“…•First comparison of different bovine tuberculosis tests estimated by meta-analyses.•Sensitivity estimate of single comparative cervical tuberculin test…”
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