Search Results - "Wheelock, Craig E"

Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine by Wheelock, Åsa M, Wheelock, Craig E

“…Respiratory diseases are multifactorial heterogeneous diseases that have proved recalcitrant to understanding using focused molecular techniques. This trend…”
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MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines by Burla, Bo, Arita, Makoto, Arita, Masanori, Bendt, Anne K, Cazenave-Gassiot, Amaury, Dennis, Edward A, Ekroos, Kim, Han, Xianlin, Ikeda, Kazutaka, Liebisch, Gerhard, Lin, Michelle K, Loh, Tze Ping, Meikle, Peter J, Orešič, Matej, Quehenberger, Oswald, Shevchenko, Andrej, Torta, Federico, Wakelam, Michael J O, Wheelock, Craig E, Wenk, Markus R

“…Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in…”
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Correlation-Based Deconvolution (CorrDec) To Generate High-Quality MS2 Spectra from Data-Independent Acquisition in Multisample Studies by Tada, Ipputa, Chaleckis, Romanas, Tsugawa, Hiroshi, Meister, Isabel, Zhang, Pei, Lazarinis, Nikolaos, Dahlén, Barbro, Wheelock, Craig E, Arita, Masanori

“…Data-independent acquisition mass spectrometry (DIA-MS) is essential for information-rich spectral annotations in untargeted metabolomics. However, the…”
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Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes by Carlström, Karl E., Ewing, Ewoud, Granqvist, Mathias, Gyllenberg, Alexandra, Aeinehband, Shahin, Enoksson, Sara Lind, Checa, Antonio, Badam, Tejaswi V. S., Huang, Jesse, Gomez-Cabrero, David, Gustafsson, Mika, Al Nimer, Faiez, Wheelock, Craig E., Kockum, Ingrid, Olsson, Tomas, Jagodic, Maja, Piehl, Fredrik

“…Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox…”
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Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis by Artiach, Gonzalo, Carracedo, Miguel, Plunde, Oscar, Wheelock, Craig E., Thul, Silke, Sjövall, Peter, Franco-Cereceda, Anders, Laguna-Fernandez, Andres, Arnardottir, Hildur, Bäck, Magnus

“…BACKGROUND:Aortic valve stenosis (AVS), which is the most common valvular heart disease, causes a progressive narrowing of the aortic valve as a consequence of…”
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Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma by Kachroo, Priyadarshini, Stewart, Isobel D., Kelly, Rachel S., Stav, Meryl, Mendez, Kevin, Dahlin, Amber, Soeteman, Djøra I., Chu, Su H., Huang, Mengna, Cote, Margaret, Knihtilä, Hanna M., Lee-Sarwar, Kathleen, McGeachie, Michael, Wang, Alberta, Wu, Ann Chen, Virkud, Yamini, Zhang, Pei, Wareham, Nicholas J., Karlson, Elizabeth W., Wheelock, Craig E., Clish, Clary, Weiss, Scott T., Langenberg, Claudia, Lasky-Su, Jessica A.

“…The application of large-scale metabolomic profiling provides new opportunities for realizing the potential of omics-based precision medicine for asthma. By…”
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ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages by Laguna-Fernandez, Andres, Checa, Antonio, Carracedo, Miguel, Artiach, Gonzalo, Petri, Marcelo H, Baumgartner, Roland, Forteza, Maria J, Jiang, Xintong, Andonova, Teodora, Walker, Mary E, Dalli, Jesmond, Arnardottir, Hildur, Gisterå, Anton, Thul, Silke, Wheelock, Craig E, Paulsson-Berne, Gabrielle, Ketelhuth, Daniel F.J, Hansson, Göran K, Bäck, Magnus

“…BACKGROUND:In addition to enhanced proinflammatory signaling, impaired resolution of vascular inflammation plays a key role in atherosclerosis. Proresolving…”
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Dendritic cell reprogramming by endogenously produced lactic acid by Nasi, Aikaterini, Fekete, Tünde, Krishnamurthy, Akilan, Snowden, Stuart, Rajnavölgyi, Eva, Catrina, Anca I, Wheelock, Craig E, Vivar, Nancy, Rethi, Bence

“…The demand for controlling T cell responses via dendritic cell (DC) vaccines initiated a quest for reliable and feasible DC modulatory strategies that would…”
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High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology by Meister, Isabel, Zhang, Pei, Sinha, Anirban, Sköld, C. Magnus, Wheelock, Åsa M, Izumi, Takashi, Chaleckis, Romanas, Wheelock, Craig E

“…Urine is a noninvasive biofluid that is rich in polar metabolites and well suited for metabolomic epidemiology. However, because of individual variability in…”
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Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip by Abdalkader, Rodi, Chaleckis, Romanas, Wheelock, Craig E., Kamei, Ken-ichiro

“…The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible…”
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Application of 'omics technologies to biomarker discovery in inflammatory lung diseases by WHEELOCK, Craig E, GOSS, Victoria M, CHAIBOONCHOE, Amphun, AHMED, Hassan, BALLEREAU, Stéphane, ROSSIOS, Christos, KIAN FAN CHUNG, MONTUSCHI, Paolo, FOWLER, Stephen J, ADCOCK, Ian M, POSTLE, Anthony D, DAHLEN, Sven-Erik, BALGOMA, David, ROWE, Anthony, STERK, Peter J, AUFFRAY, Charles, DJUKANOVIC, Ratko, NICHOLAS, Ben, BRANDSMA, Joost, SKIPP, Paul J, SNOWDEN, Stuart, BURG, Dominic, D'AMICO, Arnaldo, HORVATH, Ildiko

“…Inflammatory lung diseases are highly complex in respect of pathogenesis and relationships between inflammation, clinical disease and response to treatment…”
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Untargeted LC-MS Metabolomics for the Analysis of Micro-scaled Extracellular Metabolites from Hepatocytes by ABDALKADER, Rodi, CHALECKIS, Romanas, MEISTER, Isabel, ZHANG, Pei, WHEELOCK, Craig E., KAMEI, Ken-ichiro

“…Metabolome analysis in micro physiological models is a challenge due to the low volume of the cell culture medium (CCM). Here, we report a LC-MS-based…”
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Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery by Chung, Ming Kei, Rappaport, Stephen M, Wheelock, Craig E, Nguyen, Vy Kim, van der Meer, Thomas P, Miller, Gary W, Vermeulen, Roel, Patel, Chirag J

“…Recent developments in technologies have offered opportunities to measure the exposome with unprecedented accuracy and scale. However, because most…”
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The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability by Daskalaki, Evangelia, Pillon, Nicolas J., Krook, Anna, Wheelock, Craig E., Checa, Antonio

“…The application of metabolomics to investigating the cell secretome has garnered popularity owing to the method’s large-scale data output, biochemical insight,…”
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Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD by Naz, Shama, Kolmert, Johan, Yang, Mingxing, Reinke, Stacey N, Kamleh, Muhammad Anas, Snowden, Stuart, Heyder, Tina, Levänen, Bettina, Erle, David J, Sköld, C Magnus, Wheelock, Åsa M, Wheelock, Craig E

“…Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to…”
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Kynurenine aminotransferase activity of Aro8/Aro9 engage tryptophan degradation by producing kynurenic acid in Saccharomyces cerevisiae by Ohashi, Kazuto, Chaleckis, Romanas, Takaine, Masak, Wheelock, Craig E., Yoshida, Satoshi

“…Kynurenic acid (KA) is a tryptophan (Trp) metabolite that is synthesised in a branch of kynurenine (KYN) pathway. KYN aminotransferase (KAT) catalyses…”
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Network analysis in the investigation of chronic respiratory diseases. From basics to application by Diez, Diego, Agustí, Alvar, Wheelock, Craig E

“…Chronic respiratory diseases are complex multifactorial disorders whose pathogenesis depends on the interplay between host and environmental factors. To fully…”
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Metabolomics-based search for lung cancer markers among patients with different smoking status by Klupczynska-Gabryszak, Agnieszka, Daskalaki, Evangelia, Wheelock, Craig E., Kasprzyk, Mariusz, Dyszkiewicz, Wojciech, Grabicki, Marcin, Brajer-Luftmann, Beata, Pawlak, Magdalena, Kokot, Zenon J., Matysiak, Jan

“…Tobacco smoking is the main etiological factor of lung cancer (LC), which can also cause metabolome disruption. This study aimed to investigate whether the…”
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Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor by Lazarinis, Nikolaos, Bood, Johan, Gomez, Cristina, Kolmert, Johan, Lantz, Ann-Sofie, Gyllfors, Pär, Davis, Andy, Wheelock, Craig E., Dahlén, Sven-Erik, Dahlén, Barbro

“…Leukotriene (LT) E4 is the final active metabolite among the cysteinyl leukotrienes (CysLTs). Animal studies have identified a distinct LTE4 receptor,…”
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Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration by Esser, Julia, BS, Gehrmann, Ulf, MS, D'Alexandri, Fabio Luiz, PhD, Hidalgo-Estévez, Alicia M., PhD, Wheelock, Craig E., PhD, Scheynius, Annika, PhD, Gabrielsson, Susanne, PhD, Rådmark, Olof, PhD

“…Background Leukotrienes (LTs) are potent proinflammatory lipid mediators with key roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles…”
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