Search Results - "Wheeler, P. D."

Equine Endothelial Cells Show Pro-Angiogenic Behaviours in Response to Fibroblast Growth Factor 2 but Not Vascular Endothelial Growth Factor A by Finding, Elizabeth J T, Faulkner, Ashton, Nash, Lilly, Wheeler-Jones, Caroline P D

“…Understanding the factors which control endothelial cell (EC) function and angiogenesis is crucial for developing the horse as a disease model, but equine ECs…”
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N‐acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: The role of l‐cysteine and hydrogen sulphide by Bourne, Lucie E., Patel, Jessal J., Davies, Bethan K., Neven, Ellen, Verhulst, Anja, D'Haese, Patrick C., Wheeler‐Jones, Caroline P. D., Orriss, Isabel R.

“…Arterial medial calcification (AMC) is the deposition of calcium phosphate in the arteries. AMC is widely thought to share similarities with physiological bone…”
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Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells by Garonna, Elena, Botham, Kathleen M, Birdsey, Graeme M, Randi, Anna M, Gonzalez-Perez, Ruben R, Wheeler-Jones, Caroline P D

“…The adipocyte-derived hormone leptin influences the behaviour of a wide range of cell types and is now recognised as a pro-angiogenic and pro-inflammatory…”
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Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells by Garonna, Elena, Botham, Kathleen M, Birdsey, Graeme M, Randi, Anna M, Gonzalez-Perez, Ruben R, Wheeler-Jones, Caroline P. D

“…Quantitative data are in S2 File, subfolder Fig 2C, “densitometry results”; this file includes summary-level data for this experiment rather than…”
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The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1 by Lawson, Jack S, Liu, Hui-Hsuan, Syme, Harriet M, Purcell, Robert, Wheeler-Jones, Caroline P D, Elliott, Jonathan

“…Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation…”
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The Immunomodulatory Effects of Statins on Macrophages by Sheridan, Alanah, Wheeler-Jones, Caroline P. D., Gage, Matthew C.

“…Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors used worldwide to manage dyslipidaemia and thus limit the development of…”
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Adverse Childhood Experiences and Health and Wellness Outcomes among Black Men Who Have Sex with Men by Ports, K. A., Lee, R. D., Raiford, J., Spikes, P., Manago, C., Wheeler, D. P.

“…Black men who have sex with men (BMSM) are a population at the intersection of two minority statuses—racial minority and sexual minority. Membership in either…”
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Endoglin (CD105) is not a specific selection marker for endothelial cells in human islets of Langerhans by Wheeler-Jones, C. P. D., Clarkin, C. E., Farrar, C. E., Dhadda, P., Chagastelles, P., Nardi, N., Jones, P. M.

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Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor β1 by Lawson, J S, Syme, H M, Wheeler-Jones, C P D, Elliott, J

“…Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell…”
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Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid by Graham, V. S., Lawson, C., Wheeler-Jones, C. P. D., Perona, J. S., Ruiz-Gutierrez, V., Botham, K. M.

“…Purpose Current evidence suggests that consumption of virgin olive oil (VOO) helps to protect against the development of atherosclerosis and that minor…”
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C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells by Rautureau, Y, Gowers, I, Wheeler-Jones, C P D, Baxter, G F

“…In vascular smooth muscle cells, relaxant actions of guanosine--3',5'-cyclic monophosphate (cGMP) are well recognized, but there is increasing evidence that…”
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Suppression of nuclear factor-κB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles by De Pascale, Clara, Graham, Valerie, Fowkes, Robert C, Wheeler-Jones, Caroline P.D, Botham, Kathleen M

“…Current evidence indicates that chylomicron remnants (CMR) induce macrophage foam cell formation, an early event in atherosclerosis. Inflammation also plays a…”
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Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis by Vara, Dina, Watt, Joanna M, Fortunato, Tiago M, Mellor, Harry, Burgess, Matthew, Wicks, Kate, Mace, Kimberly, Reeksting, Shaun, Lubben, Anneke, Wheeler-Jones, Caroline P D, Pula, Giordano

“…Deoxyribose-1-phosphate (dRP) is a proangiogenic paracrine stimulus released by cancer cells, platelets, and macrophages and acting on endothelial cells. The…”
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2‘-O-Aminopropyl Ribonucleotides:  A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides by Griffey, Richard H., Monia, Brett P., Cummins, Lendall L., Freier, Susan, Greig, Michael J., Guinosso, Charles J., Lesnik, Elena, Manalili, Sherilynn M., Mohan, Venkatraman, Owens, Steven, Ross, Bruce R., Sasmor, Henri, Wancewicz, Ed, Weiler, Kurt, Wheeler, Patrick D., Cook, P. Dan

“…Oligonucleotides containing 2‘-O-aminopropyl-substituted RNA have been synthesized. The 2‘-O-(aminopropyl)adenosine (APA), 2‘-O-(aminopropyl)cytidine (APC),…”
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Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms by Patel, Jessal J., Zhu, Dongxing, Opdebeeck, Britt, D'Haese, Patrick, Millán, José L., Bourne, Lucie E., Wheeler‐Jones, Caroline P.D., Arnett, Timothy R., MacRae, Vicky E., Orriss, Isabel R.

“…Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralization and has been associated with the…”
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A Specific Mechanomodulatory Role for p38 MAPK in Embryonic Joint Articular Surface Cell MEK-ERK Pathway Regulation by Lewthwaite, Jo C., Bastow, Edward R., Lamb, Katherine J., Blenis, John, Wheeler-Jones, Caroline P.D., Pitsillides, Andrew A.

“…Mechanisms regulating cell behavior and extracellular matrix composition in response to mechanical stimuli remain unresolved. Our previous studies have…”
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Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts by Tivers, M.S., Lipscomb, V.J., Smith, K.C., Wheeler-Jones, C.P.D., House, A.K.

“…•Lipopolysaccharide (LPS) was detected in portal blood and was increased in dogs with congenital portosystemic shunts (CPSS).•Hepatic toll-like receptor (TLR)…”
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Geochemical signature of historical mining: Fowey Estuary, Cornwall, UK by Pirrie, Duncan, Power, Matthew R, Wheeler, Paul D, Cundy, Andy, Bridges, Colin, Davey, Graham

“…Geochemical analyses of intertidal sediments from the northern part of the Fowey Estuary, Cornwall, UK, reveal a clear pulse in Sn concentration in sediments…”
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Selective Activation of the MEK-ERK Pathway Is Regulated by Mechanical Stimuli in Forming Joints and Promotes Pericellular Matrix Formation by Bastow, Edward R., Lamb, Katherine J., Lewthwaite, Jo C., Osborne, Anne C., Kavanagh, Emma, Wheeler-Jones, Caroline P.D., Pitsillides, Andrew A.

“…It is well established that local modification of extracellular matrix (ECM) hyaluronan composition is vital in the regulation of cell behavior. Indeed, the…”
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Highly homologous Mycobacterium tuberculosis chaperonin 60 proteins with differential CD14 dependencies stimulate cytokine production by human monocytes through cooperative activation of p38 and ERK1/2 mitogen-activated protein kinases by Lewthwaite, Jo C., Clarkin, Claire E., Coates, Anthony R.M., Poole, Stephen, Lawrence, Rachel A., Wheeler-Jones, Caroline P.D., Pitsillides, Andrew A., Singh, Mahavir, Henderson, Brian

“…Tuberculosis is a chronic inflammatory and destructive disease caused by infection with Mycobacterium tuberculosis. We have previously shown that the…”
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