Search Results - "Wheeler, Matthew T"

Time trajectories in the transcriptomic response to exercise - a meta-analysis by Amar, David, Lindholm, Malene E., Norrbom, Jessica, Wheeler, Matthew T., Rivas, Manuel A., Ashley, Euan A.

“…Exercise training prevents multiple diseases, yet the molecular mechanisms that drive exercise adaptation are incompletely understood. To address this, we…”
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Cost-Effectiveness of Preparticipation Screening for Prevention of Sudden Cardiac Death in Young Athletes by WHEELER, Matthew T, HEIDENREICH, Paul A, FROELICHER, Victor F, HLATKY, Mark A, ASHLEY, Euan A

“…Inclusion of 12-lead electrocardiography (ECG) in preparticipation screening of young athletes is controversial because of concerns about cost-effectiveness…”
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Clinical Interpretation and Implications of Whole-Genome Sequencing by Dewey, Frederick E, Grove, Megan E, Pan, Cuiping, Goldstein, Benjamin A, Bernstein, Jonathan A, Chaib, Hassan, Merker, Jason D, Goldfeder, Rachel L, Enns, Gregory M, David, Sean P, Pakdaman, Neda, Ormond, Kelly E, Caleshu, Colleen, Kingham, Kerry, Klein, Teri E, Whirl-Carrillo, Michelle, Sakamoto, Kenneth, Wheeler, Matthew T, Butte, Atul J, Ford, James M, Boxer, Linda, Ioannidis, John P. A, Yeung, Alan C, Altman, Russ B, Assimes, Themistocles L, Snyder, Michael, Ashley, Euan A, Quertermous, Thomas

“…IMPORTANCE Whole-genome sequencing (WGS) is increasingly applied in clinical medicine and is expected to uncover clinically significant findings regardless of…”
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Effect of beta‐blocker therapy on the response to mavacamten in patients with symptomatic obstructive hypertrophic cardiomyopathy by Wheeler, Matthew T., Jacoby, Daniel, Elliott, Perry M., Saberi, Sara, Hegde, Sheila M., Lakdawala, Neal K., Myers, Jonathan, Sehnert, Amy J., Edelberg, Jay M., Li, Wanying, Olivotto, Iacopo

“…Aims In the EXPLORER‐HCM trial, mavacamten improved exercise capacity and symptoms in patients with obstructive hypertrophic cardiomyopathy (oHCM). Mavacamten…”
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Challenges in the clinical application of whole-genome sequencing by Ormond, Kelly E, MSc, Wheeler, Matthew T, MD, Hudgins, Louanne, Prof, Klein, Teri E, PhD, Butte, Atul J, MD, Altman, Russ B, Prof, Ashley, Euan A, MRCP, Greely, Henry T, Prof

“…Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases,…”
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Clinical assessment incorporating a personal genome by Ashley, Euan A, Dr, Butte, Atul J, MD, Wheeler, Matthew T, MD, Chen, Rong, PhD, Klein, Teri E, PhD, Dewey, Frederick E, MD, Dudley, Joel T, Ormond, Kelly E, MSc, Pavlovic, Aleksandra, BS, Morgan, Alexander A, MS, Pushkarev, Dmitry, Neff, Norma F, PhD, Hudgins, Louanne, Prof, Gong, Li, PhD, Hodges, Laura M, PhD, Berlin, Dorit S, PhD, Thorn, Caroline F, PhD, Sangkuhl, Katrin, PhD, Hebert, Joan M, MA, Woon, Mark, BSE, Sagreiya, Hersh, Whaley, Ryan, BS, Knowles, Joshua W, MD, Chou, Michael F, PhD, Thakuria, Joseph V, MD, Rosenbaum, Abraham M, PhD, Zaranek, Alexander Wait, PhD, Church, George M, PhD, Greely, Henry T, Prof, Quake, Stephen R, PhD, Altman, Russ B, Prof

“…Summary Background The cost of genomic information has fallen steeply, but the clinical translation of genetic risk estimates remains unclear. We aimed to…”
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Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy by Kahn-Kirby, Amanda H, Amagata, Akiko, Maeder, Celine I, Mei, Janet J, Sideris, Steve, Kosaka, Yuko, Hinman, Andrew, Malone, Stephanie A, Bruegger, Joel J, Wang, Leslie, Kim, Virna, Shrader, William D, Hoff, Kevin G, Latham, Joey C, Ashley, Euan A, Wheeler, Matthew T, Bertini, Enrico, Carrozzo, Rosalba, Martinelli, Diego, Dionisi-Vici, Carlo, Chapman, Kimberly A, Enns, Gregory M, Gahl, William, Wolfe, Lynne, Saneto, Russell P, Johnson, Simon C, Trimmer, Jeffrey K, Klein, Matthew B, Holst, Charles R

“…Mitochondrial disease is a family of genetic disorders characterized by defects in the generation and regulation of energy. Epilepsy is a common symptom of…”
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Medical implications of technical accuracy in genome sequencing by Goldfeder, Rachel L, Priest, James R, Zook, Justin M, Grove, Megan E, Waggott, Daryl, Wheeler, Matthew T, Salit, Marc, Ashley, Euan A

“…As whole exome sequencing (WES) and whole genome sequencing (WGS) transition from research tools to clinical diagnostic tests, it is increasingly critical for…”
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Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics by Bonder, Marc Jan, Smail, Craig, Gloudemans, Michael J., Frésard, Laure, Jakubosky, David, D’Antonio, Matteo, Li, Xin, Ferraro, Nicole M., Carcamo-Orive, Ivan, Mirauta, Bogdan, Seaton, Daniel D., Cai, Na, Vakili, Dara, Horta, Danilo, Zhao, Chunli, Zastrow, Diane B., Bonner, Devon E., Wheeler, Matthew T., Kilpinen, Helena, Knowles, Joshua W., Smith, Erin N., Frazer, Kelly A., Montgomery, Stephen B., Stegle, Oliver

“…Induced pluripotent stem cells (iPSCs) are an established cellular system to study the impact of genetic variants in derived cell types and developmental…”
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Mavacamten for Obstructive Hypertrophic Cardiomyopathy: Rationale for Clinically Guided Dose Titration to Optimize Individual Response by Owens, Anjali T, Desai, Milind, Wheeler, Matthew T, Rodonski, Anna, Merali, Samira, Sehnert, Amy J, Saberi, Sara

“…Mavacamten is the first and only cardiac myosin inhibitor approved in 5 continents for the treatment of adults with symptomatic New York Heart Association…”
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Physical Activity and Other Health Behaviors in Adults With Hypertrophic Cardiomyopathy by Reineck, Elizabeth, MD, Rolston, Brice, BA, Bragg-Gresham, Jennifer L., MS, Salberg, Lisa, Baty, Linda, RN, Kumar, Suwen, MD, Wheeler, Matthew T., MD, PhD, Ashley, Euan, MRCP, DPhil, Saberi, Sara, MD, Day, Sharlene M., MD

“…The clinical expression of hypertrophic cardiomyopathy (HC) is undoubtedly influenced by modifying genetic and environmental factors. Lifestyle practices such…”
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Beyond race: Recruitment of diverse participants in clinical genomics research for rare disease by Young, Jennifer L., Halley, Meghan C., Anguiano, Beatriz, Fernandez, Liliana, Bernstein, Jonathan A., Wheeler, Matthew T., Tabor, Holly K.

“…Purpose: Despite recent attention to increasing diversity in clinical genomics research, researchers still struggle to recruit participants from varied…”
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Defining genotype-phenotype relationships in patients with hypertrophic cardiomyopathy using cardiovascular magnetic resonance imaging by Miller, Robert J H, Heidary, Shahriar, Pavlovic, Aleksandra, Schlachter, Audrey, Dash, Rajesh, Fleischmann, Dominik, Ashley, Euan A, Wheeler, Matthew T, Yang, Phillip C

“…HCM is the most common inherited cardiomyopathy. Historically, there has been poor correlation between genotype and phenotype. However, CMR has the potential…”
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Knowledge and attitudes on implementing cardiovascular pharmacogenomic testing by Russell, Callan, Campion, MaryAnn, Grove, Megan E., Matsuda, Kelly, Klein, Teri E., Ashley, Euan, Naik, Hetanshi, Wheeler, Matthew T., Scott, Stuart A.

“…Pharmacogenomics has the potential to inform drug dosing and selection, reduce adverse events, and improve medication efficacy; however, provider knowledge of…”
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Generation of two induced pluripotent stem cell lines carrying the phospholamban R14del mutation for modeling ARVD/C by Vera, Carlos D., Manhas, Amit, Shenoy, Sushma P., Wheeler, Matthew T., Sallam, Karim, Wu, Joseph C.

“…The phospholamban (PLN) R14del mutation is associated with arrhythmogenic right ventricular dysplasia (ARVD/C). ARVD/C is a cardiac disease characterized by…”
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Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients by Zushin, Peter-James H., Zhou, Yang, Li, Audrey, Ashley, Euan A., Wheeler, Matthew T., Wu, Joseph C.

“…Dilated cardiomyopathies (DCM) are one of the main causes of heart failure as one ages. BAG3 is a chaperone protein that is heavily implicated in the…”
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Phased whole-genome genetic risk in a family quartet using a major allele reference sequence by Dewey, Frederick E, Chen, Rong, Cordero, Sergio P, Ormond, Kelly E, Caleshu, Colleen, Karczewski, Konrad J, Whirl-Carrillo, Michelle, Wheeler, Matthew T, Dudley, Joel T, Byrnes, Jake K, Cornejo, Omar E, Knowles, Joshua W, Woon, Mark, Sangkuhl, Katrin, Gong, Li, Thorn, Caroline F, Hebert, Joan M, Capriotti, Emidio, David, Sean P, Pavlovic, Aleksandra, West, Anne, Thakuria, Joseph V, Ball, Madeleine P, Zaranek, Alexander W, Rehm, Heidi L, Church, George M, West, John S, Bustamante, Carlos D, Snyder, Michael, Altman, Russ B, Klein, Teri E, Butte, Atul J, Ashley, Euan A

“…Whole-genome sequencing harbors unprecedented potential for characterization of individual and family genetic variation. Here, we develop a novel synthetic…”
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Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying TTN mutations by Zhang, Tina Tianbo, Zhao, Shane Rui, Alamana, Christina, Shen, Mengcheng, Parikh, Victoria, Wheeler, Matthew T., Wu, Joseph C.

“…Dilated cardiomyopathy (DCM) is a common heart disease that can lead to heart failure and sudden cardiac death. Mutations in the TTN gene are the most frequent…”
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Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation by Beijer, Danique, Kim, Hong Joo, Guo, Lin, O'Donovan, Kevin, Mademan, Inès, Deconinck, Tine, Van Schil, Kristof, Fare, Charlotte M, Drake, Lauren E, Ford, Alice F, Kochański, Andrzej, Kabzińska, Dagmara, Dubuisson, Nicolas, Van den Bergh, Peter, Voermans, Nicol C, Lemmers, Richard Jlf, van der Maarel, Silvère M, Bonner, Devon, Sampson, Jacinda B, Wheeler, Matthew T, Mehrabyan, Anahit, Palmer, Steven, De Jonghe, Peter, Shorter, James, Taylor, J Paul, Baets, Jonathan

“…Mutations in HNRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare cause of amyotrophic lateral sclerosis (ALS) and multisystem…”
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Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying TNNI3 mutations by Zhao, Shane Rui, Shen, Mengcheng, Lee, Chelsea, Zha, Yanjun, Guevara, Julio V., Wheeler, Matthew T., Wu, Joseph C.

“…•Mutations in TNNI3 gene result in hypertrophic cardiomyopathy (HCM).•We generated three human-induced pluripotent stem cell (iPSC) lines from HCM patients…”
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