Search Results - "Wheeler, Linda"

Initiation of genome instability and preneoplastic processes through loss of Fhit expression by Saldivar, Joshua C, Miuma, Satoshi, Bene, Jessica, Hosseini, Seyed Ali, Shibata, Hidetaka, Sun, Jin, Wheeler, Linda J, Mathews, Christopher K, Huebner, Kay

“…Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile…”
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Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells by Mannava, Sudha, Grachtchouk, Vladimir, Wheeler, Linda J., Im, Michael, Zhuang, Dazhong, Slavina, Elena G., Mathews, Christopher K., Shewach, Donna S., Nikiforov, Mikhail A.

“…To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via…”
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Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Natarajan, Venkatesh, Zucker, Shoshanna N, Fink, Emily E, Im, Michael, Flanagan, Sheryl, Burhans, William C, Zeitouni, Nathalie C, Shewach, Donna S, Mathews, Christopher K, Nikiforov, Mikhail A

“…In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have…”
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Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools by Koç, Ahmet, Wheeler, Linda J., Mathews, Christopher K., Merrill, Gary F.

“…The relationship between dNTP levels and DNA synthesis was investigated using α factor-synchronized yeast treated with the ribonucleotide reductase inhibitor…”
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Nucleoside Triphosphate Pool Asymmetry in Mammalian Mitochondria by Wheeler, Linda J., Mathews, Christopher K.

“…Our laboratory has reported that deoxyribonucleoside triphosphate (dNTP) pools in rat tissue mitochondria are highly asymmetric, with dGTP predominating, and…”
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Ribonucleotide Reductase Association with Mammalian Liver Mitochondria by Chimploy, Korakod, Song, Shiwei, Wheeler, Linda J., Mathews, Christopher K.

“…Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes to the elevated mutation rate…”
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p53 Mediates Senescence-Like Arrest Induced by Chronic Replicational Stress by Marusyk, Andriy, Wheeler, Linda J., Mathews, Christopher K., DeGregori, James

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effects of a Mitochondrial Mutator Mutation in Yeast POS5 NADH Kinase on Mitochondrial Nucleotides by Wheeler, Linda J., Mathews, Christopher K.

“…Saccharomyces cerevisiae contains three NADH/NAD+ kinases, one of which is localized in mitochondria and phosphorylates NADH in preference to NAD+. Strand et…”
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Thioredoxin Is Required for Deoxyribonucleotide Pool Maintenance during S Phase by Koc, Ahmet, Mathews, Christopher K., Wheeler, Linda J., Gross, Michael K., Merrill, Gary F.

“…Thioredoxin was initially identified by its ability to serve as an electron donor for ribonucleotide reductase in vitro. Whether it serves a similar function…”
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Deoxyribonucleotide Pool Imbalance Stimulates Deletions in HeLa Cell Mitochondrial DNA by Song, Shiwei, Wheeler, Linda J., Mathews, Christopher K.

“…Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with multiple mutations in mitochondrial DNA, both…”
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Stimulation of mutagenesis by proportional deoxyribonucleoside triphosphate accumulation in Escherichia coli by Wheeler, Linda J., Rajagopal, Indira, Mathews, Christopher K.

“…Intracellular pool sizes of deoxyribonucleoside triphosphates (dNTPs) are highly regulated. Unbalanced dNTP pools, created by abnormal accumulation or…”
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Measuring DNA precursor pools in mitochondria by Mathews, Christopher K, Wheeler, Linda J

“…The ability to measure molar concentrations of deoxyribonucleoside 5'-triphosphates (dNTPs) within the mitochondrial matrix is important for several reasons…”
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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion by Mannava, Sudha, Moparthy, Kalyana C, Wheeler, Linda J, Leonova, Katerina I, Wawrzyniak, Joseph A, Bianchi-Smiraglia, Anna, Berman, Albert E, Flanagan, Sheryl, Shewach, Donna S, Zeitouni, Nathalie C, Gudkov, Andrei V, Mathews, Christopher K, Nikiforov, Mikhail A

“…The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely…”
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Fission Yeast Iec1-Ino80-Mediated Nucleosome Eviction Regulates Nucleotide and Phosphate Metabolism by Hogan, Cassandra Justine, Aligianni, Sofia, Durand-Dubief, Mickaël, Persson, Jenna, Will, William R, Webster, Judith, Wheeler, Linda, Mathews, Christopher K, Elderkin, Sarah, Oxley, David, Ekwall, Karl, Varga-Weisz, Patrick Daniel

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Retinoblastoma Tumor Suppressor Targets dNTP Metabolism to Regulate DNA Replication by Angus, Steven P, Wheeler, Linda J, Ranmal, Sejal A, Zhang, Xiaoping, Markey, Michael P, Mathews, Christopher K, Knudsen, Erik S

“…The retinoblastoma tumor suppressor, RB, is a negative regulator of the cell cycle that is inactivated in the majority of human tumors. Cell cycle inhibition…”
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The influence of concept mapping on critical thinking in baccalaureate nursing students by Wheeler, Linda A, Collins, Susan K.R

“…This article describes a quasi-experimental study that used a pretest-posttest design with a control group to evaluate the effectiveness of concept mapping in…”
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Molecular interactions involving Escherichia coli nucleoside diphosphate kinase by Shen, Rongkun, Wheeler, Linda J, Mathews, Christopher K

“…Nucleoside diphosphate kinase plays a distinctive metabolic role as the enzyme poised between the last reaction of deoxyribonucleoside triphosphate (dNTP)…”
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Involvement of deoxycytidylate deaminase in the response to S(n)1-type methylation DNA damage in budding yeast by Liskay, R Michael, Wheeler, Linda J, Mathews, Christopher K, Erdeniz, Naz

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Pre‐replication assembly of E. coli replisome components by Den Blaauwen, Tanneke, Aarsman, Mirjam E. G., Wheeler, Linda J., Nanninga, Nanne

“…Summary The localization of SeqA, thymidylate synthase, DnaB (helicase) and the DNA polymerase components α and τ, has been studied by immunofluorescence…”
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Replication-independent MCB gene induction and deoxyribonucleotide accumulation at G1/S in Saccharomyces cerevisiae by Koç, Ahmet, Wheeler, Linda J, Mathews, Christopher K, Merrill, Gary F

“…In Saccharomyces cerevisiae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferentially near the G1/S boundary of the…”
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