Search Results - "Wheeler, Leroy W."

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine by MCDOLE, Jeremiah R, WHEELER, Leroy W, MCDONALD, Keely G, BAOMEI WANG, KONJUFCA, Vjollca, KNOOP, Kathryn A, NEWBERRY, Rodney D, MILLER, Mark J

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Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies by Lu, Yingjuan J, Chu, Haiyan, Wheeler, Leroy W, Nelson, Melissa, Westrick, Elaine, Matthaei, James F, Cardle, Ian I, Johnson, Adam, Gustafson, Joshua, Parker, Nikki, Vetzel, Marilynn, Xu, Le-Cun, Wang, Emilia Z, Jensen, Michael C, Klein, Patrick J, Low, Philip S, Leamon, Christopher P

“…Chimeric antigen receptor (CAR)-T cell therapy has transformed pediatric oncology by producing high remission rates and potent effects in CD19+ B-cell…”
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Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes by Lu, Yingjuan J., Wheeler, Leroy W., Chu, Haiyan, Kleindl, Paul J., Pugh, Michael, You, Fei, Rao, Satish, Garcia, Gabriela, Wu, Henry Y., da Cunha, Andre P., Johnson, Richard, Westrick, Elaine, Cross, Vicky, Lloyd, Alex, Dircksen, Christina, Klein, Patrick J., Vlahov, Iontcho R., Low, Philip S., Leamon, Christopher P.

“…Provoked by sterile/nonsterile insults, prolonged monocyte mobilization and uncontrolled monocyte/macrophage activation can pose imminent or impending harm to…”
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Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine by McDole, Jeremiah R., Wheeler, Leroy W., McDonald, Keely G., Wang, Baomei, Konjufca, Vjollca, Knoop, Kathryn A., Newberry, Rodney D., Miller, Mark J.

“…Goblet cells in the small intestine act as passages delivering small antigens to tolerance-inducing dendritic cells in the lamina propria. Striking an…”
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Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells by Wheeler, Leroy W., Lents, Nathan H., Baldassare, Joseph J.

“…Progression through the mammalian cell division cycle is regulated by the sequential activation of cyclin-dependent kinases, CDKs, at specific phases of the…”
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Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents Adriamycin and Actinomycin D by Lents, Nathan H, Wheeler, Leroy W, Baldassare, Joseph J, Dynlacht, Brian David

“…Mdm2, as the most important negative regulator of p53, plays an important homeostatic role in regulating cell division and the cellular response to DNA damage,…”
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CCR6 promotes steady‐state mononuclear phagocyte association with the intestinal epithelium, imprinting and immune surveillance by McDonald, Keely G., Wheeler, Leroy W., McDole, Jeremiah R., Joerger, Shannon, Gustafsson, Jenny K., Kulkarni, Devesha H., Knoop, Kathryn A., Williams, Ifor R., Miller, Mark J., Newberry, Rodney D.

“…Summary The intestinal lamina propria (LP) contains antigen‐presenting cells with features of dendritic cells and macrophages, collectively referred to as…”
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Abstract 262: Combination therapy of folate-targeted chemotherapeutics with anti-PD-1 antibody against folate receptor-positive tumors in immunocompetent murine models by Lu, Yingjuan June, Wheeler, Leroy W., Cross, Vicky, Westrick, Elaine, Lloyd, Alex, Leamon, Christopher P.

“…Abstract The PD-1/PD-L1 (programmed cell death protein 1; programmed death-ligand 1) pathway plays a key role in immunological tolerance and autoimmunity. PD-1…”
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Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumenal Retinoids by McDonald, Keely G, Leach, Matthew R, Brooke, Kaitlin W.M, Wang, Caihong, Wheeler, Leroy W, Hanly, Elyse K, Rowley, Christopher W, Levin, Marc S, Wagner, Michael, Li, Ellen, Newberry, Rodney D

“…Dendritic cells (DCs) use all-trans retinoic acid (ATRA) to promote characteristic intestinal responses, including Foxp3+ Treg conversion, lymphocyte gut…”
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Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development by Wang, Caihong, Hanly, Elyse K., Wheeler, Leroy W., Kaur, Manreet, McDonald, Keely G., Newberry, Rodney D.

“…Background: Blockade of the integrin α4β7 has promise as a therapy for inflammatory bowel disease. α4β7 plays diverse roles in the intestinal immune system,…”
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Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis by Lu, Yingjuan, Wollak, Kristin N, Cross, Vicky A, Westrick, Elaine, Wheeler, Leroy W, Stinnette, Torian W, Vaughn, Jeremy F, Hahn, Spencer J, Xu, Le-Cun, Vlahov, Iontcho R, Leamon, Christopher P

“…Abstract EC0746 is a rationally designed anti-inflammatory drug conjugate consisting of a modified folic acid-based ligand linked to a γ-hydrazide analog of…”
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22 Goblet Cells Deliver Luminal Retinoids and Imprint CD103+ Lamina Propria Dendritic Cells by McDonald, Keely G, Wheeler, Leroy W, Knoop, Kathryn, Miller, Miller J, Newberry, Rodney D

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588 Distinct Dendritic Cell Subtypes with Dichotomous Phenotypes Are Associated with the Murine Small Intestinal Epithelium by Wheeler, Leroy W, Kaur, Manreet, McDonald, Keely, Newberry, Rodney D

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Abstract 4574: Combinatorial strategies of folate receptor-targeted chemotherapy guided by improved understanding of tumor microenvironment and immunomodulation by Lu, Yingjuan, Wheeler, Leroy W., Cross, Vicky A., Westrick, Elaine M., Lloyd, Alex M., Johnson, Theresa P., Parker, Nikki L., Leamon, Christopher P.

“…Abstract Inflammation disorder is a major component of cancer progression and drug resistance. Tumor microenvironment due to its complex nature presents…”
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Abstract 3670: Treatment of epithelial ovarian cancer with folate receptor (α/β) targeted chemotherapy is enhanced by CTLA-4 blockade: Learning from animal models by Lu, Yingjuan, Johnson, Theresa P., Wheeler, Leroy W., Lloyd, Alex M., Cross, Vicky A., Westrick, Elaine M., Parker, Nikki L., Leamon, Christopher P.

“…Abstract Epithelial ovarian cancer (EOC) remains to be the most lethal form of gynecologic malignancies despite aggressive cytoreductive surgery (i.e…”
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Abstract LB-109: Adaptor controlled CAR-T cell immunotherapy for treatment of folate receptor-alpha/beta positive solid and liquid tumors by Lu, Yingjuan June, Chu, Haiyan, Wheeler, Leroy W., Nelson, Mellissa, Westrick, Elaine M., Vetzel, Marilynn R., Klein, Patrick J., Johnson, Adam J., Yokoyama, Jason K., Gustafson, Joshua A., Jensen, Michael C., Lee, Yong-Gu, Low, Philip S., Leamon, Christopher P.

“…Abstract Personalized immunotherapy has reached a pivotal milestone with the recent approval of CD19-directed chimeric antigen receptor (CAR) T-cell therapies…”
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CCR6 promotes steady-state mononuclear phagocyte associationￂ with the intestinal epithelium, imprinting and immune surveillance by McDonald, Keely G, Wheeler, Leroy W, McDole, Jeremiah R, Joerger, Shannon, Gustafsson, Jenny K, Kulkarni, Devesha H, Knoop, Kathryn A, Williams, Ifor R, Miller, Mark J, Newberry, Rodney D

“…Summary The intestinal lamina propria (LP) contains antigen-presenting cells with features of dendritic cells and macrophages, collectively referred to as…”
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Abstract 4495: Small molecule approach for targeting tumor-associated macrophages via a functional FRβ by Wheeler, Leroy W., Lu, Yingjuan, Cross, Vicky, Lloyd, Alex, Parker, Nikki, Qi, Longwu, Wang, Kevin, Wang, Ian, Hahn, Spencer, Vaughn, Jeremy, Vlahov, Iontcho P., Low, Philip S., Leamon, Christopher P.

“…Abstract Tumor-associated macrophages (TAMs) are considered an attractive target for oncotherapy because of their important role in tumor microenvironment…”
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Goblet cells deliver luminal antigen to CD103.sup.+ dendritic cells in the small intestine by McDole, Jeremiah R, Wheeler, Leroy W, McDonald, Keely G, Wang, Baomei, Konjufca, Vjollca, Knoop, Kathryn A, Newberry, Rodney D

“…Goblet cells in the small intestine act as passages delivering small antigens to tolerance-inducing dendritic cells in the lamina propria…”
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Goblet cells deliver luminal antigen to [CD103.sup.+] dendritic cells in the small intestine by McDole, Jeremiah R, Wheeler, Leroy W, McDonald, Keely G, Wang, Baomei, Konjufca, Vjollca, Knoop, Kathryn A, Newberry, Rodney D, Miller, Mark J

“…The intestinal immune system is exposed to a mixture of foreign antigens from diet, commensal flora and potential pathogens. Understanding how…”
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