Search Results - "Wheeler, Kenneth T"

Radiation-induced brain injury: A review by Greene-Schloesser, Dana, Robbins, Mike E, Peiffer, Ann M, Shaw, Edward G, Wheeler, Kenneth T, Chan, Michael D

“…Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (>6 months) to experience radiation-induced brain injury…”
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Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site by Xu, Jinbin, Zeng, Chenbo, Chu, Wenhua, Pan, Fenghui, Rothfuss, Justin M., Zhang, Fanjie, Tu, Zhude, Zhou, Dong, Zeng, Dexing, Vangveravong, Suwanna, Johnston, Fabian, Spitzer, Dirk, Chang, Katherine C., Hotchkiss, Richard S., Hawkins, William G., Wheeler, Kenneth T., Mach, Robert H.

“…The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel…”
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Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1 by Shoghi, Kooresh I, Xu, Jinbin, Su, Yi, He, June, Rowland, Douglas, Yan, Ying, Garbow, Joel R, Tu, Zhude, Jones, Lynne A, Higashikubo, Ryuji, Wheeler, Kenneth T, Lubet, Ronald A, Mach, Robert H, You, Ming

“…The sigma-2 receptor is expressed in higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells, thus providing an attractive target for…”
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The AT1 Receptor Antagonist, L-158,809, Prevents or Ameliorates Fractionated Whole-Brain Irradiation–Induced Cognitive Impairment by Robbins, Mike E., Ph.D, Payne, Valerie, B.S, Tommasi, Ellen, B.S, Diz, Debra I., Ph.D, Hsu, Fang-Chi, Ph.D, Brown, William R., Ph.D, Wheeler, Kenneth T., Ph.D, Olson, John, M.S, Zhao, Weiling, Ph.D

“…Purpose We hypothesized that administration of the angiotensin type 1 (AT1) receptor antagonist, L-158,809, to young adult male rats would prevent or…”
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Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: A potential rat model of vascular dementia by Brown, William R, Blair, Robert M, Moody, Dixon M, Thore, Clara R, Ahmed, Stephanie, Robbins, Michael E, Wheeler, Kenneth T

“…Abstract Brain tumor patients who are long-term survivors after whole-brain irradiation (WBI) often suffer cognitive impairment, including dementia. Although…”
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Vascular Damage after Fractionated Whole-Brain Irradiation in Rats by Brown, William R., Thore, Clara R., Moody, Dixon M., Robbins, Michael E., Wheeler, Kenneth T.

“…Brown, W. R., Thore, C. R., Moody, D. M., Robbins, M. E. and Wheeler, K. T. Vascular Damage after Fractionated Whole-Brain Irradiation in Rats. Radiat. Res…”
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Hippocampal Neuron Number Is Unchanged 1 Year After Fractionated Whole-Brain Irradiation at Middle Age by Shi, Lei, M.D., Ph.D, Molina, Doris P., B.A, Robbins, Michael E., Ph.D, Wheeler, Kenneth T., Ph.D, Brunso-Bechtold, Judy K., Ph.D

“…Purpose To determine whether hippocampal neurons are lost 12 months after middle-aged rats received a fractionated course of whole-brain irradiation (WBI) that…”
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Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairment by Shi, Lei, Linville, M. Constance, Iversen, Elizabeth, Molina, Doris P, Yester, Jessie, Wheeler, Kenneth T, Robbins, Michael E, Brunso-Bechtold, Judy K

“…Abstract Radiation therapy is used widely to treat primary and metastatic brain tumors, but also can lead to delayed neurological complications. Since…”
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A Gated-7T MRI Technique for Tracking Lung Tumor Development and Progression in Mice after Exposure to Low Doses of Ionizing Radiation by Olson, John D., Walb, Matthew C., Moore, Joseph E., Attia, Albert, Sawyer, Heather L., McBride, Jennifer E., Wheeler, Kenneth T., Miller, Mark Steven, Munley, Michael T.

“…A gated-7T magnetic resonance imaging (MRI) application is described that can accurately and efficiently measure the size of in vivo mouse lung tumors from…”
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PET Radiotracers for Imaging the Proliferative Status of Solid Tumors by Mach, Robert H., PhD, Dehdashti, Farrokh, MD, Wheeler, Kenneth T., PhD

“…Two different strategies have been developed for imaging the proliferative status of solid tumors with the functional imaging technique, PET. The first…”
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Subcellular localization of Sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy by CHENBO ZENG, VANGVERAVONG, Suwanna, JINBIN XU, CHANG, Katherine C, HOTCHKISS, Richard S, WHEELER, Kenneth T, DUANWEN SHEN, ZHUANG, Zhi-Ping, KUNG, Hank F, MACH, Robert H

“…Sigma-2 receptor agonists have been shown to induce cell death via caspase-dependent and caspase-independent pathways. Unfortunately, there is little…”
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Fluorine-18-Labeled Benzamide Analogues for Imaging the σ2 Receptor Status of Solid Tumors with Positron Emission Tomography by Tu, Zhude, Xu, Jinbin, Jones, Lynne A, Li, Shihong, Dumstorff, Craig, Vangveravong, Suwanna, Chen, Delphine L, Wheeler, Kenneth T, Welch, Michael J, Mach, Robert H

“…A series of fluorine-containing benzamide analogs was synthesized and evaluated as candidate ligands for positron emission tomography (PET) imaging of the…”
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Pathology of Fractionated Whole-Brain Irradiation in Rhesus Monkeys (Macaca mulatta) by Hanbury, David B., Robbins, Mike E., Bourland, J. Daniel, Wheeler, Kenneth T., Peiffer, Ann M., Mitchell, Erin L., Daunais, James B., Deadwyler, Samuel A., Cline, J. Mark

“…Fractionated whole-brain irradiation (fWBI), used to treat brain metastases, often leads to neurologic injury and cognitive impairment. The cognitive effects…”
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Differential Expression of Homer1a in the Hippocampus and Cortex Likely Plays a Role in Radiation-Induced Brain Injury by Moore, Elizabeth D., Kooshki, Mitra, Wheeler, Kenneth T., Metheny-Barlow, Linda J., Robbins, Mike E.

“…Fractionated partial or whole-brain irradiation is the primary treatment for metastatic brain tumors. Despite reducing tumor burden and increasing lifespan,…”
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A Model for Assessing Cognitive Impairment after Fractionated Whole-Brain Irradiation in Nonhuman Primates by Robbins, Mike E, Bourland, J. Daniel, Cline, J. Mark, Wheeler, Kenneth T, Deadwyler, Sam A

“…To investigate the effect of fractionated whole-brain irradiation on nonhuman primates, 6–9-year-old male rhesus monkeys were irradiated with 40 Gy delivered…”
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Aging masks detection of radiation-induced brain injury by Shi, Lei, Olson, John, D'Agostino, Ralph, Linville, Constance, Nicolle, Michelle M, Robbins, Michael E, Wheeler, Kenneth T, Brunso-Bechtold, Judy K

“…Abstract Fractionated partial or whole-brain irradiation (fWBI) is a widely used, effective treatment for primary and metastatic brain tumors, but it also…”
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New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ2 receptor ligands : Synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents by WENHUA CHU, JINBIN XU, DONG ZHOU, FANJIE ZHANG, JONES, Lynne A, WHEELER, Kenneth T, MACH, Robert H

“…A series of N -substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs were synthesized. Among them, WC-26 and WC-59 were identified as the most…”
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Cellular response of the rat brain to single doses of (137)Cs γ rays does not predict its response to prolonged 'biologically equivalent' fractionated doses by Greene-Schloesser, Dana M, Kooshki, Mitra, Payne, Valerie, D'Agostino, Jr, Ralph B, Wheeler, Kenneth T, Metheny-Barlow, Linda J, Robbins, Mike E

“…To determine if the brain's response to single doses predicts its response to 'biologically equivalent' fractionated doses. Young adult male Fischer 344 rats…”
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Total-body irradiation produces late degenerative joint damage in rats by Hutchinson, Ian D., Olson, John, Lindburg, Carl A., Payne, Valerie, Collins, Boyce, Smith, Thomas L., Munley, Michael T., Wheeler, Kenneth T., Willey, Jeffrey S.

“…Abstract Purpose: Premature musculoskeletal joint failure is a major source of morbidity among childhood cancer survivors. Radiation effects on synovial joint…”
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Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo by Mach, Robert Henry, Wheeler, Kenneth Theodore

“…The sigma-2 (sigma(2)) receptor is proving to be an important protein in the field of cancer biology. The observations that sigma(2) receptors have a 10-fold…”
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