Search Results - "Wheeler, Jun X."
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Quantitation of thrombin-activatable fibrinolysis inhibitor in human plasma by isotope dilution mass spectrometry
Published in Analytical biochemistry (01-02-2022)“…Measurement of Thrombin-activatable fibrinolysis inhibitor (TAFI) in human plasma is dependent on reproducible assays. To date, standards for measuring TAFI…”
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Measurement of surface protein antigens, PorA and PorB, in Bexsero vaccine using quantitative mass spectrometry
Published in Vaccine (05-02-2020)“…Bexsero is a multivalent vaccine containing outer membrane vesicles (OMV) derived from Neisseria meningitidis group B strain NZ98/254 and three recombinant…”
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Corrected and Republished from: "A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge"
Published in Infection and immunity (25-01-2022)“…Current vaccination against Streptococcus pneumoniae uses vaccines based on capsular polysaccharides from selected serotypes and has led to nonvaccine serotype…”
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A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge
Published in Infection and immunity (01-03-2019)“…Current vaccination against uses vaccines based on capsular polysaccharides from selected serotypes and has led to nonvaccine serotype replacement disease. We…”
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Quantification of Müllerian Inhibiting Substance/Anti-Müllerian Hormone polypeptide by isotope dilution mass spectrometry
Published in Analytical biochemistry (01-11-2018)“…Measurement of serum concentrations of Müllerian inhibiting substance (MIS), also known as anti-Müllerian Hormone (AMH) by immunoassay is gaining clinical…”
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Correction for Chan et al., "A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge"
Published in Infection and immunity (25-01-2022)Get full text
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The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies
Published in The Journal of biological chemistry (20-12-2019)“…Therapeutic mAbs are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the…”
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Proteomic Analysis Reveals Temporal Changes in Protein Expression in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes In Vitro
Published in Stem cells and development (01-05-2019)“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) hold great promise for regenerative medicine and in vitro screening. Despite displaying…”
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Mass spectrometry analysis reveals differences in the host cell protein species found in pseudotyped lentiviral vectors
Published in Biologicals (01-03-2018)“…Lentiviral vectors (LVs) have been successfully used in clinical trials showing long term therapeutic benefits. Studying the role of cellular proteins in…”
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Dissection of the function of the RmpM periplasmic protein from Neisseria meningitidis
Published in Microbiology (Society for General Microbiology) (01-02-2016)“…RmpM is a periplasmic protein from Neisseria meningitidis that comprises an N-terminal domain (residues 1-47) and a separate globular C-terminal domain…”
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Immunogenicity profiling of protein antigens from capsular group B Neisseria meningitidis
Published in Scientific reports (02-05-2019)“…Outer membrane vesicle (OMV)- based vaccines have been used to provide strain-specific protection against capsular group B Neisseria meningitidis infections,…”
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In vitro and in vivo growth alter the population dynamic and properties of a Jeryl Lynn mumps vaccine
Published in Vaccine (26-08-2015)“…Highlights • Mumps vaccines contain live attenuated viruses that are manufactured in cell substrates. • The production of the JL-CK vaccine in primary canine…”
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Characterization of the key antigenic components and pre-clinical immune responses to a meningococcal disease vaccine based on Neisseria lactamica outer membrane vesicles
Published in Human vaccines (01-01-2008)“…Serogroup B strains are now responsible for over 80% of meningococcal disease in the UK and no suitable vaccine is available that confers universal protection…”
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Characterisation of the Protein Content of a Meningococcal Outer Membrane Vesicle Vaccine by Polyacrylamide Gel Electrophoresis and Mass Spectrometry
Published in Human vaccines (01-03-2005)“…The development and evaluation of outer membrane vesicles as vaccines against meningococcal disease has been carried out for more than two decades. Although…”
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Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis
Published in Journal of proteomics (14-04-2014)“…Meningococcal surface proteins capable of evoking a protective immune response are candidates for inclusion in protein-based vaccines against serogroup B…”
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Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14 (H5N1)
Published in Vaccine (02-12-2008)“…Abstract The assessment of potential candidate influenza vaccine viruses includes a number of factors. Growth properties of the virus and yield of antigen,…”
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Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254
Published in Proteomics (Weinheim) (01-06-2006)“…In the absence of a suitable carbohydrate‐based vaccine, outer membrane vesicle (OMV) vaccines have been used to disrupt outbreaks of serogroup B meningococcal…”
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Factor H binding protein (fHbp)-mediated differential complement resistance of a serogroup C Neisseria meningitidis isolate from cerebrospinal fluid of a patient with invasive meningococcal disease
Published in Access microbiology (23-09-2021)“…During an outbreak of invasive meningococcal disease (IMD) at the University of Southampton, UK, in 1997, two Neisseria meningitidis serogroup C isolates were…”
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Identification of peptide sequences as a measure of Anthrax vaccine stability during storage
Published in Human vaccines & immunotherapeutics (2014)“…The UK anthrax vaccine is an alum precipitate of a sterile filtrate of Bacillus anthracis Sterne culture (AVP). An increase in shelf life of AVP from 3 to 5…”
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Bioanalysis of meningococcal vaccines
Published in Bioanalysis (01-02-2010)“…Meningococcal meningitis is feared because of the rapid onset of severe disease from mild symptoms and, therefore, is an important target for vaccine research…”
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