Search Results - "Wheeler, Joshua"

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure by Jain, Saumya, Wheeler, Joshua R., Walters, Robert W., Agrawal, Anurag, Barsic, Anthony, Parker, Roy

“…Stress granules are mRNA-protein granules that form when translation initiation is limited, and they are related to pathological granules in various…”
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The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules by Khong, Anthony, Matheny, Tyler, Jain, Saumya, Mitchell, Sarah F., Wheeler, Joshua R., Parker, Roy

“…Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some…”
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Distinct stages in stress granule assembly and disassembly by Wheeler, Joshua R, Matheny, Tyler, Jain, Saumya, Abrisch, Robert, Parker, Roy

“…Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with…”
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Isolation of yeast and mammalian stress granule cores by Wheeler, Joshua R., Jain, Saumya, Khong, Anthony, Parker, Roy

“…•Stress granule cores are stable ex vivo.•Stress granule cores contain known stress granule components and RNA.•Stress granule cores are purified using a…”
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TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle by Vogler, Thomas O., Wheeler, Joshua R., Nguyen, Eric D., Hughes, Michael P., Britson, Kyla A., Lester, Evan, Rao, Bhalchandra, Betta, Nicole Dalla, Whitney, Oscar N., Ewachiw, Theodore E., Gomes, Edward, Shorter, James, Lloyd, Thomas E., Eisenberg, David S., Taylor, J. Paul, Johnson, Aaron M., Olwin, Bradley B., Parker, Roy

“…A dominant histopathological feature in neuromuscular diseases, including amyotrophic lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation…”
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Trajectory-Based Time-Resolved Mechanism for Benzene Reductive Elimination from Cyclopentadienyl Mo/W Phenyl Hydride Complexes by Wheeler, Joshua I., Schaefer, Anthony J., Ess, Daniel H.

“…Calculated potential energy structures and landscapes are very often used to define the sequence of reaction steps in an organometallic reaction mechanism and…”
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A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells by Braselmann, Esther, Wierzba, Aleksandra J., Polaski, Jacob T., Chromiński, Mikołaj, Holmes, Zachariah E., Hung, Sheng-Ting, Batan, Dilara, Wheeler, Joshua R, Parker, Roy, Jimenez, Ralph, Gryko, Dorota, Batey, Robert T., Palmer, Amy E.

“…RNAs directly regulate a vast array of cellular processes, emphasizing the need for robust approaches to fluorescently label and track RNAs in living cells…”
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Isolation of mammalian stress granule cores for RNA-Seq analysis by Khong, Anthony, Jain, Saumya, Matheny, Tyler, Wheeler, Joshua R., Parker, Roy

“…•SG cores can be biochemically purified by successive centrifugation and immunoprecipitation.•Validation of RNA-Seq results by single molecule FISH.•Image…”
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Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch by Mishra, Santosh K., Wheeler, Joshua J., Pitake, Saumitra, Ding, Huiping, Jiang, Changyu, Fukuyama, Tomoki, Paps, Judy S., Ralph, Patrick, Coyne, Jacob, Parkington, Michelle, DeBrecht, Jennifer, Ehrhardt-Humbert, Lauren C., Cruse, Glenn P., Bäumer, Wolfgang, Ji, Ru-Rong, Ko, Mei-Chuan, Olivry, Thierry

“…Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that…”
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The Donnan-dominated resting state of skeletal muscle fibers contributes to resilience and longevity in dystrophic fibers by Morris, Catherine E, Wheeler, Joshua J, Joos, Béla

“…Duchenne muscular dystrophy (DMD) is an X-linked dystrophin-minus muscle-wasting disease. Ion homeostasis in skeletal muscle fibers underperforms as DMD…”
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TDP43 ribonucleoprotein granules: physiologic function to pathologic aggregates by Corbet, Giulia Ada, Wheeler, Joshua R., Parker, Roy, Weskamp, Kaitlin

“…Ribonucleoprotein (RNP) assemblies are ubiquitous in eukaryotic cells and have functions throughout RNA transcription, splicing, and stability. Of the…”
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Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase by Bakooshli, Mohsen A, Wang, Yu Xin, Monti, Elena, Su, Shiqi, Kraft, Peggy, Nalbandian, Minas, Alexandrova, Ludmila, Wheeler, Joshua R, Vogel, Hannes, Blau, Helen M

“…To date, there are no approved treatments for the diminished strength and paralysis that result from the loss of peripheral nerve function due to trauma,…”
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The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae by Bhalla, Manmeet, Herring, Sydney, Lenhard, Alexsandra, Wheeler, Joshua R, Aswad, Fred, Klumpp, Klaus, Rebo, Justin, Wang, Yan, Wilhelmsen, Kevin, Fortney, Kristen, Bou Ghanem, Elsa N

“…(pneumococcus) remains a serious cause of pulmonary and systemic infections globally, and host-directed therapies are lacking. The aim of this study was to…”
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Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state by Daniel, Bence, Belk, Julia A., Meier, Stefanie L., Chen, Andy Y., Sandor, Katalin, Czimmerer, Zsolt, Varga, Zsofia, Bene, Krisztian, Buquicchio, Frank A., Qi, Yanyan, Kitano, Hugo, Wheeler, Joshua R., Foster, Deshka S., Januszyk, Michael, Longaker, Michael T., Chang, Howard Y., Satpathy, Ansuman T.

“…Cell cycle (CC) facilitates cell division via robust, cyclical gene expression. Protective immunity requires the expansion of pathogen-responsive cell types,…”
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Computational determination of coordination structure impact on adsorption and acidity of pristine and sulfated MOF-808 by Yang, Bo, Wheeler, Joshua I, Sorensen, Brett, Steagall, Robert, Nielson, Taylor, Yao, Jianhua, Mendez-Arroyo, Jose, Ess, Daniel H

“…Metal-organic frameworks (MOFs) are composed of metal nodes connected by organic linkers. With the massive amount of possible metal and linker combinations, it…”
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Itch-associated Neuropeptides and Their Receptor Expression in Dog Dorsal Root Ganglia and Spinal Cord by Wheeler, Joshua J, Lascelles, B Duncan, Olivry, Thierry, Mishra, Santosh K

“…Most canine visits to veterinarians are related to skin diseases with itch being the chief complaint. Historically, several itch-inducing molecules and…”
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Cognitive interviewing as a method to inform questionnaire design and validity - Immersive Technology Evaluation Measure (ITEM) for healthcare education by Jacobs, Chris, Wheeler, Joshua, Williams, Michael, Joiner, Richard

“…Research of immersive technology in education is rapidly expanding with potential to educate future students in healthcare disciplines. Despite increasing…”
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The regenerating skeletal muscle niche drives satellite cell return to quiescence by Cutler, Alicia A., Pawlikowski, Bradley, Wheeler, Joshua R., Dalla Betta, Nicole, Elston, Tiffany, O’Rourke, Rebecca, Jones, Kenneth, Olwin, Bradley B.

“…Skeletal muscle stem cells, or satellite cells (SCs), are essential to regenerate and maintain muscle. Quiescent SCs reside in an asymmetric niche between the…”
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Correlation of Artemin and GFRα3 With Osteoarthritis Pain: Early Evidence From Naturally Occurring Osteoarthritis-Associated Chronic Pain in Dogs by Minnema, Laura, Wheeler, Joshua, Enomoto, Masataka, Pitake, Saumitra, Mishra, Santosh K, Lascelles, B Duncan X

“…Arthritis, including osteoarthritis (OA) and other musculoskeletal-associated pain, is a worldwide problem, however, effective drug options are limited…”
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RNA-binding proteins direct myogenic cell fate decisions by Wheeler, Joshua R, Whitney, Oscar N, Vogler, Thomas O, Nguyen, Eric D, Pawlikowski, Bradley, Lester, Evan, Cutler, Alicia, Elston, Tiffany, Dalla Betta, Nicole, Parker, Kevin R, Yost, Kathryn E, Vogel, Hannes, Rando, Thomas A, Chang, Howard Y, Johnson, Aaron M, Parker, Roy, Olwin, Bradley B

“…RNA-binding proteins (RBPs), essential for skeletal muscle regeneration, cause muscle degeneration and neuromuscular disease when mutated. Why mutations in…”
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