Search Results - "Wheeler, Allison P."

2021 clinical trials update: Innovations in hemophilia therapy by Croteau, Stacy E., Wang, Michael, Wheeler, Allison P.

“…Therapies engineered to prolong clotting factor protein circulation time, manipulate the balance of pro‐coagulant and anti‐coagulant proteins, or introduce new…”
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Why factor XI deficiency is a clinical concern by Wheeler, Allison P, Gailani, David

“…Inherited fXI deficiency has been an enigma since its discovery in 1953. The variable and relatively mild symptoms in patients with even the most severe form…”
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The Intrinsic Pathway of Coagulation as a Target for Antithrombotic Therapy by Wheeler, Allison P., MD, MSCI, Gailani, David, MD

“…Plasma coagulation in the activated partial thromboplastin time assay is initiated by sequential activation of coagulation factors XII, XI, and IX. While this…”
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Thrombosis risk with haemoglobin C trait and haemoglobin C disease: A systematic review by Jacobs, Jeremy W, Sharma, Deva, Stephens, Laura D, Figueroa Villalba, Cristina A, Rinder, Henry M, Woo, Jennifer S, Wheeler, Allison P, Gerberi, Dana, Goel, Ruchika, Tormey, Christopher A, Booth, Garrett S, Bloch, Evan M, Adkins, Brian D

“…The thrombotic risk with haemoglobin C trait (HbAC) or haemoglobin C disease (HbCC) is unclear. However, individuals with HbCC have demonstrated chronic…”
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Use of a real-time risk-prediction model to identify pediatric patients at risk for thromboembolic events: study protocol for the Children’s Likelihood Of Thrombosis (CLOT) trial by Walker, Shannon C, French, Benjamin, Moore, Ryan, Domenico, Henry J, Wanderer, Jonathan P, Balla, Sreenivasa, Creech, C. Buddy, Byrne, Daniel W, Wheeler, Allison P

“…Abstract Background Pediatric patients have increasing rates of hospital-associated venous thromboembolism (HA-VTE), and while several risk-prediction models…”
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Coagulation factor inhibitors in COVID‐19: From SARS‐CoV‐2 vaccination to infection by Jacobs, Jeremy W., Adkins, Brian D., Walker, Shannon C., Booth, Garrett S., Wheeler, Allison P.

“…Recent reports have highlighted patients with COVID‐19 and vaccine recipients diagnosed with coagulation factor inhibitors. This is challenging. as severe…”
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Pharmacokinetic‐tailored approach to hemophilia prophylaxis: Medical decision making and outcomes by Croteau, Stacy E., Wheeler, Allison P., Khan, Osman, Haley, Kristina M., Borst, Alexandra J., Lattimore, Susan, Yeung, Cindy H.T., Iorio, Alfonso

“…Clinical application of population pharmacokinetics (popPK) is of increasing interest to patients with hemophilia, providers, and payers. Routine use of popPK…”
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A high-throughput liquid bead array assay confirms strong correlation between SARS-CoV-2 antibody level and COVID-19 severity by Bennett, Monique, Yoder, Sandra, Brady, Eric, Pulley, Jill M., Rhoads, Jillian P., Stewart, Thomas G., Bernard, Gordon R., Creech, C. Buddy, Wheeler, Allison P., Thomsen, Isaac

“…A detailed understanding of the adaptive host response to SARS-CoV-2 infection in humans is urgently needed. We developed a sensitive, high-throughput, and…”
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US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021 by See, Isaac, Su, John R, Lale, Allison, Woo, Emily Jane, Guh, Alice Y, Shimabukuro, Tom T, Streiff, Michael B, Rao, Agam K, Wheeler, Allison P, Beavers, Suzanne F, Durbin, Anna P, Edwards, Kathryn, Miller, Elaine, Harrington, Theresa A, Mba-Jonas, Adamma, Nair, Narayan, Nguyen, Duong T, Talaat, Kawsar R, Urrutia, Victor C, Walker, Shannon C, Creech, C. Buddy, Clark, Thomas A, DeStefano, Frank, Broder, Karen R

“…IMPORTANCE: Cerebral venous sinus thrombosis (CVST) with thrombocytopenia, a rare and serious condition, has been described in Europe following receipt of the…”
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Standardized two-step testing of antibody activity in COVID-19 convalescent plasma by Gilchuk, Pavlo, Thomsen, Isaac, Yoder, Sandra, Brady, Eric, Chappell, James D., Stevens, Laura J., Denison, Mark R., Sutton, Rachel E., Chen, Rita E., VanBlargan, Laura A., Suryadevara, Naveenchandra, Zost, Seth J., Schmitz, Jonathan, Pulley, Jill M., Diamond, Michael S., Rhoads, Jillian P., Bernard, Gordon R., Self, Wesley H., Rice, Todd W., Wheeler, Allison P., Crowe, James E., Carnahan, Robert H.

“…The COVID-19 pandemic revealed an urgent need for rapid profiling of neutralizing antibody responses and development of antibody therapeutics. The current Food…”
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Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results by Shapiro, Amy D., Angchaisuksiri, Pantep, Astermark, Jan, Benson, Gary, Castaman, Giancarlo, Chowdary, Pratima, Eichler, Hermann, Jiménez-Yuste, Victor, Kavakli, Kaan, Matsushita, Tadashi, Poulsen, Lone Hvitfeldt, Wheeler, Allison P., Young, Guy, Zupancic-Salek, Silva, Oldenburg, Johannes

“…Results from the main parts (24 weeks) of 2 concizumab phase 2 trials are presented: explorer4 in hemophilia A (HA) or B (HB) with inhibitors (HAwI/HBwI) and…”
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Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination-United States, December 2020 to August 2021 by See, Isaac, Lale, Allison, Marquez, Paige, Streiff, Michael B, Wheeler, Allison P, Tepper, Naomi K, Woo, Emily Jane, Broder, Karen R, Edwards, Kathryn M, Gallego, Ruth, Geller, Andrew I, Jackson, Kelly A, Sharma, Shashi, Talaat, Kawsar R, Walter, Emmanuel B, Akpan, Imo J, Ortel, Thomas L, Urrutia, Victor C, Walker, Shannon C, Yui, Jennifer C, Shimabukuro, Tom T, Mba-Jonas, Adamma, Su, John R, Shay, David K

“…Thrombosis with thrombocytopenia syndrome (TTS) is a potentially life-threatening condition associated with adenoviral-vectored COVID-19 vaccination. It…”
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Severe muscle bleeds in children and young adults with hemophilia A on emicizumab prophylaxis: Real-world retrospective multi-institutional cohort by Batsuli, Glaivy, Wheeler, Allison P, Weyand, Angela C, Sidonio, Jr, Robert F, Young, Guy

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A Real-time Risk-Prediction Model for Pediatric Venous Thromboembolic Events by Walker, Shannon C, Creech, C Buddy, Domenico, Henry J, French, Benjamin, Byrne, Daniel W, Wheeler, Allison P

“…Hospital-associated venous thromboembolism (HA-VTE) is an increasing cause of morbidity in pediatric populations, yet identification of high-risk patients…”
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Diversity, equity, and inclusion in transfusion medicine, blood donation, and blood and bone marrow transplantation: language matters by Jacobs, Jeremy W., Adkins, Brian D., Wheeler, Allison P., Booth, Garrett S.

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Representation of Authors by Gender, Race, and Ethnicity in Pathology Clinical Practice Guidelines by Martin, Amarilis A, Walker, Shannon C, Wheeler, Allison P, Jacobs, Jeremy W, Booth, Garrett S, Silver, Julie K

“…United States' clinical practice guidelines (CPGs) are often produced by professional societies and used worldwide in daily medical practice. However, studies…”
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Assessment of the CLOT (children's likelihood of thrombosis) real-time risk prediction model of hospital-associated venous thromboembolism in children with congenital heart disease by Sunthankar, Sudeep D., Moore, Ryan P., Byrne, Daniel W., Domenico, Henry J., Wheeler, Allison P., Walker, Shannon C., Kannankeril, Prince J.

“…Children with congenital heart disease (CHD) are at high risk for hospital-associated venous thromboembolism (HA-VTE). The children's likelihood of thrombosis…”
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Trends in dedicated care for females with bleeding disorders within U.S. hemophilia treatment centers by Wheeler, Allison P., Lim, Ming Y., Huguelet, Patricia S., Jaffray, Julie, Staber, Janice M., Funkhouser, Kerry, Carpenter, Shannon L., Weyand, Angela C.

“…Graphical representation of increasing percentage of female patients seen at HTCs, percentage of females by diagnosis, number of clinics in existence, and…”
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Chromogenic and Clot-Based Bivalirudin Assays for Monitoring Anticoagulation by Raghavendran, Prashant, Tillman, Benjamin F, Wheeler, Allison P, Gailani, David

“…Abstract Background Direct thrombin inhibitors (DTIs) are usually monitored with the activated partial thromboplastin time (aPTT) or activated clotting time…”
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Regional variation and cost implications of prescribed extended half‐life factor concentrates among U.S. Haemophilia Treatment Centres for patients with moderate and severe haemophilia by Croteau, Stacy E., Cheng, Dunlei, Cohen, Alice J., Holmes, Chris E., Malec, Lynn M., Silvey, Michael, Thornburg, Courtney D., Wheeler, Allison P., Kouides, Peter A., Raffini, Leslie J., Neufeld, Ellis J.

“…Background Extended half‐life (EHL) factor VIII (FVIII) and IX (FIX) products are intended to decrease the burden of prophylaxis for patients with haemophilia…”
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