Search Results - "Wheeldon, E B"

Housing and welfare in laboratory rats: time-budgeting and pathophysiology in single-sex groups by HURST, J.L., BARNARD, C.J., HARE, R., WHEELDON, E.B., WEST, C.D.

“…Alderley Park (Wistar-derived) rats, Rattus norvegicus, were maintained in single-sex groups of eight for 9 weeks under open-room conditions. Both sexes could…”
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Image analysis of bromodeoxyuridine (BrdU) staining for measurement of S-phase in rat and mouse liver by Soames, AR, Lavender, D, Foster, JR, Williams, SM, Wheeldon, EB

“…We developed a system for quantifying the numbers of bromodeoxyuridine (BrdU)-labeled hepatocyte nuclei in rat and mouse liver with an automated image analysis…”
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Quantitation of apoptotic bodies in rat liver by in situ end labelling (ISEL): correlation with morphology by Wheeldon, E B, Williams, S M, Soames, A R, James, N H, Roberts, R A

“…Nongenotoxic hepatocarcinogens have been proposed to inhibit hepatocyte apoptosis, preventing the removal of DNA-damaged cells. Conclusive proof of this…”
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Intratracheal aerosolization of endotoxin in the rat: a model of the adult respiratory distress syndrome (ARDS) by Wheeldon, E.B, Walker, M.E, Murphy, D.J, Turner, C.R

“…A technique is described for the intratracheal aerosolization of endotoxin into the rat. Using a miniaturized nozzle within the tracheal lumen to optimize…”
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Dosing-Induced Stress Causes Hepatocyte Apoptosis in Rats Primed by the Rodent Nongenotoxic Hepatocarcinogen Cyproterone Acetate by Roberts, R.A., Soames, A.R., James, N.H., Gill, J.H., Wheeldon, E.B.

“…It has been proposed that several nongenotorric compounds act as hepatocarcinogens by suppressing the apoptosis that would normally act to remove damaged or…”
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Intravascular macrophages in the sheep lung by Wheeldon, E B, Hansen-Flaschen, J H

“…The presence of a resident population of intravascular macrophages in the sheep lung was investigated. Injection of fluorescent microspheres into the sheep…”
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Toxicogenomics in Predictive Toxicology in Drug Development by Suter, Laura, Babiss, Lee E, Wheeldon, Eric B

“…The goal of toxicology is the assessment of possible risk to man. An emerging technology with the potential to have a major impact on risk assessment is…”
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Leukotriene D4 (LTD4) induces mucus secretion from goblet cells in the guinea pig respiratory epithelium by Hoffstein, S T, Malo, P E, Bugelski, P, Wheeldon, E B

“…To study the potential role of leukotriene (LTD4) as a mucus secretagogue, anesthetized and spontaneously breathing guinea pigs were intubated and challenged…”
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Pulmonary toxicologic pathology: perspective and symposium highlights by Schwartz, L W, Harkema, J R, Haschek-Hock, W M, Lomax, L G, Wheeldon, E B

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The effect of human recombinant tissue-type plasminogen activator on clinical and laboratory parameters of hemostasis and systemic plasminogen activation in the dog and the rat by Bloom, J C, Sellers, T S, Gries, G C, Wheeldon, E B, O'Brien, S R, Lewis, H B

“…The effect of human recombinant tissue-type plasminogen activator (rt-PA) on parameters of hemostasis and systemic plasminogen activation was studied in the…”
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Goat papillomatosis by Theilen, G, Wheeldon, E B, East, N, Madewell, B, Lancaster, W D, Munn, R

“…The present study indicates that the development of caprine mammary gland warts seems to depend on several factors--namely, nonpigmented skin, adult age,…”
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Intestinal adenomatosis in a foal by Duhamel, G E, Wheeldon, E B

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First report of Trichinella spiralis var. pseudospiralis in North America by Wheeldon, E.B, Dick, T.A, Schulz, T.A

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Therapeutic intervention in a rat model of ARDS: IV. Phosphodiesterase IV inhibition by Turner, C R, Esser, K M, Wheeldon, E B

“…The following study was performed to determine the effects of phosphodiesterase IV (PDE-IV) inhibition and its attenuation of tumor necrosis factor (TNF alpha)…”
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Reduced disease in aged rats treated chronically with ibopamine, a catecholaminergic drug by Walker, R F, Weideman, C A, Wheeldon, E B

“…As part of preclinical safety testing for carcinogenicity, postpubertal (50 days old) rats were dosed (0, 30, 90 or 180 mg/kg/day) with ibopamine…”
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Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response by Smith, J G, Raper, S E, Wheeldon, E B, Hackney, D, Judy, K, Wilson, J M, Eck, S L

“…Replication-defective adenovirus expressing the herpes simplex thymidine kinase gene (H5.010RSVtk) may be useful in treating human gliomas. To determine the…”
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Neoplasia of the larynx in the dog by Wheeldon, E B, Suter, P F, Jenkins, T

“…The clinical, radiographic, gross pathologic, and histologic findings in 4 dogs with primary laryngeal neoplasia and 1 dog with secondary laryngeal neoplasia…”
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Laryngeal carcinoma in a cat by Wheeldon, E B, Amis, T C

“…Laryngeal neoplasia was diagnosed in a 5-year-old domestic shorthair cat examined for cough and gagging episodes. Resection of the mass revealed a squamous…”
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Epornitic of avian pox in a raptor rehabilitation center by Wheeldon, E B, Sedgwick, C J, Schulz, T A

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Microwave fixation of the lung by Turner, C R, Zuczek, S, Knudsen, D J, Wheeldon, E B

“…A technique for microwave fixation of inflated rat lung is described. Conventional intratracheal fixation with instillation of fixative into the airways at a…”
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