Search Results - "Wheadon, H"

Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL by Middleton, O, Cosimo, E, Dobbin, E, McCaig, A M, Clarke, C, Brant, A M, Leach, M T, Michie, A M, Wheadon, H

“…Monoclonal antibodies (MAbs) form a central part of chronic lymphocytic leukaemia (CLL) treatment. We therefore evaluated whether complement defects in CLL…”
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Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways by Dobbin, E, Graham, C, Freeburn, R W, Unwin, R D, Griffiths, J R, Pierce, A, Whetton, A D, Wheadon, H

“…Objective proteomic analysis offers opportunities for hypothesis generation on molecular events associated with pathogenesis in stem cells. Relative…”
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Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells by Dobbin, E, Corrigan, P.M, Walsh, C.P, Welham, M.J, Freeburn, R.W, Wheadon, H

“…Abstract The leukemic oncogene Tel/PDGFRβ, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during…”
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Tissue specificity of X-chromosome inactivation patterns by GALE, R. E, WHEADON, H, BOULOS, P, LINCH, D. C

“…The analysis of X-chromosome inactivation patterns has been used in a number of clinical situations such as the identification of carrier status in X-linked…”
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Regulation of Embryonic Stem Cell Self-renewal by Phosphoinositide 3-Kinase-dependent Signaling by Paling, Nicholas R D, Wheadon, Helen, Bone, Heather K, Welham, Melanie J

“…The maintenance of murine embryonic stem (ES) cell self-renewal is regulated by leukemia inhibitory factor (LIF)-dependent activation of signal transducer and…”
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PF466 POTENTIAL COMBINATIONAL THERAPY OF LEUKEMIC STEM CELLS USING BONE MORPHOGENETIC PROTEIN AND TYROSINE KINASE INHIBITORS by Busch, C., Wheadon, H., Copland, M., Berry, C.

“…Background: Chronic myeloid leukemia (CML) disease outcomes have improved since the introduction of tyrosine kinase inhibitors (TKIs), however a proportion of…”
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Frequency of clonal remission in acute myeloid leukaemia by Gale, R E, Wheadon, H, Goldstone, A H, Burnett, A K, Linch, D C

“…Analysis of X-chromosome inactivation patterns in females has been used to assess clonality of various tumours and for prenatal diagnosis of X-linked…”
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Tel/PDGFRbeta inhibits self-renewal and directs myelomonocytic differentiation of ES cells by Dobbin, E, Corrigan, P M, Walsh, C P, Welham, M J, Freeburn, R W, Wheadon, H

“…The leukemic oncogene Tel/PDGFRbeta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during…”
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The coupling of TEL/PDGFβR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases by Wheadon, Helen, Welham, Melanie J.

“…The TEL/PDGFβR oncogenic fusion protein is the product of the t(5;12)(q33; p13) translocation recurrently found in patients with chronic myelomonocytic…”
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Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2) by Wheadon, Helen, Edmead, Christine, Welham, Melanie J

“…The cytosolic SHP-2 (Src homology protein tyrosine phosphatase 2) has previously been implicated in IL-3 (interleukin-3) signalling [Bone, Dechert, Jirik,…”
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Molecular interactions of SHP1 and SHP2 in IL-3-signalling by Wheadon, Helen, Paling, Nicholas R.D., Welham, Melanie J.

“…SHP1 and SHP2 tyrosine phosphatases have both been implicated in signalling pathways downstream of the interleukin-3 (IL-3) receptor. We have investigated the…”
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X-chromosome inactivation patterns using HPRT and PGK polymorphisms in haematologically normal and post-chemotherapy females by Gale, R E, Wheadon, H, Linch, D C

“…Clonal analysis using X-chromosome inactivation patterns of the hypoxanthine phosphoribosyl transferase (HPRT) and phosphoglycerate kinase (PGK) genes has been…”
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Assessment of X-chromosome inactivation patterns using the hypervariable probe M27 beta in normal hemopoietic cells and acute myeloid leukemic blasts by Gale, R E, Wheadon, H, Linch, D C

“…The value of the hypervariable X-linked probe M27 beta for use in the analysis of X-chromosome inactivation patterns in normal blood and bone marrow cells and…”
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Changes in signal transduction downstream from the granulocyte-macrophage colony-stimulating factor receptor during differentiation of primary hemopoietic cells by Wheadon, Helen, Roberts, Pamela J, Watts, Michael J, Linch, David C

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifuctional cytokine, having different effects on primitive hemopoietic cells and terminally…”
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Differentiation‐linked changes in granulocyte‐macrophage colony‐stimulating factor receptor mediated signalling in the HL‐60 promyelocytic cell line by Wheadon, Helen, Roberts, Pamela J., Linch, David C.

“…Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) induces the proliferation and maturation of immature myeloid progenitor cells and primes mature cell…”
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Granulocyte‐macrophage colony stimulating factor receptor α and β chain complexes can form both high and intermediate affinity functional receptors by WHEADON, HELEN, DEVEREUX, STEPHEN, KHWAJA, ASIM, LINCH, DAVID C.

“…Scatchard analysis of primary human haemopoietic cells using iodinated GM‐CSF suggests that there are low, intermediate and high affinity classes of the GM‐CSF…”
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"It's Safer By Sea" by WHEADON, H

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