Search Results - "Whawell, Simon"

MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1 by Hunt, Stuart, Jones, Adam V., Hinsley, Emma E., Whawell, Simon A., Lambert, Daniel W.

“…Alterations in the levels of molecules which interact with the extracellular matrix, such as integrins, are associated with invasion of oral squamous cell…”
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Physiological Fluid Flow Moderates Fibroblast Responses to TGF‐β1 by Nithiananthan, Sadhvi, Crawford, Aileen, Knock, Johnathan Cooper, Lambert, Daniel W., Whawell, Simon A.

“…ABSTRACT Fibroblasts are the major cellular component of connective tissue and experience mechanical perturbations due to matrix remodelling and interstitial…”
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The chemokine lymphotactin and its recombinant variants in oral cancer cell regulation by Abdullah Zubir, Amir Zaki, Whawell, Simon A., Wong, Tuck Seng, Khurram, Syed Ali

“…Background The expression of XCR1 receptor and its metamorphic ligand lymphotactin (hLtn) has been shown in cancers but their precise role in tumorigenesis is…”
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ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with αvβ6 integrin by Jones, Adam V., Lambert, Daniel W., Speight, Paul M., Whawell, Simon A.

“…•ADAM 10 is increased in OSCC compared to normal oral mucosa and dysplasia.•Oral cancer cell lines show increased ADAM 10 expression compared to normal…”
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Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal-epithelial interactions by Hinsley, Emma E., Hunt, Stuart, Hunter, Keith D., Whawell, Simon A., Lambert, Daniel W.

“…The invasion and migration of cancer cells is increasingly recognised to be influenced by factors derived from adjacent tumour‐associated stroma. The…”
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Oral cancer stem cells drive tumourigenesis through activation of stromal fibroblasts by Al‐Magsoosi, Mohanad J. N., Lambert, Daniel W., Ali Khurram, Syed, Whawell, Simon A.

“…Background Cancer stem cells are responsible for tumour progression and chemoresistance. Fibroblasts surrounding a tumour also promote progression and…”
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The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour by Khurram, Syed A., Bingle, Lynne, McCabe, Brenka M., Farthing, Paula M., Whawell, Simon A.

“…Background Chemokines regulate physiological and pathological leucocyte trafficking, and chemokine receptors play a role in tumorigenesis. Expression of…”
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The Periodontal Pathogen Porphyromonas gingivalis Preferentially Interacts with Oral Epithelial Cells in S Phase of the Cell Cycle by Al-Taweel, Firas B, Douglas, C W Ian, Whawell, Simon A

“…Porphyromonas gingivalis, a key periodontal pathogen, is capable of invading a variety of cells, including oral keratinocytes, by exploiting host cell…”
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Differential adhesion and invasion by Staphylococcus aureus of epithelial cells derived from different anatomical sites by RIDLEY, Robert A, DOUGLAS, Ian, WHAWELL, Simon A

“…Staphylococcus aureus can invade epithelial cells, and the host-cell receptor α(5)β(1) integrin is thought to mediate this process. The aim of this study was…”
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Identification of key determinants in Porphyromonas gingivalis host‐cell invasion assays by Al‐Taweel, Firas B. H., Al‐Magsoosi, Mohanad J. N., Douglas, Charles W. I., Whawell, Simon A.

“…The periodontal pathogen Porphyromonas gingivalis can invade host cells, a virulence trait which may contribute to the persistence of infection at subgingival…”
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Temporal mismatch between pain behaviour, skin Nerve Growth factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain by Evans, Laura J, Loescher, Alison R, Boissonade, Fiona M, Whawell, Simon A, Robinson, Peter P, Andrew, David

“…The neurotrophin Nerve Growth factor (NGF) is known to influence the phenotype of mature nociceptors, for example by altering synthesis of neuropeptides, and…”
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Internalization of Staphylococcus aureus by Human Keratinocytes by KINTARAK, Sompid, WHAWELL, Simon A, SPEIGHT, Paul M, PACKER, Samantha, NAIR, Sean P

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Functional expression of the chemokine receptor XCR1 on oral epithelial cells by Khurram, Syed A, Whawell, Simon A, Bingle, Lynne, Murdoch, Craig, McCabe, Brenka M, Farthing, Paula M

“…Chemokines are chemoattractant cytokines which act on specific receptors and play an important role in leukocyte migration as well as physiological and…”
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αE(CD103)β7 integrin interacts with oral and skin keratinocytes in an E-cadherin-independent manner by Jenkinson, Sarah E, Whawell, Simon A, Swales, Brenka M, Corps, Elaine M, Kilshaw, Peter J, Farthing, Paula M

“…The integrin αE(CD103)β7 (αEβ7) is expressed by intraepithelial lymphocytes, dendritic cells and regulatory T cells. It plays an important role in the mucosal…”
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The alpha E(CD103) beta 7 integrin interacts with oral and skin keratinocytes in an E-cadherin-independent manner by Jenkinson, Sarah E, Whawell, Simon A, Swales, Brenka M, Corps, Elaine M, Kilshaw, Peter J, Farthing, Paula M

“…The integrin alpha E(CD103) beta 7 ( alpha E beta 7) is expressed by intraepithelial lymphocytes, dendritic cells and regulatory T cells. It plays an important…”
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Expression of the αvβ6 Integrin Promotes Migration and Invasion in Squamous Carcinoma Cells by Thomas, Gareth J., Lewis, Mark P., Whawell, Simon A., Russell, Alan, Sheppard, Dean, Hart, Ian R., Speight, Paul M., Marshall, John F.

“…The integrin αvβ6 is a fibronectin receptor whose expression is not detectable on normal oral epithelium but is increased significantly in healing and in oral…”
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The role of α9β1 integrin in modulating epithelial cell behaviour by Roy, Sushmita, Bingle, Lynne, Marshall, John F., Bass, Rosemary, Ellis, Vincent, Speight, Paul M., Whawell, Simon A.

“…J Oral Pathol Med (2011) 40: 755–761 Background:  Integrins initiate signalling in response to the extracellular matrix (ECM), which is important in wound…”
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Functional Regulation of Tissue Plasminogen Activator on the Surface of Vascular Smooth Muscle Cells by the Type-II Transmembrane Protein p63 (CKAP4) by Razzaq, Tahir M., Bass, Rosemary, Vines, David J., Werner, Finn, Whawell, Simon A., Ellis, Vincent

“…We have demonstrated that tissue plasminogen activator (tPA) binds specifically to human vascular smooth muscle cells (VSMC) in a functionally relevant manner,…”
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Force generation and protease gene expression in organotypic co-cultures of fibroblasts and keratinocytes by Wall†, Ivan B., Bhadal†, Navneet, Broad, Simon, Whawell, Simon A., Mudera, Vivek, Lewis, Mark P.

“…Fibroblast–epithelium interactions are crucial for successful tissue engineering of skin and oral mucosal equivalents. In this study, we assessed early force…”
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Modulation of the urokinase-type plasminogen activator receptor by the β6 integrin subunit by Dalvi, Nafisa, Thomas, Gareth J, Marshall, John F, Morgan, Mark, Bass, Rosemary, Ellis, Vincent, Speight, Paul M, Whawell, Simon A

“…Over-expression of components of the urokinase system is well documented in cancer and is thought to enable tumour cells to migrate and invade. Changes in…”
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